Protein Alignment dao and Smyd4-1

DIOPT Version :10

• Sequence 1: NP_609742.1
• Gene: dao / 34891
• FlyBaseID: FBgn0028862
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_610500.2
• Gene: Smyd4-1 / 35985
• FlyBaseID: FBgn0033427
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 747
• Identity: 233/747 - (31%)
• Similarity: 353/747 - (47%)
• Gaps: 62/747 - (8%)

  Fly   142 FRPHVLKWFQHLRHQTGHFKSEEESRRLREAGNDSYRK------ERHPLKASDLFTEAIFLAPAR 200
            |:...|...|.|..........|.|:.|||.||..:::      :...|||..|::||:|  .|.
  Fly    42 FQKLALDLLQDLEQPVDRKGCAERSKNLREEGNLMFKESASGSSKDSVLKACRLYSEAVF--EAE 104

  Fly   201 NTL-AAALAHANRSLVLFDCGLYAESYDDCLCALDLGYPEEYLPLIKLRQAACALKLRNFALCEE 264
            |.: ..:||.|||.:.|.:.|.|.|:||||..||:.||||.....:.:|||.||.||:..|..||
  Fly   105 NAVEELSLAFANRGIALQEYGYYREAYDDCSNALECGYPERLRHKVIMRQAFCAWKLKKIASLEE 169

  Fly   265 HLHELLHIELNQVFEARTHELWHQCEVLKVERFEMAVQ-------TGDDL-DINDSKAFEIAWLD 321
            ||..|..::|.:.||.:..:|..:.|:||.:..|...|       .|:.| |......:.:|
  Fly   170 HLDYLGQLQLKESFEQQLEDLKQKLELLKNQPREQETQGKVVDKSLGEILTDPGPRGRYMVA--- 231

  Fly   322 NSSSLHTTRAVAKNALIFESEAVAMVPSGNCRVCDYCGIT-QFIPFPCIYCSNRLVVYCSRQCRF 385
                   ..|::|..:||...|...||.....:|..|..| ...|.||..|..| ||||||:||.
  Fly   232 -------KEAISKGNVIFSERASCFVPLEQLLICQQCAATLMSAPIPCPNCHQR-VVYCSRKCRE 288

  Fly   386 KHAAIHAVECFGHQIELFESFGEVFGMPRLLQLAFRMLITGLPELLGHCRKKPTLSKLWSAINGG 450
            .|:|||..||..::.::....|       :..||.|:|:|.:|.:..|.::..:...:|..|. .
  Fly   289 AHSAIHKFECAAYRKDILRLLG-------ISHLALRLLLTYIPYIRPHLQEMTSAKGMWEEIM-N 345

  Fly   451 LQERQDIAYSAVLRLERLKEERPTDTVIALALAAHI-----LSIYLSKCTTFFDQLEKSLPTASR 510
            |..:.:.:.:|...|..|:.....|..|...|..||     |.:||.:.|.|:||.. |||.
  Fly   346 LSRKPEESENAPEYLRSLRMVSQLDQAIDEELNYHILCANLLQLYLKEHTDFYDQFH-SLPA--- 406

  Fly   511 MSSAEWELLCAALLMRHIGQLRHRSLTACRSFVLPADPHVFSPLNEFQLWAAPMRLQEGHLHLLA 575
             |..:|:|:.:||::|..|||............:..:|..|..|.. :||..|..|:.|.||.|:
  Fly   407 -SIEDWQLIISALILRFAGQLLANGHVGDALLGVGMEPKEFVMLQP-ELWQKPRHLKRGQLHNLS 469

  Fly   576 GEVAVVSYSVYPDTLNLCRHSCSSTICAKFSGRTVTALALLDLPAGSGIYNCFAGG--NFQQLPR 638
            ....:.:.::  ..|:||.|:|..:|..||.|.:|...|..|:..|..|:||:...  |..:|.|
  Fly   470 HSDPITAINL--PYLSLCNHACEPSIRTKFDGCSVVNYAAKDILEGEEIFNCYTMDYRNSLKLQR 532

  Fly   639 EERTKQLLESGIRCHCNACQLTHSDDQFHKFHRYRCDNPNCMEIFTPNALPHAPSLRWWLSEEYT 703
            ....|.:.:  ..|.|..|..|..|..:..||||||:.|||.:.|.|:|.....:|||||.....
  Fly   533 SHPLKAIYK--FECTCAKCTRTDPDQNYLSFHRYRCEKPNCRQEFLPDAKVQQNNLRWWLRCNAE 595

  Fly   704 QPEFNGADLIMCPHCGEYQKLEWFWAFTTSLIDCELIEERCKLYAAIERAENQLMDLHECKVALA 768
            :|       |.|..|.|.|...|:..|...:.......:|..|:.|.:..:..|:|.|..|..:|
  Fly   596 KP-------ITCTVCHELQHFAWYNEFLGLIGSSADSSKRQALFKAFDDLDKWLVDHHSLKRIMA 653

  Fly   769 RLLLEQCLMVHREGATVLDDWEFNKLGSILRSVLPSVMAQYGGQSIEYVKYFSYFWDVMALSNYK 833
            ..|:..| ....:|.|.||::|:..|..|:|..|..:.||.|..|.||:...:|.||::|....:
  Fly   654 EELVTAC-FYEIDGGTSLDEFEYEDLARIIRKQLEGIAAQCGDNSTEYIARMTYLWDIIAQKKCR 717

  Fly   834 CNDRELMQMLNALEFIADEFKDIFINYYEDYI 865
            .:.:||::|...::::|.|.:::|:|||.|:|
  Fly   718 TDRKELLEMKGKVDYLASEHREVFLNYYNDFI 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dao	NP_609742.1	TPR repeat	200..235	CDD:276809	16/35 (46%)
		TPR repeat	243..270	CDD:276809	12/26 (46%)
		SET	<459..657	CDD:394802	60/204 (29%)
Smyd4-1	NP_610500.2	SET	217..>252	CDD:394802	9/44 (20%)
		zf-MYND	258..298	CDD:460312	20/40 (50%)
		SET	<359..549	CDD:394802	59/199 (30%)