DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT35C and Slc30a10

DIOPT Version :9

Sequence 1:	NP_609741.3	Gene:	ZnT35C / 34890	FlyBaseID:	FBgn0028516	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_001028458.1	Gene:	Slc30a10 / 226781	MGIID:	2685058	Length:	470	Species:	Mus musculus

Alignment Length:	425	Identity:	99/425 - (23%)
Similarity:	182/425 - (42%)	Gaps:	83/425 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KLIIASILCLVFMIAEIVGGVLSNSLAIATDAAHLLTDFASFMISLFAIWIAGR-PSTQRMSFGW 153
            :|:...:|...|.:||:|.|.|.||:|:.:|:.::|:|..|..:.|.:.:||.| |.....::|:
Mouse    10 RLLFMLVLTAAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLGSGYIARRGPRGSSATYGY 74

  Fly   154 YRAEVIGAMASVFMIWVITGILVWLAIGRLISGDYEVNAKIMLITSGLAILVNVIMGVQLQHGHS 218
            .||||:||:::...:..:...:...|:.||...:...:.:::||...|.:.|||: |:.:
Mouse    75 VRAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGALGLAVNVV-GLLI----- 133

  Fly   219 HGLGGGHGHSHGGSKNASHVQATSTPCSDSPSQRIEGGVAYAPED---AELPGGGLPTFSYQNTK 280
                    ....|:..:...:...|..|..|||....|....|::   |..||.|
Mouse   134 --------FQDCGACFSRCTRGRRTRPSQQPSQGDPRGALGCPQEAATATAPGSG---------- 180

  Fly   281 LVDPTLDLEIAAVLAETAPGSHHHGGP-----VGREAVN-----------------MNVRAALIH 323
                     .|..|..::.|.....|.     |..:::|                 :|:|..|:|
Mouse   181 ---------TAVTLRGSSAGRKQQEGATVFSNVAGDSLNTENEPEETTKKEKKSEALNIRGVLLH 236

  Fly   324 VIGDVIQSVGVFVAAGVIYF----------WPEYSIVDPICTFVFSIIVLFTTFTIMKDALLVLM 378
            |:||.:.||.|.:.|.:.|.          |..|  :||..|.|..||:|.:.|.::|:..::|:
Mouse   237 VMGDALGSVVVVITAIIFYVQPLRREDPCNWQCY--IDPSLTVVMVIIILSSAFPLIKETAVILL 299

  Fly   379 EGTPNYMHYAEVLQIFQGIEGVERVHNLRIWALSINKVALSAHLAIAENANPKRILDAAT----- 438
            :..|..::..|::.....:.|:..||.:.||.|...|:..:.|:   ::.......||:.
Mouse   300 QMVPKGVNMEELMSQLSTVPGISSVHEVHIWELISGKIIATLHI---KHQKGTEYQDASRKIREI 361

  Fly   439 ---SAVHLRYNFFETTIQIEDYTAQMESCLQCNVP 470
               :.:|.....|| |:.:::...|.:..|.|:.|
Mouse   362 FHHAGIHNVTIQFE-TLDLKEALEQKDFLLTCSAP 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CDF	100..457	CDD:273544	93/400 (23%)
ZnT35C	NP_609741.3	Cation_efflux	100..378	CDD:279834	76/313 (24%)
Slc30a10	NP_001028458.1	CzcD	10..376	CDD:224151	94/404 (23%)
		Cation_efflux	20..299	CDD:279834	76/313 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..223		17/95 (18%)
		Required for plasma membrane localization. /evidence=ECO:0000250\|UniProtKB:Q6XR72	300..470		20/100 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842499
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740