Protein Alignment ZnT35C and SLC30A7

DIOPT Version :10

• Sequence 1: NP_609741.3
• Gene: ZnT35C / 34890
• FlyBaseID: FBgn0028516
• Length: 472
• Species: Drosophila melanogaster
• Sequence 2: NP_598003.2
• Gene: SLC30A7 / 148867
• HGNCID: 19306
• Length: 376
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 93/391 - (23%)
• Similarity: 176/391 - (45%)
• Gaps: 65/391 - (16%)

  Fly    86 KARRKLIIASILCLVFMIAEIVGGVLSNSLAIATDAAHLLTDFASFMISLFAIWIAGRPSTQRMS 150
            |..|.|.....|.|.|...|::.|:.||.|.:.:|:.|:..|..:.:..|.|..|:........|
Human    33 KTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFS 97

  Fly   151 FGWYRAEVI-GAMASVFMIWVITGILVWL-AIGRLISGDYEVNAKIMLITSGLAILVNVIMGVQL 213
            :|:.||||: |.:..:|:|:  |...::. .:.|.::.. :|:.:.:|:.|.|..:||:|.....
Human    98 YGYVRAEVLAGFVNGLFLIF--TAFFIFSEGVERALAPP-DVHHERLLLVSILGFVVNLIGIFVF 159

  Fly   214 QH-GHSHGLGGGHGHSH---GGSKNASHVQATSTPCSDSPSQRIEGGVAYAPEDAELPGGGLPTF 274
            :| ||.|..|.||||||   .|:.:.:|.....  |.   |..::.|.|::.:.|.  |.|
Human   160 KHGGHGHSHGSGHGHSHSLFNGALDQAHGHVDH--CH---SHEVKHGAAHSHDHAH--GHG---- 213

  Fly   275 SYQNTKLVDPTLDLEIAAVLAETAPGSHHHGGPVGREAVNMN---VRAALIHVIGDVIQSVGVFV 336
                                     ..|.|.||..:|....:   ::...:|::.|.:.|:||..
Human   214 -------------------------HFHSHDGPSLKETTGPSRQILQGVFLHILADTLGSIGVIA 253

  Fly   337 AA------GVIYFWPEYSIVDPICTFVFSIIVLFTTFTIMKDALLVLMEGTPNYMHYA--EVLQI 393
            :|      |::       |.||||:.:.:|:::.:...::::::.:||:.||..:..:  :..|.
Human   254 SAIMMQNFGLM-------IADPICSILIAILIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQR 311

  Fly   394 FQGIEGVERVHNLRIWALSINKVALSAHLAIAENANPKRILDAATSAVHLRYNFFETTIQIEDYT 458
            .|.::||..:.....|.|..:....:..|.:|.:|:.:.|| :.|..:..:....:..:|| |:.
Human   312 VQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAPDADARWIL-SQTHNIFTQAGVRQLYVQI-DFA 374

  Fly   459 A 459
            |
Human   375 A 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT35C	NP_609741.3	CzcD	73..455	CDD:440843	90/385 (23%)
SLC30A7	NP_598003.2	CzcD	31..354	CDD:440843	88/367 (24%)
		His-rich loop	161..218		21/92 (23%)
		ureE	<182..219	CDD:237323	9/72 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..226		10/65 (15%)