DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT35C and Slc30a8

DIOPT Version :9

Sequence 1:	NP_609741.3	Gene:	ZnT35C / 34890	FlyBaseID:	FBgn0028516	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	XP_008763722.1	Gene:	Slc30a8 / 299903	RGDID:	1308282	Length:	369	Species:	Rattus norvegicus

Alignment Length:	447	Identity:	149/447 - (33%)
Similarity:	223/447 - (49%)	Gaps:	111/447 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EQGQPGVN--VVAGNGNNNHPATPATPAQIFCLHGRSNNVEVRDHCHRA-----RSEGVDVKARR 89
            |:||..||  ...|:|    |..|...| |:             |||.:     ......|.|:.
  Rat    26 ERGQKPVNKDQCPGDG----PERPEAGA-IY-------------HCHNSFKATGNRSSKQVHAKW 72

  Fly    90 KLIIASILCLVFMIAEIVGGVLSNSLAIATDAAHLLTDFASFMISLFAIWIAGRPSTQRMSFGWY 154
            :|..||.:|..||:||:|||.::.|||:.|||||||.|..||::|||::|::.||.::|::||||
  Rat    73 RLCAASAICFFFMVAEVVGGHVAGSLAVLTDAAHLLIDLTSFLLSLFSLWLSSRPPSKRLTFGWY 137

  Fly   155 RAEVIGAMASVFMIWVITGILVWLAIGRLISGDYEVNAKIMLITSGLAILVNVIMGVQLQHGHSH 219
            |||::||:.||..|||:||:||:||..||:..||::.|.||:..||.|:..|:::.:.|...|.
  Rat   138 RAEILGALLSVLCIWVVTGVLVYLACERLLYPDYQIQAGIMITVSGCAVAANIVLTLILHQRHL- 201

  Fly   220 GLGGGHGHSHGGSKNASHVQATSTPCSDSPSQRIEGGVAYAPEDAELPGGGLPTFSYQNTKLVDP 284
                  ||:|                                :||:
  Rat   202 ------GHNH--------------------------------KDAQ------------------- 209

  Fly   285 TLDLEIAAVLAETAPGSHHHGGPVGREAVNMNVRAALIHVIGDVIQSVGVFVAAGVIYFWPEYSI 349
                                        .|.:||||.:|.:|||.||..|.::|.:|||.|:|.:
  Rat   210 ----------------------------ANASVRAAFVHALGDVFQSTSVLISALIIYFKPDYKM 246

  Fly   350 VDPICTFVFSIIVLFTTFTIMKDALLVLMEGTPNYMHYAEVLQIFQGIEGVERVHNLRIWALSIN 414
            .||:|||:.|::.|.:|..|:||..::||||.|..:.|..|.::...::||..||||.||:|::|
  Rat   247 ADPVCTFISSVLALASTVMILKDFSILLMEGVPKGLSYNSVKELLLTVDGVISVHNLHIWSLTVN 311

  Fly   415 KVALSAHLAIAENANPKRILDAATSAVHLRYNFFETTIQIEDYTAQMESCLQCNVPE 471
            :|.||.|:|.|.:.:.:.:......|:...::....|||||....|..|||.|..|:
  Rat   312 QVILSVHVATAASQDSQSVRTGIACALSSSFDLHSLTIQIESAADQDPSCLLCEDPQ 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CDF	100..457	CDD:273544	123/356 (35%)
ZnT35C	NP_609741.3	Cation_efflux	100..378	CDD:279834	94/277 (34%)
Slc30a8	XP_008763722.1	CDF	83..354	CDD:273544	123/356 (35%)
Slc30a8	XP_008763722.1	Cation_efflux	84..274	CDD:279834	94/275 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7815
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53838
OrthoDB	1	1.010	-	-		D351752at33208
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	1	1.000	-	-		otm46093
orthoMCL	1	0.900	-	-		OOG6_100508
Panther	1	1.100	-	-	LDO	PTHR11562
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.790