Protein Alignment ZnT35C and Slc30a5

DIOPT Version :10

• Sequence 1: NP_609741.3
• Gene: ZnT35C / 34890
• FlyBaseID: FBgn0028516
• Length: 472
• Species: Drosophila melanogaster
• Sequence 2: NP_075023.2
• Gene: Slc30a5 / 69048
• MGIID: 1916298
• Length: 761
• Species: Mus musculus
• Alignment Length: 425
• Identity: 97/425 - (22%)
• Similarity: 161/425 - (37%)
• Gaps: 131/425 - (30%)

  Fly    89 RKLIIASILCLVFMIAEIVGGVLSNSLAIATDAAHLLTDFASFMISLFAIWIAGRPSTQRMSFGW 153
            |::.....|.|:|...|:..|||:|||.:.:|..|:|.|.::.::.|||..::...:|:..|:|:
Mouse   415 RQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGY 479

  Fly   154 YRAEVIGAMASVFMIWVITGILVWLAIGRLISGDYEVNAKIMLITSGLAILVNVIMGVQLQHGHS 218
            .|.|::....:...:.||...:...::.|||... |::..::...|...::||:|......|.||
Mouse   480 GRIEILSGFINGLFLIVIAFFVFMESVARLIDPP-ELDTNMLTPVSVGGLIVNLIGICAFSHAHS 543

  Fly   219 HGLGG----------------GHGHSHGGSKNASHVQATSTPCSDSPSQRIEGGVAYAPEDAELP 267
            ||.|.                ||||.||
Mouse   544 HGHGASQGNCHSDHGHSHHAHGHGHDHG------------------------------------- 571

  Fly   268 GGGLPTFSYQNTKLVDPTLDLEIAAVLAETAPGSHHHGGPVGREAVNMNVRAALIHVIGDVIQSV 332
                                              |.||...|  .:|.|:|...:||:.|.:.|:
Mouse   572 ----------------------------------HSHGFTGG--GMNANMRGVFLHVLADTLGSI 600

  Fly   333 GVFVAAGVI--YFWPEYSIVDPICTFVFSIIVLFTTFTIMKDALLVLMEGTP----NYMHYAEVL 391
            ||.|:..:|  :.|   .|.||:|:...::::..:...::|||..||:...|    ..:|.|  |
Mouse   601 GVIVSTVLIEQFGW---FIADPLCSLFIAVLIFLSVIPLIKDACQVLLLRLPPDHEKELHIA--L 660

  Fly   392 QIFQGIEGVERVHNLRIWALSINKVALSAHLAIAENANPKRILDAAT-----SAVHLRYNFFETT 451
            :..|.|||:....:...|..|.:.||.:.|:.:......:||:...|     :.|:      ..|
Mouse   661 EKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSEVLEQRIVQQVTGILKDAGVN------NLT 719

  Fly   452 IQIED-------------------YTAQMESCLQC 467
            ||:|.                   .|.||||...|
Mouse   720 IQVEKEAYFQHMSGLSTGFHDVLAMTKQMESLKYC 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CzcD	73..455	CDD:440843	90/392 (23%)
Slc30a5	NP_075023.2	CzcD	411..726	CDD:440843	91/395 (23%)
		Mediates homodimerization with SLC30A6. /evidence=ECO:0000250|UniProtKB:Q8TAD4	418..636		64/294 (22%)
		His-rich loop, required for zinc transport. /evidence=ECO:0000250|UniProtKB:Q8TAD4	540..574		13/104 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..576		8/97 (8%)