Protein Alignment dao and Smyd4-3

DIOPT Version :10

• Sequence 1: NP_609742.1
• Gene: dao / 34891
• FlyBaseID: FBgn0028862
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_725048.1
• Gene: Smyd4-3 / 36234
• FlyBaseID: FBgn0033633
• Length: 660
• Species: Drosophila melanogaster
• Alignment Length: 664
• Identity: 143/664 - (21%)
• Similarity: 254/664 - (38%)
• Gaps: 163/664 - (24%)

  Fly   161 KSEEESRRLREAGNDSYRKERHPLKASDLFTEAIFLAPARNTLAAALAHANRSLVLFDCGLYAES 225
            |:...:..::|....:::.::. |:|..|:|.:....|:.|.....:..||||..|:    :.:.
  Fly    69 KNASLAAEIKERATSAFKAKKW-LEAMMLYTRSYVALPSENVAEIRVVLANRSATLY----HMQK 128

  Fly   226 YDDCLC----ALDLGYPEEYLPLIKLRQAACALKLR-------NFALC---------------EE 264
            |.:||.    ||||.|.::.:..:..|||.|.:.|:       :|..|               :.
  Fly   129 YQECLIDIKRALDLSYSKDLIYKLYERQARCYMALKDYPHTIDSFKKCITAMDDSTLASDKRAKL 193

  Fly   265 HLHELLHIELNQVFEARTHELWHQCEVLKVERFEMAVQTGDDLDINDSKAFEIAWLD-NSSSLHT 328
            :|..:..|::.| .:.||.:     :..|.::.::|:.....:.:.:.....:..:| |......
  Fly   194 NLDAMTMIKMLQ-NDPRTAK-----QEAKQQKQKIALDQAKPVKLENEFVSPLVRIDSNRQEGRF 252

  Fly   329 TRAVAK----NALIFESEAVAMVPSGNCRV-CDYCGITQFIPFPCIYCSNRLVVYCSRQCRFKHA 388
            .||.|.    ..|:.|...|:::.....:. |:.|.:...:|..|..|::  |:|||.|||.:.:
  Fly   253 ARASADVKPGEELLVERPFVSVLLEKFAKTHCENCFMRTVVPVACPRCAD--VLYCSEQCREEAS 315

  Fly   389 -AIHAVECFGHQIELFESFGEVFGMPRLLQLAFRMLITGLPELLGHCRKKPT--LSKLWSAINGG 450
             ..|..|| |....::.|...:..     .:|.|::.:           ||.  ..||...|:..
  Fly   316 KKYHKYEC-GIVPIIWRSGASINN-----HIALRIIAS-----------KPLDYFLKLKPTIDEE 363

  Fly   451 LQERQDIA-----YSAVLRLERLKEERPTDTVIALALAAHILSIYLSKCTT---FFDQLEKSLPT 507
            |...|.|:     :..|.:|||.:.||.........|.|.    :|:.|..   :|
  Fly   364 LTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQHVLMAR----FLTNCLRAGGYF--------- 415

  Fly   508 ASRMSSAEWELLCAALLMRHIGQLRHRSLTACRSFVLPADPHVFSPLNEFQLWAAPMRLQEGHLH 572
            .|.....|..::|:.:|         |||.     .:..:.|..:.|::|.        ..|.
  Fly   416 GSEPKPDEVSIICSLVL---------RSLQ-----FIQFNTHEVAELHKFS--------SSGR-- 456

  Fly   573 LLAGEVAV-VSYSVYPDTLNLCRHSCSSTICAKFSGRTVTALALLDLPAGSGIYNCFAGGNFQQL 636
                |.:: :..::|| ||.|..|||...:...|.|.|:...::..:.||..|...: |..:.|.
  Fly   457 ----EKSIFIGGAIYP-TLALFNHSCDPGVVRYFRGTTIHINSVRPIEAGLPINENY-GPMYTQD 515

  Fly   637 PREERTKQLLE-SGIRCHCNACQLTHSDDQFHKFH-------RYRCDNP-NCMEIFTPNALPHAP 692
            .|.||..:|.: ....|.|:||     .|.:.||.       |:|||.| ||      :|:...|
  Fly   516 ERSERQARLKDLYWFECSCDAC-----IDNWPKFDDLPRDVIRFRCDAPNNC------SAVIEVP 569

  Fly   693 SLRWWLSEEYTQPEFNGADLIMCPHCGEYQKLEWFWAFTTSLIDCELIEERCKLYAAIERAENQL 757
                        |..|.. ::.|..|||         .|..|...:::::.    ..:.|...:|
  Fly   570 ------------PSCNDF-MVKCVTCGE---------ITNILKGLKVMQDT----EMMTRTAKRL 608

  Fly   758 MDLHECKVALARLL 771
            .:..|...|||:.:
  Fly   609 YETGEYPKALAKFV 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dao	NP_609742.1	TPR repeat	200..235	CDD:276809	11/38 (29%)
		TPR repeat	243..270	CDD:276809	8/48 (17%)
		SET	<459..657	CDD:394802	45/202 (22%)
Smyd4-3	NP_725048.1	TPR repeat	74..103	CDD:276809	5/29 (17%)
		TPR repeat	108..142	CDD:276809	11/37 (30%)
		TPR repeat	150..177	CDD:276809	6/26 (23%)
		SET_SMYD4	235..537	CDD:380934	80/363 (22%)
		zf-MYND	284..323	CDD:460312	13/40 (33%)