DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT35C and slc30a6

DIOPT Version :9

Sequence 1:	NP_609741.3	Gene:	ZnT35C / 34890	FlyBaseID:	FBgn0028516	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_991214.1	Gene:	slc30a6 / 402949	ZFINID:	ZDB-GENE-040426-1838	Length:	486	Species:	Danio rerio

Alignment Length:	381	Identity:	69/381 - (18%)
Similarity:	144/381 - (37%)	Gaps:	109/381 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KLIIASIL------CLVFMIAEIVGGVLSNSLAIATDAAHLLTDFASFMISLFAIWIAGRPSTQR 148
            |:::..:|      ||:...:.      :||:|:.......:.|..|.:..|.::|:..:..:|.
Zfish    60 KILLFGVLNVVCTGCLLMWCSS------TNSMALTAYTYLTIFDLFSLITCLLSLWVTMKKPSQI 118

  Fly   149 MSFGWYRAEVIGAMASVFMIWVITGILVWLAIGRLISGDYEVNAKIMLITSGLAILVNVIMGVQL 213
            .|||:.|.||:...:|..::.:.:..::..::.|.:. ..||:...:|:.:.:|:..|::..:.:
Zfish   119 YSFGFQRFEVLAVFSSTVLVQLGSLFILKESVERFVE-QPEVHTGRLLVGTFVALFFNLLTLLSV 182

  Fly   214 QHGHSHGLGGGHGHSHGGSKNASHV---QATSTPCSDSPSQRIEGGVAYAPED-AELPG---GGL 271
                               ||...|   :|.||              ::..|. |:|..   |.:
Zfish   183 -------------------KNKPFVFVSEAAST--------------SWLQEHVADLSRSLCGLI 214

  Fly   272 PTFSYQNTKLVDPTLDLEIAAVLAETAPGSHHHGGPVGREAVNMNVRAALIHVIGDVIQSVGVFV 336
            |..|......::|.:.:.:|                                         |.|
Zfish   215 PALSSFLLPRMNPFVLINLA-----------------------------------------GAF- 237

  Fly   337 AAGVIYFWPE---YSIVDPICTFVFSIIVLFTTFTIMKDALLVLMEGTPNYM--HYAEVLQIFQG 396
            |.|:.|...|   |:.:|.......:::...|.:.:...:..||::.||:::  ...::|:....
Zfish   238 ALGITYMLIEINNYNAMDTASAVAIALMTFGTMYPMSVYSGKVLLQTTPSHVIGQLDKLLREVST 302

  Fly   397 IEGVERVHNLRIWALSINKVALSAHLAIAENANPKRI-------LDAATSA--VHL 443
            ::||..|.|...|.:....:|.|.|:.|..:|:.:.:       |.|..||  ||:
Zfish   303 LDGVLEVRNEHFWTIGFGSLAGSVHVRIRRDADEQMVLAHVWNRLSALVSALTVHV 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CDF	100..457	CDD:273544	65/365 (18%)
ZnT35C	NP_609741.3	Cation_efflux	100..378	CDD:279834	45/287 (16%)
slc30a6	NP_991214.1	Cation_efflux	70..282	CDD:279834	47/293 (16%)
slc30a6	NP_991214.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910