Protein Alignment dao and SMYD4

DIOPT Version :10

• Sequence 1: NP_609742.1
• Gene: dao / 34891
• FlyBaseID: FBgn0028862
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_443160.2
• Gene: SMYD4 / 114826
• HGNCID: 21067
• Length: 804
• Species: Homo sapiens
• Alignment Length: 833
• Identity: 183/833 - (21%)
• Similarity: 279/833 - (33%)
• Gaps: 252/833 - (30%)

  Fly   138 PVLDFRPHVL-KW-------------FQHLR----HQTGHFKSEEE--SRRL------------- 169
            ||.:::.::| ||             .:.||    |.:...:.|:|  .:||
Human     4 PVDEWKSYLLQKWASLPTSVQVTISTAETLRDIFLHSSSLLQPEDELFLKRLSKGYLVGKDSDAP 68

  Fly   170 ---REAGNDSYRKERHPLKASDLFTEAIFLAPAR-NTLAAALAHANRSLVLFDCGLYAESYDDCL 230
               ||.||..: :|:....|:.|:::.:  :.:| ||...:|.|||||..||..|.|.....|..
Human    69 LFYREEGNKKF-QEKDYTGAAVLYSKGV--SHSRPNTEDMSLCHANRSAALFHLGQYETCLKDIN 130

  Fly   231 CALDLGYPEEYLPLIKLRQAACALKLRNFALCEEHLHELLHIELNQVFEARTHELWHQCEVLKVE 295
            .|...||||...|.|.||:|.|.:.|...   :|....:..:|.|........::..|.....:.
Human   131 RAQTHGYPERLQPKIMLRKAECLVALGRL---QEASQTISDLERNFTATPALADVLPQTLQRNLH 192

  Fly   296 RFEMAVQTGDDLDINDSKAFEIA---------------WLDNSSS-------------LHTTRAV 332
            |.:|.:|..|.|    :::|..|               .|.|:||             |..|:.:
Human   193 RLKMKMQEKDSL----TESFPAALAKTLEDAALREENEQLSNASSSIGLCVDPLKGRCLVATKDI 253

  Fly   333 AKNALIFESEA-VAMVPSG-------------NCRV------CDYCGITQFIPFPCIYCSNRLVV 377
            ....|:.:.:| |:::..|             :.||      |..|........||..||  ...
Human   254 LPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATVPCDGCS--YAK 316

  Fly   378 YCSRQCRFKHA--AIHAVEC-----------FGH---QIELFESFGEVFGMPRLLQLAFRMLITG 426
            |||::| .:.|  ..|..||           |.|   ::.|...|.:|           |.:||.
Human   317 YCSQEC-LQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGFEDV-----------RKIITK 369

  Fly   427 LPELLGH---CRKKPTLSKLWSAINGGLQERQ-------------DI------AYSAVLRLERLK 469
            |.:.:.:   |  .|..:.....:|.||.|.:             ||      .|:||..|....
Human   370 LCDKISNKDIC--LPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHT 432

  Fly   470 EERPTDTVIALALAAHILSIYLSKCTTFFDQLE----KSLPT-----ASRMSSAEWELLCAALLM 525
            |....:.....||....|      |.    |||    :::||     :|::.:|....||..:.:
Human   433 ENHSPEHKFLCALCVSAL------CR----QLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTI 487

  Fly   526 RHIGQLRHRSLTACRSFVLPADPHVFSPLNEFQLWAAPMRLQEGHLHLLAGEVAVVSYSVYPDTL 590
            ..:..|||.....|.:..:....|. .|.......:..:||..|               ::| .:
Human   488 WGVAMLRHMLQLQCNAQAMTTIQHT-GPKGSIVTDSRQVRLATG---------------IFP-VI 535

  Fly   591 NLCRHSCSSTICAKFSGRTVTALALLDLPAGSGIYNCFAGGNFQQLPREERTKQLLESGIRCHCN 655
            :|..||||......|.....|..|...:..|..|.:|:.....:....|.:.|...:....|.|.
Human   536 SLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACP 600

  Fly   656 ACQLTHSDDQFHKFHRYRCDNPNCMEIFTPNALPHAPSLRWWLSEEYTQPEFNGADLIMC--PHC 718
            |||.        :.||... .|. .|.|..|:. .||              ..|.|::.|  ..|
Human   601 ACQT--------EAHRMAA-GPR-WEAFCCNSC-GAP--------------MQGDDVLRCGSRSC 640

  Fly   719 GE---------------------YQKLEWFWAFTTSLIDCELIEERCKLYAAIERAENQLMDLHE 762
            .|                     .|||         |.|.||.....:|......||:.|...|.
Human   641 AESAVSRDHLVSRLQDLQQQVRVAQKL---------LRDGELERAVQRLSGCQRDAESFLWAEHA 696

  Fly   763 CKVALARLLLEQCLMVHREGATVLDDWEFNKLGSILRSVLPSVMAQYGGQSIE 815
            ....:|..|...|        ..|.||:  |..:.|:..|..|..::|..|:|
Human   697 VVGEIADGLARAC--------AALGDWQ--KSATHLQRSLYVVEVRHGPSSVE 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dao	NP_609742.1	TPR repeat	200..235	CDD:276809	15/35 (43%)
		TPR repeat	243..270	CDD:276809	8/26 (31%)
		SET	<459..657	CDD:394802	43/206 (21%)
SMYD4	NP_443160.2	NlpI	<66..>171	CDD:443815	34/110 (31%)
		TPR repeat	68..96	CDD:276809	7/30 (23%)
		TPR repeat	101..135	CDD:276809	14/33 (42%)
		TPR repeat	143..171	CDD:276809	8/30 (27%)
		SET	239..>269	CDD:394802	5/29 (17%)
		zf-MYND	296..335	CDD:460312	12/41 (29%)
		SET_SMYD4	404..602	CDD:380934	45/224 (20%)
		TPR_12	660..726	CDD:315987	20/84 (24%)
		TPR_12	698..771	CDD:315987	13/52 (25%)