DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT35C and slc30a4

DIOPT Version :9

Sequence 1:	NP_609741.3	Gene:	ZnT35C / 34890	FlyBaseID:	FBgn0028516	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	XP_005173674.1	Gene:	slc30a4 / 393616	ZFINID:	ZDB-GENE-040426-1408	Length:	427	Species:	Danio rerio

Alignment Length:	491	Identity:	152/491 - (30%)
Similarity:	237/491 - (48%)	Gaps:	106/491 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GRTRRSNYGTAPSFH------------LMEQGQPGVN----VVAG--------NGNNNHPATPAT 55
            ||.|.:......|:|            |.|:..|..:    ||:|        ||:.....|...
Zfish     6 GRVRSAFRSRPDSWHLSDAAAFDFSEDLQEEESPRFSRLQVVVSGEAEERPAVNGSARSTLTDDD 70

  Fly    56 PAQIFCLHGRSNNVEVRDHCHRARSEGVDVKARRKLIIASILCLVFMIAEIVGGVLSNSLAIATD 120
            .:.:....| |...|..|.|.|.|.:....:..|||..|::|..:||:.|::||.::|||||.||
Zfish    71 DSLLGASTG-STGPEACDGCQRNREQQRRRRVMRKLGGAAVLYFLFMVGELIGGYVANSLAIMTD 134

  Fly   121 AAHLLTDFASFMISLFAIWIAGRPSTQRMSFGWYRAEVIGAMASVFMIWVITGILVWLAIGRLIS 185
            |.|:|||....::||.|:|::.:|.|.|.:||.:|.||:.|..||.:|:::||:|:..|..|.|.
Zfish   135 ALHMLTDLIGIIVSLLALWLSAKPPTYRFTFGLHRLEVLSAGISVLLIYILTGVLLNEAAQRTIH 199

  Fly   186 GDYEVNAKIMLITSGLAILVNVIMGVQL-QHGHSHGLGGGHGHSHGGSKNASHVQATSTPCSDSP 249
            .|:.::..:||||:.:.:.||::||..| |.||.|..|.|||||||.:.:.|..|.:|
Zfish   200 QDFTIDGDVMLITAAVGVAVNLLMGFLLNQSGHLHSHGHGHGHSHGSAGHGSSDQGSS------- 257

  Fly   250 SQRIEGGVAYAPEDAELPGGGLPTFSYQNTKLVDPTLDLEIAAVLAETAPGSHHHGGPVGREAVN 314
                                                            ..|...||        :
Zfish   258 ------------------------------------------------GQGQRGHG--------S 266

  Fly   315 MNVRAALIHVIGDVIQSVGVFVAAGVIYFWPEYSIVDPICTFVFSIIVLFTTFTIMKDALLVLME 379
            :.||||.||.:||::|||||.:||.::.|.|||.:.|||||::||::|||:||.|::|..::|:|
Zfish   267 LAVRAAFIHALGDLVQSVGVLIAAYIVRFKPEYKLADPICTYLFSVLVLFSTFQIIRDTGIILLE 331

  Fly   380 GTPNYMHYAEVLQIFQGIEGVERVHNLRIWALSINKVALSAHLAIAE---------NANPKRILD 435
            |.|.:|..:.:......::.||.|..|::|||:.:|.|...||.:|.         .|:.:|:|.
Zfish   332 GVPRHMDVSVIRAELLKLQHVECVEELKLWALTADKTAAIVHLQLAPGIVGNWEEVQASARRLLM 396

  Fly   436 AATSAVHLRYNFFETTIQIEDY-TAQMESCLQCNVP 470
            .:....|       .|:|::.: ....::|..|..|
Zfish   397 VSHGVTH-------CTVQLQTHRQGAPQACTHCLSP 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CDF	100..457	CDD:273544	123/366 (34%)
ZnT35C	NP_609741.3	Cation_efflux	100..378	CDD:279834	100/278 (36%)
slc30a4	XP_005173674.1	CDF	114..411	CDD:273544	123/366 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53838
OrthoDB	1	1.010	-	-		D351752at33208
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100508
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.730