DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4168 and RLP53

DIOPT Version :9

Sequence 1:	NP_001285953.1	Gene:	CG4168 / 34889	FlyBaseID:	FBgn0028888	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_001332753.1	Gene:	RLP53 / 832764	AraportID:	AT5G27060	Length:	958	Species:	Arabidopsis thaliana

Alignment Length:	945	Identity:	232/945 - (24%)
Similarity:	357/945 - (37%)	Gaps:	240/945 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 LERLDLGQN--------CIENLESDYFQQNYSDVHLRALNLEQN-FVTQLPEAVFKATGIAHLVL 394
            |..|||..|        .||||.           ||..|:|..| |..|:..::...:.:.:|.|
plant   124 LTTLDLSFNDFKGQITSSIENLS-----------HLTYLDLSSNHFSGQILNSIGNLSRLTYLNL 177

  Fly   395 AFNAISRVHPSAFEGLTETLEYLDLERNR-LTTVPVALSSLHHLKYLYLTSNQISQLNNLPSF-- 456
            ..|..|...||:...|:. |.:|||..|| ....|.::..|.||..|.|.||:.|  ..:||.
plant   178 FDNQFSGQAPSSICNLSH-LTFLDLSYNRFFGQFPSSIGGLSHLTTLSLFSNKFS--GQIPSSIG 239

  Fly   457 -TENLRVLSLSGNNFS-MIPVLGLKNYTQLSYLNM-GYNSITDIPEGIFAVDSWGSNLQTILLRN 518
             ..||..|.||.|||| .||.. :.|.:||::|.: ..|.:.:||
plant   240 NLSNLTTLDLSNNNFSGQIPSF-IGNLSQLTFLGLFSNNFVGEIP-------------------- 283

  Fly   519 NKITHLHLGSFAGLEQIQEISLSFNDITIHHPLVFENVSRTLKILELSFAVFPARSLESLDPLDA 583
                    .||..|.|:..:.:..|.::.:.|.|..|:: .|.:|.||...|..    :|.|  .
plant   284 --------SSFGNLNQLTRLYVDDNKLSGNFPNVLLNLT-GLSLLSLSNNKFTG----TLPP--N 333

  Fly   584 LLPLSQLIWLGLDNNNLKQVSNESFAQMRELSYINLSFNQLK-TLPRGLFQSDAHSHLVEIDLSY 647
            :..||.|:.....:|............:..|:||.|:.|||| ||..|...|.  |:|.|:|:..
plant   334 ITSLSNLMDFDASDNAFTGTFPSFLFTIPSLTYIRLNGNQLKGTLEFGNISSP--SNLYELDIGN 396

  Fly   648 NGLERLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSY-NRLVNISHGAFTVLPN 711
            |..          :|.:.:              :...|..|..||:|: |....:....|:.|.:
plant   397 NNF----------IGPIPS--------------SISKLVKLFRLDISHLNTQGPVDFSIFSHLKS 437

  Fly   712 LAALDLMH-NQLCSLSLKSFLYVSNTTTPLRLNVSHNHI-----ASFYDELSSYMYIYQLDISHN 770
            |..|::.| |....:.|..||  |.....|.|::|.||:     :|..|..|  ..|..|.:|..
plant   438 LLDLNISHLNTTTRIDLNYFL--SYFKRLLLLDLSGNHVSATNKSSVSDPPS--QLIQSLYLSGC 498

  Fly   771 HVTKSDSFTNLANTLRFLNLAHNQLGSLQSHAFGDLEFLEILNVAHNNLTSLRRRS--------- 826
            .:|:...|....:.|.||::::|::..........|..|..:|:::|.|...:|.|
plant   499 GITEFPEFVRTQHELGFLDISNNKIKGQVPDWLWRLPILYYVNLSNNTLIGFQRPSKPEPSLLYL 563

  Fly   827 --------------FQGLNSLQELDLSHNQLDQLQVEQFSNLRK-LRILRINSNRLR-ALPREVF 875
                          ..||.||..||||.|..:........:|:. |.:|.:..|.|. .||:::|
plant   564 LGSNNNFIGKIPSFICGLRSLNTLDLSDNNFNGSIPRCMGHLKSTLSVLNLRQNHLSGGLPKQIF 628

  Fly   876 MNTRLEFLDIAENQLSVWPVPAFTDIGFTLRSIQMSHNNLEYLDASMFINSQFLYDI-SLARNRI 939
              ..|..||:..||| |..:|.......||..:.:..|.         ||..|.:.: ||.:.::
plant   629 --EILRSLDVGHNQL-VGKLPRSLSFFSTLEVLNVESNR---------INDTFPFWLSSLPKLQV 681

  Fly   940 TILPDNTF------SFLNNLTNLDLSQNPLVTTNLREVFVHTPRLRKLSLHH---------MGLY 989
            .:|..|.|      :....|..:|:|.|....|...|.||....:..|..:.         .|||
plant   682 LVLRSNAFHGPIHEATFPELRIIDISHNRFNGTLPTEYFVKWSAMSSLGKNEDQSNEKYMGSGLY 746

  Fly   990 VLPPLK-------------LPLLSYLDVSGNYLQELSP--LGSLRHLRHVNVSHNKLTNASCAAE 1039
            ....:.             |.:.:.:|.|||..:...|  :|.|:.|..:::|:|..:.
plant   747 YQDSMVLMNKGVAMELVRILTIYTAVDFSGNRFEGEIPKSIGLLKELLVLSLSNNAFSG------ 805

  Fly  1040 HLPPS------VRVLDLAHNPLRRITLHDLASLRHLAELNILDVKVTNPQAFSKLRSLRKLHASS 1098
            |:|.|      :..||::.|.|......:|..|..||.:|.                       |
plant   806 HMPSSMGNLTALESLDVSKNKLTGEIPQELGDLSFLAYMNF-----------------------S 847

  Fly  1099 HANLGEIVARIPGLQQ-LRVHC--LEPNIGQQLFAKLANNTKIRLLELYGSNVQTIAPDVFTGLS 1160
            |..|..:|   ||.|| |..:|  .|.|:|                 |:||:::.:..|:.|..|
plant   848 HNQLAGLV---PGGQQFLTQNCSAFEDNLG-----------------LFGSSLEEVCRDIHTPAS 892

  Fly  1161 RSQRLQVKISHTRISDL----------PPGIFYAL 1185
            . |:.:...:.....||          .|||.:.|
plant   893 H-QQFETPETEEEDEDLISWIAAAIGFGPGIAFGL 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4168	NP_001285953.1	leucine-rich repeat	99..118	CDD:275380
		LRR_8	121..181	CDD:290566
		LRR_RI	122..350	CDD:238064	5/18 (28%)
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		LRR_8	265..322	CDD:290566
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..338	CDD:275380
		LRR_RI	315..546	CDD:238064	63/221 (29%)
		leucine-rich repeat	339..365	CDD:275380	9/33 (27%)
		LRR_8	365..424	CDD:290566	20/60 (33%)
		leucine-rich repeat	366..388	CDD:275380	6/22 (27%)
		leucine-rich repeat	389..412	CDD:275380	7/22 (32%)
		LRR_8	413..470	CDD:290566	23/60 (38%)
		leucine-rich repeat	414..436	CDD:275380	8/22 (36%)
		leucine-rich repeat	437..459	CDD:275380	8/24 (33%)
		leucine-rich repeat	460..483	CDD:275380	11/23 (48%)
		LRR_8	482..545	CDD:290566	11/63 (17%)
		leucine-rich repeat	484..510	CDD:275380	5/26 (19%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		leucine-rich repeat	535..589	CDD:275380	12/53 (23%)
		LRR_RI	588..891	CDD:238064	83/335 (25%)
		LRR_8	588..650	CDD:290566	20/62 (32%)
		leucine-rich repeat	590..613	CDD:275380	2/22 (9%)
		leucine-rich repeat	614..639	CDD:275380	12/25 (48%)
		LRR_8	638..698	CDD:290566	12/60 (20%)
		leucine-rich repeat	640..663	CDD:275380	4/22 (18%)
		leucine-rich repeat	664..687	CDD:275380	1/22 (5%)
		LRR_8	688..749	CDD:290566	19/62 (31%)
		leucine-rich repeat	688..711	CDD:275380	7/23 (30%)
		leucine-rich repeat	712..735	CDD:275380	7/23 (30%)
		leucine-rich repeat	740..783	CDD:275380	13/47 (28%)
		LRR_8	784..843	CDD:290566	20/81 (25%)
		leucine-rich repeat	785..808	CDD:275380	5/22 (23%)
		leucine-rich repeat	809..832	CDD:275380	8/45 (18%)
		LRR_RI	<827..1053	CDD:238064	64/264 (24%)
		LRR_8	832..890	CDD:290566	19/59 (32%)
		leucine-rich repeat	833..856	CDD:275380	7/22 (32%)
		leucine-rich repeat	857..879	CDD:275380	7/22 (32%)
		leucine-rich repeat	880..900	CDD:275380	8/19 (42%)
		LRR_8	904..963	CDD:290566	15/65 (23%)
		leucine-rich repeat	905..928	CDD:275380	4/22 (18%)
		leucine-rich repeat	929..952	CDD:275380	5/29 (17%)
		leucine-rich repeat	953..977	CDD:275380	8/23 (35%)
		leucine-rich repeat	978..1020	CDD:275380	12/65 (18%)
		LRR_8	1019..1074	CDD:290566	14/60 (23%)
		leucine-rich repeat	1045..1068	CDD:275380	6/22 (27%)
		leucine-rich repeat	1069..1090	CDD:275380	3/20 (15%)
		leucine-rich repeat	1091..1114	CDD:275380	6/22 (27%)
		leucine-rich repeat	1115..1161	CDD:275380	10/47 (21%)
		leucine-rich repeat	1162..1190	CDD:275380	7/34 (21%)
RLP53	NP_001332753.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I2000
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050