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Protein Alignment dao and SMYD4

DIOPT Version :9

Sequence 1:	NP_001260462.1	Gene:	dao / 34891	FlyBaseID:	FBgn0028862	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_443160.2	Gene:	SMYD4 / 114826	HGNCID:	21067	Length:	804	Species:	Homo sapiens

Alignment Length:	833	Identity:	183/833 - (21%)
Similarity:	279/833 - (33%)	Gaps:	252/833 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 PVLDFRPHVL-KW-------------FQHLR----HQTGHFKSEEE--SRRL------------- 169
            ||.:::.::| ||             .:.||    |.:...:.|:|  .:||
Human     4 PVDEWKSYLLQKWASLPTSVQVTISTAETLRDIFLHSSSLLQPEDELFLKRLSKGYLVGKDSDAP 68

  Fly   170 ---REAGNDSYRKERHPLKASDLFTEAIFLAPAR-NTLAAALAHANRSLVLFDCGLYAESYDDCL 230
               ||.||..: :|:....|:.|:::.:  :.:| ||...:|.|||||..||..|.|.....|..
Human    69 LFYREEGNKKF-QEKDYTGAAVLYSKGV--SHSRPNTEDMSLCHANRSAALFHLGQYETCLKDIN 130

  Fly   231 CALDLGYPEEYLPLIKLRQAACALKLRNFALCEEHLHELLHIELNQVFEARTHELWHQCEVLKVE 295
            .|...||||...|.|.||:|.|.:.|...   :|....:..:|.|........::..|.....:.
Human   131 RAQTHGYPERLQPKIMLRKAECLVALGRL---QEASQTISDLERNFTATPALADVLPQTLQRNLH 192

  Fly   296 RFEMAVQTGDDLDINDSKAFEIA---------------WLDNSSS-------------LHTTRAV 332
            |.:|.:|..|.|    :::|..|               .|.|:||             |..|:.:
Human   193 RLKMKMQEKDSL----TESFPAALAKTLEDAALREENEQLSNASSSIGLCVDPLKGRCLVATKDI 253

  Fly   333 AKNALIFESEA-VAMVPSG-------------NCRV------CDYCGITQFIPFPCIYCSNRLVV 377
            ....|:.:.:| |:::..|             :.||      |..|........||..||  ...
Human   254 LPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATVPCDGCS--YAK 316

  Fly   378 YCSRQCRFKHA--AIHAVEC-----------FGH---QIELFESFGEVFGMPRLLQLAFRMLITG 426
            |||::| .:.|  ..|..||           |.|   ::.|...|.:|           |.:||.
Human   317 YCSQEC-LQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGFEDV-----------RKIITK 369

  Fly   427 LPELLGH---CRKKPTLSKLWSAINGGLQERQ-------------DI------AYSAVLRLERLK 469
            |.:.:.:   |  .|..:.....:|.||.|.:             ||      .|:||..|....
Human   370 LCDKISNKDIC--LPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHT 432

  Fly   470 EERPTDTVIALALAAHILSIYLSKCTTFFDQLE----KSLPT-----ASRMSSAEWELLCAALLM 525
            |....:.....||....|      |.    |||    :::||     :|::.:|....||..:.:
Human   433 ENHSPEHKFLCALCVSAL------CR----QLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTI 487

  Fly   526 RHIGQLRHRSLTACRSFVLPADPHVFSPLNEFQLWAAPMRLQEGHLHLLAGEVAVVSYSVYPDTL 590
            ..:..|||.....|.:..:....|. .|.......:..:||..|               ::| .:
Human   488 WGVAMLRHMLQLQCNAQAMTTIQHT-GPKGSIVTDSRQVRLATG---------------IFP-VI 535

  Fly   591 NLCRHSCSSTICAKFSGRTVTALALLDLPAGSGIYNCFAGGNFQQLPREERTKQLLESGIRCHCN 655
            :|..||||......|.....|..|...:..|..|.:|:.....:....|.:.|...:....|.|.
Human   536 SLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACP 600

  Fly   656 ACQLTHSDDQFHKFHRYRCDNPNCMEIFTPNALPHAPSLRWWLSEEYTQPEFNGADLIMC--PHC 718
            |||.        :.||... .|. .|.|..|:. .||              ..|.|::.|  ..|
Human   601 ACQT--------EAHRMAA-GPR-WEAFCCNSC-GAP--------------MQGDDVLRCGSRSC 640

  Fly   719 GE---------------------YQKLEWFWAFTTSLIDCELIEERCKLYAAIERAENQLMDLHE 762
            .|                     .|||         |.|.||.....:|......||:.|...|.
Human   641 AESAVSRDHLVSRLQDLQQQVRVAQKL---------LRDGELERAVQRLSGCQRDAESFLWAEHA 696

  Fly   763 CKVALARLLLEQCLMVHREGATVLDDWEFNKLGSILRSVLPSVMAQYGGQSIE 815
            ....:|..|...|        ..|.||:  |..:.|:..|..|..::|..|:|
Human   697 VVGEIADGLARAC--------AALGDWQ--KSATHLQRSLYVVEVRHGPSSVE 739

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.