DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4168 and LRRC4C

DIOPT Version :9

Sequence 1:NP_001285953.1 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster
Sequence 2:NP_001245348.1 Gene:LRRC4C / 57689 HGNCID:29317 Length:640 Species:Homo sapiens


Alignment Length:429 Identity:109/429 - (25%)
Similarity:175/429 - (40%) Gaps:97/429 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   444 SNQISQ-------LNNLP-SFTENLRVLSLSGNNFSMIPVLGLKNYTQLSYLNMGYNSITDIPEG 500
            |||.|:       |..:| ..:.|.|:|:|..|...:|.|...|:...|..|.:..|.|..|..|
Human    54 SNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIG 118

  Fly   501 IFAVDSWGSNLQTILLRNNKITHLHLGSFAGLEQIQEISLSFNDITIHHPLVFENVSRTLKILEL 565
            .|   :..:||.|:.|.:|::|.:..|:|..|.:::|:.|..|.|        |::.        
Human   119 AF---NGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPI--------ESIP-------- 164

  Fly   566 SFAVFPARSLESLDPLDALLPLSQLIWLGLDNNNLKQVSNESFAQMRELSYINLSFNQLKTLPR- 629
            |:|.....||..||       |.:|       ..|..:|..:|..:..|.|:||:...|:.:|. 
Human   165 SYAFNRIPSLRRLD-------LGEL-------KRLSYISEGAFEGLSNLRYLNLAMCNLREIPNL 215

  Fly   630 -GLFQSDAHSHLVEIDLSYNGLERLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDL 693
             .|.:.|      |:|||.|.|..:...:|..|..||.|.:..::::.|.|:||.||:.|..::|
Human   216 TPLIKLD------ELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINL 274

  Fly   694 SYNRLVNISHGAFTVLPNLAALDLMHNQL---CSLSLKSF----LYVSNTTTPLRLNVSHNHIAS 751
            ::|.|..:.|..||.|.:|..:.|.||..   |.:...|:    :..|||....|.|...|....
Human   275 AHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGR 339

  Fly   752 FYDEL-SSYMYIY---------QLDISHNHVTK-----SDSFTNLA------------------- 782
            :..|| .:|...|         .|:::.....:     |.|.|:::                   
Human   340 YIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIA 404

  Fly   783 ----NTLRFLNLAHNQLG---SLQSHAFGDLEFLEILNV 814
                .||.|.|:.....|   .:.|::.|:......|||
Human   405 VLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNV 443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4168NP_001285953.1 leucine-rich repeat 99..118 CDD:275380
LRR_8 121..181 CDD:290566
LRR_RI 122..350 CDD:238064
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
LRR_8 265..322 CDD:290566
leucine-rich repeat 266..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..338 CDD:275380
LRR_RI 315..546 CDD:238064 33/109 (30%)
leucine-rich repeat 339..365 CDD:275380
LRR_8 365..424 CDD:290566
leucine-rich repeat 366..388 CDD:275380
leucine-rich repeat 389..412 CDD:275380
LRR_8 413..470 CDD:290566 11/33 (33%)
leucine-rich repeat 414..436 CDD:275380
leucine-rich repeat 437..459 CDD:275380 6/22 (27%)
leucine-rich repeat 460..483 CDD:275380 7/22 (32%)
LRR_8 482..545 CDD:290566 19/62 (31%)
leucine-rich repeat 484..510 CDD:275380 7/25 (28%)
leucine-rich repeat 511..534 CDD:275380 8/22 (36%)
leucine-rich repeat 535..589 CDD:275380 12/53 (23%)
LRR_RI 588..891 CDD:238064 67/277 (24%)
LRR_8 588..650 CDD:290566 17/63 (27%)
leucine-rich repeat 590..613 CDD:275380 4/22 (18%)
leucine-rich repeat 614..639 CDD:275380 8/26 (31%)
LRR_8 638..698 CDD:290566 20/59 (34%)
leucine-rich repeat 640..663 CDD:275380 8/22 (36%)
leucine-rich repeat 664..687 CDD:275380 9/22 (41%)
LRR_8 688..749 CDD:290566 20/67 (30%)
leucine-rich repeat 688..711 CDD:275380 8/22 (36%)
leucine-rich repeat 712..735 CDD:275380 6/29 (21%)
leucine-rich repeat 740..783 CDD:275380 11/80 (14%)
LRR_8 784..843 CDD:290566 10/34 (29%)
leucine-rich repeat 785..808 CDD:275380 6/25 (24%)
leucine-rich repeat 809..832 CDD:275380 3/6 (50%)
LRR_RI <827..1053 CDD:238064
LRR_8 832..890 CDD:290566
leucine-rich repeat 833..856 CDD:275380
leucine-rich repeat 857..879 CDD:275380
leucine-rich repeat 880..900 CDD:275380
LRR_8 904..963 CDD:290566
leucine-rich repeat 905..928 CDD:275380
leucine-rich repeat 929..952 CDD:275380
leucine-rich repeat 953..977 CDD:275380
leucine-rich repeat 978..1020 CDD:275380
LRR_8 1019..1074 CDD:290566
leucine-rich repeat 1045..1068 CDD:275380
leucine-rich repeat 1069..1090 CDD:275380
leucine-rich repeat 1091..1114 CDD:275380
leucine-rich repeat 1115..1161 CDD:275380
leucine-rich repeat 1162..1190 CDD:275380
LRRC4CNP_001245348.1 LRRNT 47..80 CDD:214470 7/25 (28%)
PPP1R42 65..235 CDD:411060 56/208 (27%)
LRR 1 77..98 7/20 (35%)
leucine-rich repeat 78..101 CDD:275380 7/22 (32%)
LRR 2 101..122 7/23 (30%)
leucine-rich repeat 102..125 CDD:275380 7/25 (28%)
LRR 3 125..146 8/20 (40%)
leucine-rich repeat 126..149 CDD:275380 8/22 (36%)
LRR 4 149..170 7/36 (19%)
leucine-rich repeat 150..173 CDD:275380 7/38 (18%)
LRR 5 173..195 9/35 (26%)
leucine-rich repeat 174..198 CDD:275380 8/37 (22%)
LRR 6 198..219 6/20 (30%)
leucine-rich repeat 199..220 CDD:275380 7/20 (35%)
LRR_8 220..279 CDD:404697 21/64 (33%)
LRR 7 220..241 8/26 (31%)
leucine-rich repeat 221..244 CDD:275380 9/28 (32%)
LRR 8 244..265 7/20 (35%)
leucine-rich repeat 245..268 CDD:275380 9/22 (41%)
LRR_8 267..>301 CDD:404697 10/33 (30%)
LRR 9 268..289 6/20 (30%)
leucine-rich repeat 269..290 CDD:275380 7/20 (35%)
LRRCT 301..>339 CDD:214507 9/37 (24%)
IG 360..443 CDD:214652 12/82 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 463..483
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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