DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4168 and LRIG2

DIOPT Version :9

Sequence 1:NP_001285953.1 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster
Sequence 2:NP_055628.1 Gene:LRIG2 / 9860 HGNCID:20889 Length:1065 Species:Homo sapiens


Alignment Length:582 Identity:149/582 - (25%)
Similarity:238/582 - (40%) Gaps:157/582 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   404 PSAFEGLTET-----LEYLDLERNRLTTVPV----ALSSLHHLKYLYLTSNQISQLNNLPSFTEN 459
            |:|..||...     :..||..|.:|   |.    |||.|                  ||..|  
Human    36 PAAGAGLCPAPCSCRIPLLDCSRRKL---PAPSWRALSGL------------------LPPDT-- 77

  Fly   460 LRVLSLSGNNFSMIPVLGLKNYTQLSYLNMGYNSITDIPEGIFAVDSWGSNLQTILLRNNKITHL 524
             .:|..|.|..|...: .|::.| |..:.|.||.:|:||                          
Human    78 -AILDFSHNRLSNWNI-SLESQT-LQEVKMNYNELTEIP-------------------------- 113

  Fly   525 HLGSFAGLEQIQEISLSFNDITIHHPLVFENVSRTLKILELSFAVFPARSLESLDPLDALLPLSQ 589
            :.|     |....|:|    :::.|.::.|..::.|:.       :||  |||||          
Human   114 YFG-----EPTSNITL----LSLVHNIIPEINAQALQF-------YPA--LESLD---------- 150

  Fly   590 LIWLGLDNNNLKQVSNESFAQMRELSYINLSFNQLKTLPRGLFQSDAHSHLVEIDLSYNGLERLE 654
                 |.:|.:.::...||.:| :|.|:|||.|::.||..|.|.:.:.|.|| :.|:.|.:..:.
Human   151 -----LSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLV-VKLNRNRMSMIP 208

  Fly   655 AQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISHGAFTVLPNLAALDLMH 719
            .:.| .|..||.|.|:.||::.:....|..|:.||.|.:..|.:..:..|||..|.|:..|:|.|
Human   209 PKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEH 272

  Fly   720 NQLCSLSLKSFLYVSNTTTPLRLNVSHNHIASFYDELSSYMYIYQLDISHNHVTK-SDSFTNLAN 783
            |.|..:: |.:||      .||:                   :.||.:|.|.:.: |........
Human   273 NNLTRVN-KGWLY------GLRM-------------------LQQLYVSQNAIERISPDAWEFCQ 311

  Fly   784 TLRFLNLAHNQLGSLQSHAFGDLEFLEILNVAHNNLTSLRRRSFQGLNSLQELDLSHNQLD---Q 845
            .|..|:|::|||..|...||..|..||.||:..|.:|.:....|:.|::||.|||.:|::.   :
Human   312 RLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIE 376

  Fly   846 LQVEQFSNLRKLRILRINSNRLRALPREVFMNTR-LEFLDIAENQLSVWPVPAFTDIGFTLRSIQ 909
            ...|.|:.|..|..|.:..|:::::.::.|:... ||.||:..|               .:.|||
Human   377 DASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNN---------------AIMSIQ 426

  Fly   910 MSHNNLEYLDASMFINSQFLYDISLARNRITILPDNTFSFLNNLT-------------NLDL 958
            .:..:..:|...:...|..|.|..| :..:..|.||.|....|::             |:||
Human   427 ENAFSQTHLKELILNTSSLLCDCHL-KWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDL 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4168NP_001285953.1 leucine-rich repeat 99..118 CDD:275380
LRR_8 121..181 CDD:290566
LRR_RI 122..350 CDD:238064
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
LRR_8 265..322 CDD:290566
leucine-rich repeat 266..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..338 CDD:275380
LRR_RI 315..546 CDD:238064 33/150 (22%)
leucine-rich repeat 339..365 CDD:275380
LRR_8 365..424 CDD:290566 7/24 (29%)
leucine-rich repeat 366..388 CDD:275380
leucine-rich repeat 389..412 CDD:275380 4/7 (57%)
LRR_8 413..470 CDD:290566 15/65 (23%)
leucine-rich repeat 414..436 CDD:275380 9/25 (36%)
leucine-rich repeat 437..459 CDD:275380 3/21 (14%)
leucine-rich repeat 460..483 CDD:275380 5/22 (23%)
LRR_8 482..545 CDD:290566 12/62 (19%)
leucine-rich repeat 484..510 CDD:275380 7/25 (28%)
leucine-rich repeat 511..534 CDD:275380 1/22 (5%)
leucine-rich repeat 535..589 CDD:275380 12/53 (23%)
LRR_RI 588..891 CDD:238064 90/307 (29%)
LRR_8 588..650 CDD:290566 20/61 (33%)
leucine-rich repeat 590..613 CDD:275380 5/22 (23%)
leucine-rich repeat 614..639 CDD:275380 10/24 (42%)
LRR_8 638..698 CDD:290566 19/59 (32%)
leucine-rich repeat 640..663 CDD:275380 6/22 (27%)
leucine-rich repeat 664..687 CDD:275380 8/22 (36%)
LRR_8 688..749 CDD:290566 19/60 (32%)
leucine-rich repeat 688..711 CDD:275380 8/22 (36%)
leucine-rich repeat 712..735 CDD:275380 8/22 (36%)
leucine-rich repeat 740..783 CDD:275380 7/43 (16%)
LRR_8 784..843 CDD:290566 24/58 (41%)
leucine-rich repeat 785..808 CDD:275380 10/22 (45%)
leucine-rich repeat 809..832 CDD:275380 8/22 (36%)
LRR_RI <827..1053 CDD:238064 36/149 (24%)
LRR_8 832..890 CDD:290566 18/61 (30%)
leucine-rich repeat 833..856 CDD:275380 9/25 (36%)
leucine-rich repeat 857..879 CDD:275380 4/21 (19%)
leucine-rich repeat 880..900 CDD:275380 5/19 (26%)
LRR_8 904..963 CDD:290566 16/68 (24%)
leucine-rich repeat 905..928 CDD:275380 5/22 (23%)
leucine-rich repeat 929..952 CDD:275380 7/22 (32%)
leucine-rich repeat 953..977 CDD:275380 3/19 (16%)
leucine-rich repeat 978..1020 CDD:275380
LRR_8 1019..1074 CDD:290566
leucine-rich repeat 1045..1068 CDD:275380
leucine-rich repeat 1069..1090 CDD:275380
leucine-rich repeat 1091..1114 CDD:275380
leucine-rich repeat 1115..1161 CDD:275380
leucine-rich repeat 1162..1190 CDD:275380
LRIG2NP_055628.1 LRR_RI <46..205 CDD:238064 59/245 (24%)
LRR 1 76..97 6/24 (25%)
LRR 2 98..119 10/52 (19%)
leucine-rich repeat 99..121 CDD:275380 9/52 (17%)
LRR_8 120..179 CDD:290566 23/87 (26%)
LRR 3 121..142 5/24 (21%)
leucine-rich repeat 122..145 CDD:275378 5/33 (15%)
LRR 4 145..166 10/37 (27%)
leucine-rich repeat 146..168 CDD:275380 10/37 (27%)
LRR_8 168..251 CDD:290566 29/84 (35%)
LRR 5 168..189 10/20 (50%)
leucine-rich repeat 169..192 CDD:275380 10/22 (45%)
LRR 6 193..214 6/22 (27%)
leucine-rich repeat 194..216 CDD:275380 6/23 (26%)
LRR 7 216..237 7/20 (35%)
leucine-rich repeat 217..240 CDD:275380 8/22 (36%)
LRR_8 240..299 CDD:290566 23/84 (27%)
LRR 8 240..261 7/20 (35%)
leucine-rich repeat 241..264 CDD:275380 8/22 (36%)
LRR 9 264..285 9/27 (33%)
leucine-rich repeat 265..288 CDD:275380 9/29 (31%)
LRR_RI 266..492 CDD:238064 67/264 (25%)
LRR 10 288..309 5/39 (13%)
leucine-rich repeat 289..312 CDD:275380 5/22 (23%)
LRR_8 312..371 CDD:290566 24/58 (41%)
LRR 11 312..333 9/20 (45%)
leucine-rich repeat 313..336 CDD:275380 10/22 (45%)
LRR 12 336..357 7/20 (35%)
leucine-rich repeat 337..360 CDD:275380 8/22 (36%)
LRR_8 359..422 CDD:290566 18/77 (23%)
LRR 13 360..382 7/21 (33%)
leucine-rich repeat 361..385 CDD:275380 8/23 (35%)
LRR 14 387..408 4/20 (20%)
leucine-rich repeat 388..411 CDD:275380 4/22 (18%)
LRR 15 411..432 8/35 (23%)
leucine-rich repeat 412..434 CDD:275380 8/36 (22%)
LRRCT 445..493 CDD:214507 11/44 (25%)
Ig 502..598 CDD:299845
IG 504..598 CDD:214652
I-set 602..692 CDD:254352
Ig_1 619..693 CDD:143240
I-set 696..783 CDD:254352
Ig 714..783 CDD:299845
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..990
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1003..1040
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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