DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4168 and RLP40

DIOPT Version :9

Sequence 1:	NP_001285953.1	Gene:	CG4168 / 34889	FlyBaseID:	FBgn0028888	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_566757.2	Gene:	RLP40 / 822091	AraportID:	AT3G24982	Length:	915	Species:	Arabidopsis thaliana

Alignment Length:	844	Identity:	208/844 - (24%)
Similarity:	319/844 - (37%)	Gaps:	261/844 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 SDYFQQNYSDVHLRALNLEQNFVTQLPEAVFKATGIAHLVLAFNAISRVHPSAFEGLTETLEYLD 418
            |..||.:    |||:|.|..|..|.                  ::||    |.| |:...||.|.
plant   123 SSLFQFH----HLRSLLLPHNNFTS------------------SSIS----SKF-GMLNNLEVLS 160

  Fly   419 LERNR-LTTVPVALSSLHHLKYLYLTSNQISQLNNLPSFTEN---LRVLSLSGNNFSMI--PVLG 477
            |..:. |..||.:.|:|..|..|.|::|   .|....||..|   ||||.:|.|:||.|  |...
plant   161 LSSSGFLAQVPFSFSNLSMLSALVLSNN---DLTGSLSFARNLRKLRVLDVSYNHFSGILNPNSS 222

  Fly   478 LKNYTQLSYLNMGYNSITDIPEGIFAVDSWGSNLQTILLRNNKITHLHLGS----------FAGL 532
            |.....:.|||:.||:.|            .|:|.......||:..|.:.|          .:.|
plant   223 LFELHHIIYLNLRYNNFT------------SSSLPYEFGNLNKLEVLDVSSNSFFGQVPPTISNL 275

  Fly   533 EQIQEISLSFNDITIHHPLVFENVSRTLKILELSFAVFPARSLESLDPLDALLPLSQLIWLGLDN 597
            .|:.|:.|..|..|...||| :|::: |.||.| |....:.::.|     :|..:..|.:|.|..
plant   276 TQLTELYLPLNHFTGSLPLV-QNLTK-LSILHL-FGNHFSGTIPS-----SLFTMPFLSYLSLKG 332

  Fly   598 NNLK---QVSNESFAQMRELSYINLSFNQLKTLPRGLFQSDAHSHLV---EIDLSY-NGLERLEA 655
            |||.   :|.|.|.:...|..::..:..:.|.|       :..|.|:   |:|||: |....::.
plant   333 NNLNGSIEVPNSSSSSRLESLHLGENHFEGKIL-------EPISKLINLKELDLSFLNTSYPIDL 390

  Fly   656 QTFHSL---------GD----------------LQTLNLQ-------SNRLRTIARHAFHNLEFL 688
            ..|.||         ||                |:.|.|:       .|..:|:     ||||
plant   391 SLFSSLKSLLLLDLSGDWISKASLTLDSYIPSTLEVLRLEHCDISDFPNVFKTL-----HNLE-- 448

  Fly   689 RYLDLSYNRLVNISHGAFT----VLPNLAALDLMHNQLCSLSLKSFLYVSNTTTPLRLN------ 743
             |:.||.||:    .|.|.    .||.|:::.:..|.|......|.:.|:::...|.|:
plant   449 -YIALSNNRI----SGKFPEWLWSLPRLSSVFITDNLLTGFEGSSEVLVNSSVQILSLDTNSLEG 508

  Fly   744 ------VSHNHIASFYD--------ELSSYMYIYQLDISHNHVTKSDSFTN-----LANTLRFLN 789
                  :|.|:.::..:        .:.:...:..||:|:|      :||.     |:|.| :|.
plant   509 ALPHLPLSINYFSAIDNRFGGDIPLSICNRSSLDVLDLSYN------NFTGPIPPCLSNLL-YLK 566

  Fly   790 LAHNQL-GSLQSHAFGDLEFLEILNVAHNNLTSLRRRSFQGLNSLQELDLSHNQLDQLQVEQFSN 853
            |..|.| ||:....:.|.. |..|:|.:|.||....||....::||.|.:.||.:..........
plant   567 LRKNNLEGSIPDKYYEDTP-LRSLDVGYNRLTGKLPRSLINCSALQFLSVDHNGIKDTFPFSLKA 630

  Fly   854 LRKLRILRINSNRL---RALPREVFMN-TRLEFLDIAENQLS----------VWPVPAFT---DI 901
            |.||::|.::||:.   .:.|.|..:. ..|..|:||.|:|:          .|...:.|   |:
plant   631 LPKLQVLLLSSNKFYGPLSPPNEGPLGFPELRILEIAGNKLTGSFLSSDFFVNWKASSHTMNEDL 695

  Fly   902 GFTL---------------RSIQMSHNNLEYLDASMFINSQFLYDISLARNRITILPDNTFSFLN 951
            |..:               .:|.:.:..|.....::..:|.   .|..:.||:......:...|.
plant   696 GLYMVYGKVIFGNYHLTYYETIDLRYKGLSMEQRNVLTSSA---TIDFSGNRLEGEIPESIGLLK 757

  Fly   952 NLTNLDLSQN------PLVTTNLREVFVHTPRLRKLSLHHMGLYVLPPLKLPLLSYLDVSGNYLQ 1010
            .|..|:||.|      ||...||::                            :..||:|.|.|.
plant   758 ALIALNLSNNAFTGHIPLSFANLKK----------------------------MESLDLSSNQLS 794

  Fly  1011 ELSPLG--SLRHLRHVNVSHNKLT-------------------NA---------SCAAEHLPPS 1044
            ...|.|  :|..|.:||||||:|.                   ||         ||...:.||:
plant   795 GTIPNGLRTLSFLAYVNVSHNQLIGEIPQGTQITGQPKSSFEGNAGLCGFPLQESCFGTNTPPA 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4168	NP_001285953.1	leucine-rich repeat	99..118	CDD:275380
		LRR_8	121..181	CDD:290566
		LRR_RI	122..350	CDD:238064
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		LRR_8	265..322	CDD:290566
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..338	CDD:275380
		LRR_RI	315..546	CDD:238064	60/207 (29%)
		leucine-rich repeat	339..365	CDD:275380	3/10 (30%)
		LRR_8	365..424	CDD:290566	16/59 (27%)
		leucine-rich repeat	366..388	CDD:275380	6/21 (29%)
		leucine-rich repeat	389..412	CDD:275380	5/22 (23%)
		LRR_8	413..470	CDD:290566	23/60 (38%)
		leucine-rich repeat	414..436	CDD:275380	9/22 (41%)
		leucine-rich repeat	437..459	CDD:275380	7/21 (33%)
		leucine-rich repeat	460..483	CDD:275380	11/24 (46%)
		LRR_8	482..545	CDD:290566	17/72 (24%)
		leucine-rich repeat	484..510	CDD:275380	6/25 (24%)
		leucine-rich repeat	511..534	CDD:275380	6/32 (19%)
		leucine-rich repeat	535..589	CDD:275380	15/53 (28%)
		LRR_RI	588..891	CDD:238064	93/375 (25%)
		LRR_8	588..650	CDD:290566	19/68 (28%)
		leucine-rich repeat	590..613	CDD:275380	9/25 (36%)
		leucine-rich repeat	614..639	CDD:275380	2/24 (8%)
		LRR_8	638..698	CDD:290566	25/95 (26%)
		leucine-rich repeat	640..663	CDD:275380	9/35 (26%)
		leucine-rich repeat	664..687	CDD:275380	8/29 (28%)
		LRR_8	688..749	CDD:290566	18/76 (24%)
		leucine-rich repeat	688..711	CDD:275380	8/26 (31%)
		leucine-rich repeat	712..735	CDD:275380	5/22 (23%)
		leucine-rich repeat	740..783	CDD:275380	11/67 (16%)
		LRR_8	784..843	CDD:290566	21/59 (36%)
		leucine-rich repeat	785..808	CDD:275380	8/23 (35%)
		leucine-rich repeat	809..832	CDD:275380	8/22 (36%)
		LRR_RI	<827..1053	CDD:238064	61/286 (21%)
		LRR_8	832..890	CDD:290566	18/61 (30%)
		leucine-rich repeat	833..856	CDD:275380	6/22 (27%)
		leucine-rich repeat	857..879	CDD:275380	6/25 (24%)
		leucine-rich repeat	880..900	CDD:275380	8/32 (25%)
		LRR_8	904..963	CDD:290566	12/79 (15%)
		leucine-rich repeat	905..928	CDD:275380	3/37 (8%)
		leucine-rich repeat	929..952	CDD:275380	4/22 (18%)
		leucine-rich repeat	953..977	CDD:275380	9/29 (31%)
		leucine-rich repeat	978..1020	CDD:275380	8/43 (19%)
		LRR_8	1019..1074	CDD:290566	14/54 (26%)
		leucine-rich repeat	1045..1068	CDD:275380	208/844 (25%)
		leucine-rich repeat	1069..1090	CDD:275380
		leucine-rich repeat	1091..1114	CDD:275380
		leucine-rich repeat	1115..1161	CDD:275380
		leucine-rich repeat	1162..1190	CDD:275380
RLP40	NP_566757.2	LRR_RI	97..>263	CDD:238064	55/181 (30%)
		LRR_8	130..190	CDD:290566	25/85 (29%)
		leucine-rich repeat	131..155	CDD:275380	11/46 (24%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..202	CDD:275380	8/24 (33%)
		LRR_8	201..264	CDD:290566	23/74 (31%)
		leucine-rich repeat	203..228	CDD:275380	11/24 (46%)
		leucine-rich repeat	229..253	CDD:275380	8/35 (23%)
		leucine-rich repeat	254..277	CDD:275380	3/22 (14%)
		leucine-rich repeat	278..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..324	CDD:275380	7/28 (25%)
		leucine-rich repeat	325..349	CDD:275380	9/23 (39%)
		leucine-rich repeat	350..371	CDD:275380	4/27 (15%)
		LRR_8	422..481	CDD:290566	20/70 (29%)
		leucine-rich repeat	424..446	CDD:275380	5/26 (19%)
		leucine-rich repeat	447..468	CDD:275380	9/27 (33%)
		leucine-rich repeat	471..495	CDD:275380	5/23 (22%)
		leucine-rich repeat	517..540	CDD:275380	1/22 (5%)
		leucine-rich repeat	541..585	CDD:275380	16/50 (32%)
		LRR_8	560..620	CDD:290566	22/61 (36%)
		leucine-rich repeat	563..583	CDD:275380	7/20 (35%)
		leucine-rich repeat	586..609	CDD:275380	8/22 (36%)
		leucine-rich repeat	610..633	CDD:275380	6/22 (27%)
		leucine-rich repeat	634..660	CDD:275380	6/25 (24%)
		leucine-rich repeat	735..758	CDD:275380	5/25 (20%)
		leucine-rich repeat	759..782	CDD:275380	9/22 (41%)
		LRR_8	762..817	CDD:290566	23/82 (28%)
		leucine-rich repeat	783..806	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I2000
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050