DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dao and SmydA-3

DIOPT Version :9

Sequence 1:	NP_001260462.1	Gene:	dao / 34891	FlyBaseID:	FBgn0028862	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001260366.1	Gene:	SmydA-3 / 34502	FlyBaseID:	FBgn0262599	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	107/503 - (21%)
Similarity:	158/503 - (31%)	Gaps:	151/503 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 AVAKNALIFESEAVAMVPSGNCR-VCDYCGITQFIPFP------CIYCSNRLVVYCSRQCRFKHA 388
            |:..:.|:.|....|:.|..|.. ||..|    :.|.|      |..|...|.|.|::|....|
  Fly    29 AIRGHGLLIEELPFAVGPKCNGPVVCLGC----YEPNPDPEEELCSECGWPLCVECAQQADNAH- 88

  Fly   389 AIHAVECFGHQIELFESFGEVFGMPRLLQLAFRMLITGLPELLGHCRK----KPTLSKLWSAING 449
              ..:||    .:|.::....|               .||....||.:    .|....|....|
  Fly    89 --FRLEC----SQLKDARARFF---------------RLPSGSRHCPQLDCIMPLRVLLAKEAN- 131

  Fly   450 GLQERQDIAYSAVLRLERLKEERPTDTVIALALAAHILSIYLSKCTTFFDQLEKSLPTASRMSSA 514
              .||.|   :.|..:|..||||..|..:..|...:|.......|     ||      |:|.|.
  Fly   132 --PERWD---NEVAPMEHHKEERQRDADVWHADRVNIAQYLRGPC-----QL------ANRFSE- 179

  Fly   515 EWELLCAALLMRHIGQLRHRSLTACRSFVLPADPHVFSPLNEFQLWAA---PMRLQEGHLHLLAG 576
                   .|:|:.:|.|.                     :|.|:..:.   |:|....:..:||.
  Fly   180 -------ELIMQVVGVLE---------------------VNAFEARSPKGYPLRCLFPYTGILAH 216

  Fly   577 E-VAVVSYSVYPDTLNLCRHSCSSTICAKFSGRTVTALALLDLPAGSGIYNCFA---GGNFQQLP 637
            . |...|.|:||.                 .|..:...|::||..|..:::.:.   .|..|
  Fly   217 NCVPNTSRSIYPS-----------------EGYKIRLRAMVDLEEGQPLHHSYTYTLDGTAQ--- 261

  Fly   638 REERTKQLLESGIRCHCNAC----QL-THSDDQFHKFHRYRCDNPNCMEIFTPNALPHAPSLRWW 697
            |::..||  .....|.|..|    :| ||       |...:|.  .|.|.|.....|..|...|
  Fly   262 RQKHLKQ--GKFFTCQCERCLDPTELGTH-------FSSLKCG--QCAEGFQVPRQPTEPDTSW- 314

  Fly   698 LSEEYTQPEFNGADLIMCPHCG----EYQKLEWFWAFTTSLIDCELIEERCKLYAAIERA----E 754
                            .|.:||    ....|....:..:.:...:.:....|....|||.    :
  Fly   315 ----------------NCANCGSDTSNADALAMLQSLQSEVNAVQALPMAAKRLEEIERLLRKYK 363

  Fly   755 NQLMDLHECKVALARLLLEQCLMVHREGATVLDDWEFNKLGSILRSVL 802
            :.|..||.....|.:||:|....|.......|.|.:..:...:.|.||
  Fly   364 SLLHPLHFIATGLRQLLIEMYGRVQGYEMVQLPDHQLERKAELCRQVL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dao	NP_001260462.1	TPR_11	165..235	CDD:290150
		TPR repeat	200..235	CDD:276809
		TPR repeat	243..270	CDD:276809
		zf-MYND	355..395	CDD:280009	11/45 (24%)
SmydA-3	NP_001260366.1	SET	<207..252	CDD:250181	12/61 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810