DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT35C and Slc30a4

DIOPT Version :9

Sequence 1:	NP_609741.3	Gene:	ZnT35C / 34890	FlyBaseID:	FBgn0028516	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_035904.2	Gene:	Slc30a4 / 22785	MGIID:	1345282	Length:	430	Species:	Mus musculus

Alignment Length:	495	Identity:	158/495 - (31%)
Similarity:	250/495 - (50%)	Gaps:	112/495 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RNEDTPIAKRDSGRTRRSNYGTAPSFHLMEQGQPGVN----VVAGNG--------NNNHPA---- 51
            |.:|||:...|:.....|:       .:.::|....|    |||.:.        |..|||
Mouse    15 RKDDTPLFLNDTSAFDFSD-------EVSDEGLSRFNKLRVVVADDDSEAPERPVNGAHPALQAD 72

  Fly    52 --------TPATPAQIFCLHGRSNNVEVRDHCHRARSEGVDVKARRKLIIASILCLVFMIAEIVG 108
                    .|.|.:|:      |..::..|:|.:.|......|.:.:|.||::|.|:|||.|:||
Mouse    73 DDSLLDQDLPLTNSQL------SLKMDPCDNCSKRRELLKQRKVKTRLTIAAVLYLLFMIGELVG 131

  Fly   109 GVLSNSLAIATDAAHLLTDFASFMISLFAIWIAGRPSTQRMSFGWYRAEVIGAMASVFMIWVITG 173
            |.::|||||.|||.|:|||.::.:::|.|:|::.:..|:|.:||::|.||:.||.||.:::|:.|
Mouse   132 GYMANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMG 196

  Fly   174 ILVWLAIGRLISGDYEVNAKIMLITSGLAILVNVIMGVQL-QHGHSHGLGGGHGHSHGGSKNASH 237
            .|::.|:.|.|..:||:|..:||||:.:.:.||||||..| |.||.|    .|.|||
Mouse   197 FLLYEAVQRTIHMNYEINGDVMLITAAVGVAVNVIMGFLLNQSGHHH----SHAHSH-------- 249

  Fly   238 VQATSTPCSDSPSQRIEGGVAYAPEDAELPGGGLPTFSYQNTKLVDPTLDLEIAAVLAETAPGSH 302
                |.| |:|||....|                                              |
Mouse   250 ----SLP-SNSPSMVSSG----------------------------------------------H 263

  Fly   303 HHGGPVGREAVNMNVRAALIHVIGDVIQSVGVFVAAGVIYFWPEYSIVDPICTFVFSIIVLFTTF 367
            :||..      ::.||||.:|.:||::|||||.:||.:|.|.|||.|.|||||::||::|.||||
Mouse   264 NHGQD------SLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTF 322

  Fly   368 TIMKDALLVLMEGTPNYMHYAEVLQIFQGIEGVERVHNLRIWALSINKVALSAHLAIAENANPKR 432
            .|:.|.:::::||.|::::...:.:....||.|..|.:|.||:|:..|.....|:.:...::.|
Mouse   323 RIIWDTVVIILEGVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKSTAIVHMQLIPGSSSK- 386

  Fly   433 ILDAATSAVHLRYNFF---ETTIQIEDYTAQ-MESCLQCN 468
            ..:..:.|.||..|.|   :.|||::.|..: :.:|..|:
Mouse   387 WEEVQSKAKHLLLNTFGMYKCTIQLQSYRQEVIRTCANCH 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CDF	100..457	CDD:273544	127/360 (35%)
ZnT35C	NP_609741.3	Cation_efflux	100..378	CDD:279834	105/278 (38%)
Slc30a4	NP_035904.2	CDF	123..414	CDD:273544	127/360 (35%)
		Cation_efflux	123..333	CDD:279834	105/278 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..264		11/77 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53838
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100508
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720