Protein Alignment ZnT35C and SLC30A8

DIOPT Version :9

• Sequence 1: NP_609741.3
• Gene: ZnT35C / 34890
• FlyBaseID: FBgn0028516
• Length: 472
• Species: Drosophila melanogaster
• Sequence 2: NP_776250.2
• Gene: SLC30A8 / 169026
• HGNCID: 20303
• Length: 369
• Species: Homo sapiens
• Alignment Length: 402
• Identity: 143/402 - (35%)
• Similarity: 216/402 - (53%)
• Gaps: 91/402 - (22%)

  Fly    74 HCH---RARSEGVD--VKARRKLIIASILCLVFMIAEIVGGVLSNSLAIATDAAHLLTDFASFMI 133
            |||   :...:|.:  ..|:.||..||.:|.:|||||:|||.::.|||:.|||||||.|..||::
Human    52 HCHSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLL 116

  Fly   134 SLFAIWIAGRPSTQRMSFGWYRAEVIGAMASVFMIWVITGILVWLAIGRLISGDYEVNAKIMLIT 198
            |||::|::.:|.::|::|||:|||::||:.|:..|||:||:||:||..||:..||::.|.:|:|.
Human   117 SLFSLWLSSKPPSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMIIV 181

  Fly   199 SGLAILVNVIMGVQLQHGHSHGLGGGHGHSHGGSKNASHVQATSTPCSDSPSQRIEGGVAYAPED 263
            |..|:..|:::.|.|   |...|    ||:|      ..|||
Human   182 SSCAVAANIVLTVVL---HQRCL----GHNH------KEVQA----------------------- 210

  Fly   264 AELPGGGLPTFSYQNTKLVDPTLDLEIAAVLAETAPGSHHHGGPVGREAVNMNVRAALIHVIGDV 328
                                                              |.:||||.:|.:||:
Human   211 --------------------------------------------------NASVRAAFVHALGDL 225

  Fly   329 IQSVGVFVAAGVIYFWPEYSIVDPICTFVFSIIVLFTTFTIMKDALLVLMEGTPNYMHYAEVLQI 393
            .||:.|.::|.:|||.|||.|.||||||:|||:||.:|.||:||..::||||.|..::|:.|.::
Human   226 FQSISVLISALIIYFKPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKEL 290

  Fly   394 FQGIEGVERVHNLRIWALSINKVALSAHLAIAENANPKRILDAATSAVHLRYNFFETTIQIEDYT 458
            ...::||..||:|.||:|::|:|.||||:|.|.:.:.:.:......|:...:.....|||:|...
Human   291 ILAVDGVLSVHSLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPV 355

  Fly   459 AQMESCLQCNVP 470
            .|...||.|..|
Human   356 DQDPDCLFCEDP 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CDF	100..457	CDD:273544	128/356 (36%)
		Cation_efflux	100..378	CDD:279834	100/277 (36%)
SLC30A8	NP_776250.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..52		143/402 (36%)
		CDF	83..353	CDD:273544	127/355 (36%)
		Cation_efflux	83..274	CDD:279834	100/276 (36%)
		HXXXXX[HY]NH-motif	197..205		4/11 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	186	1.000	Domainoid score	I3351
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3434
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53838
OrthoDB	1	1.010	-	-		D351752at33208
OrthoFinder	1	1.000	-	-		FOG0000470
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100508
Panther	1	1.100	-	-	LDO	PTHR11562
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3917
SonicParanoid	1	1.000	-	-		X541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.870