Protein Alignment ZnT35C and SLC30A1

DIOPT Version :10

• Sequence 1: NP_609741.3
• Gene: ZnT35C / 34890
• FlyBaseID: FBgn0028516
• Length: 472
• Species: Drosophila melanogaster
• Sequence 2: NP_067017.2
• Gene: SLC30A1 / 7779
• HGNCID: 11012
• Length: 507
• Species: Homo sapiens
• Alignment Length: 439
• Identity: 118/439 - (26%)
• Similarity: 192/439 - (43%)
• Gaps: 97/439 - (22%)

  Fly    88 RRKLIIASILCLVFMIAEIVGGVLSNSLAIATDAAHLLTDFASFMISLFAIWIAGRP-STQRMSF 151
            |.:|:....|..:||:.|:|...:::|||:.:|:.|:|:|..:.:::|.|...|.|. :||:.:|
Human     8 RGRLLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDVLALVVALVAERFARRTHATQKNTF 72

  Fly   152 GWYRAEVIGAMASVFMIWVITGILVWLAIGRLISGDYEVNAKIMLITSGLA-ILVNVIMGVQL-- 213
            ||.||||:||:.:...:..:...::..||.|.|. .:|:...::::..|:| :|||| :|:.|
Human    73 GWIRAEVMGALVNAIFLTGLCFAILLEAIERFIE-PHEMQQPLVVLGVGVAGLLVNV-LGLCLFH 135

  Fly   214 ---------QHGHSHGLGGGHGHSHGGSKNASHVQATSTPCSD--------SPSQR--------- 252
                     .|||||   |||||.||..| ...|::|....||        .|.|.
Human   136 HHSGFSQDSGHGHSH---GGHGHGHGLPK-GPRVKSTRPGSSDINVAPGEQGPDQEETNTLVANT 196

  Fly   253 -IEGGVAYAPEDAELPGGGLPTFSYQNTKLVDPTLDLEIAAVLAETAPGSHHHGGPVGREAVNMN 316
             ...|:...|.|.|.|..|.......|..||.....:|    |.|...|             .:|
Human   197 SNSNGLKLDPADPENPRSGDTVEVQVNGNLVREPDHME----LEEDRAG-------------QLN 244

  Fly   317 VRAALIHVIGDVIQSVGVFVAAGVIYF-------------------------------------- 343
            :|...:||:||.:.||.|.|.|.|.||
Human   245 MRGVFLHVLGDALGSVIVVVNALVFYFSWKGCSEGDFCVNPCFPDPCKAFVEIINSTHASVYEAG 309

  Fly   344 --WPEYSIVDPICTFVFSIIVLFTTFTIMKDALLVLMEGTPNYMHYAEVLQIFQGIEGVERVHNL 406
              |..|  :||....|...|:|:||:.::|::.|:|::..|..:....:::..:.:||||.||.|
Human   310 PCWVLY--LDPTLCVVMVCILLYTTYPLLKESALILLQTVPKQIDIRNLIKELRNVEGVEEVHEL 372

  Fly   407 RIWALSINKVALSAHLAIAENANPKRILDAATSAVHLRYNFFETTIQIE 455
            .:|.|:.:::..:||:...:..:...:........| .:....||||.|
Human   373 HVWQLAGSRIIATAHIKCEDPTSYMEVAKTIKDVFH-NHGIHATTIQPE 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CzcD	73..455	CDD:440843	117/437 (27%)
SLC30A1	NP_067017.2	CzcD	5..420	CDD:440843	117/437 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..217		25/78 (32%)
		6 X 2 AA approximate repeats of H-G	146..158		10/14 (71%)