DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT35C and MTPA2

DIOPT Version :9

Sequence 1:	NP_609741.3	Gene:	ZnT35C / 34890	FlyBaseID:	FBgn0028516	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_191440.2	Gene:	MTPA2 / 825050	AraportID:	AT3G58810	Length:	432	Species:	Arabidopsis thaliana

Alignment Length:	403	Identity:	142/403 - (35%)
Similarity:	218/403 - (54%)	Gaps:	58/403 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GRSNNVEVRDHCHR-------ARSEGVDVKAR----RKLIIASILCLVFMIAEIVGGVLSNSLAI 117
            |.::.|.::..|..       |::..::.:.|    |||:||.:||.:|::.|:|||:.:|||||
plant    75 GETSLVGIKKTCGEAPCGFSDAKTSSIEAQERAASMRKLLIAVLLCAIFIVVEVVGGIKANSLAI 139

  Fly   118 ATDAAHLLTDFASFMISLFAIWIAGRPSTQRMSFGWYRAEVIGAMASVFMIWVITGILVWLAIGR 182
            .|||||||:|.|:|.||||::|.:|..:..:.|:|::|.|::||:.|:.|||::.||||:.||.|
plant   140 LTDAAHLLSDVAAFAISLFSLWASGWKANPQQSYGFFRIEILGALVSIQMIWLLAGILVYEAIVR 204

  Fly   183 LISGDYEVNAKIMLITSGLAILVNVIMGVQLQHGHSHGLGGGHGHSHGGSKNASHVQATSTPCSD 247
            |.:|..||...:|...|.:.:|||:.|.:.|.|.|.||.|..|.:.||.|.:..|..|.:....|
plant   205 LNNGSGEVEGSLMFAVSAVGLLVNIAMAILLGHDHGHGHGHSHDNGHGHSHDHGHGIAATEHHHD 269

  Fly   248 SPSQRIEGGVAYAPEDAELPGGGLPTFSYQNTKLVDPTLDLEIAAVLAETAPGSHHHGGPVGREA 312
            |                          .:..::|.|         ||.|.            ::.
plant   270 S--------------------------GHDESQLSD---------VLIEQ------------KKQ 287

  Fly   313 VNMNVRAALIHVIGDVIQSVGVFVAAGVIYFWPEYSIVDPICTFVFSIIVLFTTFTIMKDALLVL 377
            .|:|::.|.:||:||.||||||.:...:|::.||:.|:|.|||.|||:|||.||..::::.|.||
plant   288 RNVNIQGAYLHVLGDSIQSVGVMIGGAIIWYKPEWKILDLICTLVFSVIVLGTTIGMLRNILEVL 352

  Fly   378 MEGTPNYMHYAEVLQIFQGIEGVERVHNLRIWALSINKVALSAHLAIAENANPKRILDAATSAVH 442
            ||.||..:....:.:....||.|..||.|.|||:::.|:.|:.|:.|...|....:||.....:.
plant   353 MESTPREIDPTMLEKGVCEIEEVVAVHELHIWAITVGKLLLACHVKIRPEAEADMVLDKIIDYIK 417

  Fly   443 LRYNFFETTIQIE 455
            ..:|....|||||
plant   418 REHNISHVTIQIE 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CDF	100..457	CDD:273544	130/356 (37%)
ZnT35C	NP_609741.3	Cation_efflux	100..378	CDD:279834	103/277 (37%)
MTPA2	NP_191440.2	CDF	122..430	CDD:273544	128/354 (36%)
MTPA2	NP_191440.2	Cation_efflux	122..353	CDD:279834	103/277 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	205	1.000	Domainoid score	I830
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40855
Inparanoid	1	1.050	254	1.000	Inparanoid score	I1011
OMA	1	1.010	-	-		QHG53838
OrthoDB	1	1.010	-	-		D973492at2759
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	1	1.000	-	-		mtm1128
orthoMCL	1	0.900	-	-		OOG6_100508
Panther	1	1.100	-	-	LDO	PTHR11562
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840