DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT35C and ZnT33D

DIOPT Version :9

Sequence 1:	NP_609741.3	Gene:	ZnT35C / 34890	FlyBaseID:	FBgn0028516	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_723732.2	Gene:	ZnT33D / 326167	FlyBaseID:	FBgn0051860	Length:	701	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	226/475 - (47%)
Similarity:	301/475 - (63%)	Gaps:	75/475 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AKRDSGRTRRSNYGTAPSFHLMEQG-----QPGVNVVAGNGNN-------NHPATPATPAQIFCL 62
            :::|.|.........||...::|..     :..|.::..|..|       |..:|     :...:
  Fly   251 SRQDKGSGTSDFQPGAPETPIVENSAVDSDRKAVEIMPENVKNSEEKKIDNSDST-----KTVTI 310

  Fly    63 HGRSNNVEVRD-HCH-RARSEGVDVKARRKLIIASILCLVFMIAEIVGGVLSNSLAIATDAAHLL 125
            .|.|:.....| ||| :.|..|||..|||.||||.|||.:|:|.|::||:|||||||||||||||
  Fly   311 TGHSHITAKWDGHCHFKERETGVDKAARRVLIIACILCTIFLILEVIGGILSNSLAIATDAAHLL 375

  Fly   126 TDFASFMISLFAIWIAGRPSTQRMSFGWYRAEVIGAMASVFMIWVITGILVWLAIGRLISGDYEV 190
            ||.|||:||:.|:.:|||||::|:::||:||||||||.|:|.|||:|||||::||.|.::.|:|:
  Fly   376 TDLASFLISISALHLAGRPSSERLNYGWHRAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQDFEL 440

  Fly   191 NAKIMLITSGLAILVNVIMGVQLQHGHSHGLGGGHGHSHGGSKNASHVQATSTPCSDSPSQRIEG 255
            :||||||||.||||.||||.:||||||||.|.|    .|..||:|..|..:
  Fly   441 DAKIMLITSALAILFNVIMAMQLQHGHSHSLPG----VHKMSKDAGSVLGS-------------- 487

  Fly   256 GVAYAPEDAELPGGGLPTFSYQNTKLVDPTLDLEIAAVLAETAPGSHHHGGPVGREAVNMNVRAA 320
                                 :...|:..::.::.||               .|.|  |:|||||
  Fly   488 ---------------------KMILLLGKSVSMQYAA---------------KGHE--NINVRAA 514

  Fly   321 LIHVIGDVIQSVGVFVAAGVIYFWPEYSIVDPICTFVFSIIVLFTTFTIMKDALLVLMEGTPNYM 385
            :|||:||:|||.||||||.:|:||||::.:|.:||||||::||..||.|::|.|:||||.||::|
  Fly   515 IIHVVGDIIQSFGVFVAALIIFFWPEWAFMDSVCTFVFSVLVLVVTFKILRDVLMVLMEATPDFM 579

  Fly   386 HYAEVLQIFQGIEGVERVHNLRIWALSINKVALSAHLAIAENANPKRILDAATSAVHLRYNFFET 450
            .|.||.|.|..|.|||.||||||||||||||||||||||:::|:|:.||:.||:.:|.|:.||||
  Fly   580 DYEEVKQTFLSISGVEHVHNLRIWALSINKVALSAHLAISKDADPQLILEEATTLIHKRFKFFET 644

  Fly   451 TIQIEDYTAQMESCLQCNVP 470
            |||||:|:..||:|.||..|
  Fly   645 TIQIEEYSPGMENCGQCLSP 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CDF	100..457	CDD:273544	189/356 (53%)
ZnT35C	NP_609741.3	Cation_efflux	100..378	CDD:279834	135/277 (49%)
ZnT33D	NP_723732.2	CDF	350..651	CDD:273544	189/356 (53%)
ZnT33D	NP_723732.2	Cation_efflux	350..572	CDD:279834	135/277 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449442
Domainoid	1	1.000	56	1.000	Domainoid score	I4041
eggNOG	1	0.900	-	-		E1_COG1230
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351752at33208
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	1	1.000	-	-		mtm1128
orthoMCL	1	0.900	-	-		OOG6_100508
Panther	1	1.100	-	-	P	PTHR11562
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X541
	10	9.750