DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dao and Smyd4

DIOPT Version :9

Sequence 1:	NP_001260462.1	Gene:	dao / 34891	FlyBaseID:	FBgn0028862	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001099280.1	Gene:	Smyd4 / 287525	RGDID:	1307369	Length:	801	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	157/756 - (20%)
Similarity:	254/756 - (33%)	Gaps:	201/756 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 REAGNDSYRKERHPLKASDLFTEAIFLAPAR-NTLAAALAHANRSLVLFDCGLYAESYDDCLCAL 233
            ||.||..: :|:..:.|:.|:::.:  :.:| ||...:|.:||||..||..|.:.....|.:.|.
  Rat    72 REEGNKRF-QEKEYMGAAVLYSKGV--SHSRPNTEDISLCYANRSAALFHLGQHEACLKDIVRAG 133

  Fly   234 DLGYPEEYLPLIKLRQAACALKLRNFALCEEHLHELLHIELNQVFEARTHELWHQCEVLKVERFE 298
            ..||||...|.:.:|:..|   |.|....:|....:..:|.:...:.......||.....|::.:
  Rat   134 MHGYPERLQPKLMIRKTEC---LVNLGRLQEARQTISDLENSLTTKPTLMPSSHQILQRNVQQLK 195

  Fly   299 MAVQTGDDLDIND----SKAFE----------IAWLDNSSSLHT----------TRAVAKNALIF 339
            |.:|..:.|..:.    :||.|          |:....|.||.|          |:.:....|:.
  Rat   196 MKIQEKETLPESFPAALTKALEDMALGEENKQISGASLSVSLCTDPLKGRHLVATKDILPGELLV 260

  Fly   340 ESEAVA-------MVPSGNC-------RV------CDYCGITQFIPFPCIYCSNRLVVYCSRQC- 383
            :.:|..       |.|..:|       ||      |..|........||..||  ...|||::|
  Rat   261 KEDAFVSVLNPGEMPPLRHCLENKWDTRVTSADLYCHRCLRHTLATVPCGGCS--YAKYCSQECV 323

  Fly   384 --RFKHAAIHAVEC-----------FGH---QIELFESFGEVFGMPRLLQLAFRMLITGLPELLG 432
              .:.|  .|:.||           |.|   ::.|...|.:|..:.|::........|.|||
  Rat   324 QQAWDH--YHSTECSLGGLLLTLGVFCHVALRMTLLARFEDVDRVIRMICDKTGRKDTCLPE--- 383

  Fly   433 HCRKKPTLSKLWSAINGGLQERQDIAYSAVLRLERLKEERPTDTVIALALAAHILSIYLSKCTTF 497
                ...|.|.:...|.|..|...         |..:...|...|             ..|....
  Rat   384 ----SKDLVKTFGYTNQGESEENS---------ETCEPSIPGCNV-------------NGKYENN 422

  Fly   498 FDQLEKSLPTASRMSSAEWELLCAALLMRHIGQLRHRSLTACRSFVLPADPHVFSP--LNEFQLW 560
            :|.:...||...: .|.|.:.:||..:.....||:..||.|..:.:........:|  ..:..:|
  Rat   423 YDAVLSLLPHTEK-HSPEHKFICAVSVSALCRQLKATSLQAQTTGLKSPRLKAVTPGLCTDLTVW 486

  Fly   561 AAPMRLQEGHLHLLAGEVAVVSYS------------------VYPDTLNLCRHSCSSTICAKFSG 607
            ...|......|...|..:..:.|:                  |:| .::|..||||......|:.
  Rat   487 GVAMLQHMLQLQCNAQAITSICYAGSKESIITNSRQVRLATGVFP-VVSLLNHSCSPNTSVSFTS 550

  Fly   608 RTVTALALLDLPAGSGIYNCFAGGNFQQLPREER-----TKQLLESG--IRCHCNACQLTHSDDQ 665
            ...|..|...:..|..|.:|:.       |.|.|     .:|.|.|.  ..|.|.||   |::
  Rat   551 TVATIRAAQQIAKGQEILHCYG-------PHESRMGVAERQQRLSSQYFFDCSCPAC---HAE-- 603

  Fly   666 FHKFHRYRCDNPNCMEIFTPNALPHAPSLRWWLSEEY----TQPEFNGADLIMCPH--CGEYQKL 724
                                 .|..|.:.||   |.:    .:....|.|::.|.:  |
  Rat   604 ---------------------TLRAAVAPRW---EAFCCNTCRVPMQGNDVLSCSNESC------ 638

  Fly   725 EWFWAFTTSLIDCELIEERCKLYAAI---------ERAENQLMDLHECKVALARLLLEQCLMVHR 780
                  |.|:....|:.....|...:         :|.|..:..|.||:.|....|..:..::..
  Rat   639 ------TNSVSRDRLVSRLQDLQQQVHTAQKLLRSDRPEQAIQQLLECQRAAENFLSAEHTVLGE 697

  Fly   781 ------EGATVLDDWEFNKLGSILRSVLPSVMAQYGGQSIE 815
                  :....|.||  .:..:.::..|..|.|::|..|:|
  Rat   698 IEDGLAQAYATLGDW--RQSAAHVQKSLQVVEARHGPSSVE 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dao	NP_001260462.1	TPR_11	165..235	CDD:290150	20/65 (31%)
		TPR repeat	200..235	CDD:276809	13/35 (37%)
		TPR repeat	243..270	CDD:276809	6/26 (23%)
		zf-MYND	355..395	CDD:280009	12/42 (29%)
Smyd4	NP_001099280.1	TPR_11	68..132	CDD:290150	19/62 (31%)
		TPR repeat	68..96	CDD:276809	7/26 (27%)
		TPR repeat	101..136	CDD:276809	12/34 (35%)
		zf-MYND	296..335	CDD:280009	12/42 (29%)
		SET	<526..572	CDD:279228	13/46 (28%)
		TPR_12	692..>748	CDD:290160	9/47 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342707
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1278034at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46165
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850