DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4168 and si:dkey-90m5.4

DIOPT Version :9

Sequence 1:	NP_001285953.1	Gene:	CG4168 / 34889	FlyBaseID:	FBgn0028888	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_001038237.1	Gene:	si:dkey-90m5.4 / 553466	ZFINID:	ZDB-GENE-041014-250	Length:	327	Species:	Danio rerio

Alignment Length:	293	Identity:	83/293 - (28%)
Similarity:	126/293 - (43%)	Gaps:	65/293 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 HVAGNYLPRSLVTMDLSSNLLTVFPQQLFEQLPELRIVSLRDNLIRSVQWKELQVRPLRMHLERL 342
            |..|:.||.|..::.:....|||...:      .||.|.|                     ||.|
Zfish    47 HFPGDGLPPSTTSLTIQFTNLTVLTSE------HLRAVPL---------------------LEEL 84

  Fly   343 DLGQNCIENLESDYFQQNYSDV-HLRALNLEQNFVTQLPEAVFKATGIAHLVLAFNAISRVHPSA 406
            .|..|.:.:|.:|..:    |: :|..::|..|.:.:|||.||:...:.:|||..|.||.:||..
Zfish    85 HLPGNKLSSLPADILK----DLKYLHTIDLTDNELRELPEYVFRHAPLLNLVLKDNRISNIHPDW 145

  Fly   407 FEGLTETLEYLDLERNRLTTVPVA-LSSLHHLKYLYLTSNQISQLNNLPSFTENLRVLSLSGNNF 470
            |.. ...|.:|||..|:|...|:| |.:|.|||.|:|:.|:|.:|
Zfish   146 FPN-NSNLTWLDLSGNQLMKFPMAQLQNLRHLKVLHLSQNKIEEL-------------------- 189

  Fly   471 SMIPVLGLKNYTQLSYLNMGYNSITDIPEGIFAVDSWGSNLQTILLRNNKITHLHLGSFAGLEQI 535
               ||..|..:|.|..|.:..|.|..:....|   |..:||..|.|:.|:|..|....|..|:::
Zfish   190 ---PVGCLDAHTALERLYLDQNKIQTLDVKAF---SGSTNLTHIFLQKNRIDSLPPTVFQELKRL 248

  Fly   536 QEISLSFNDITIHHPLVFE-NVSRTLKILELSF 567
            :.:.||.|.:....|.:.: |.|    .:||:|
Zfish   249 EYVDLSDNRLQFLSPGILDINTS----WVELTF 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4168	NP_001285953.1	leucine-rich repeat	99..118	CDD:275380
		LRR_8	121..181	CDD:290566
		LRR_RI	122..350	CDD:238064	17/71 (24%)
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		LRR_8	265..322	CDD:290566	12/43 (28%)
		leucine-rich repeat	266..287	CDD:275380	4/8 (50%)
		leucine-rich repeat	288..311	CDD:275380	3/22 (14%)
		leucine-rich repeat	312..338	CDD:275380	4/25 (16%)
		LRR_RI	315..546	CDD:238064	67/232 (29%)
		leucine-rich repeat	339..365	CDD:275380	8/26 (31%)
		LRR_8	365..424	CDD:290566	22/58 (38%)
		leucine-rich repeat	366..388	CDD:275380	8/21 (38%)
		leucine-rich repeat	389..412	CDD:275380	9/22 (41%)
		LRR_8	413..470	CDD:290566	18/57 (32%)
		leucine-rich repeat	414..436	CDD:275380	10/22 (45%)
		leucine-rich repeat	437..459	CDD:275380	7/21 (33%)
		leucine-rich repeat	460..483	CDD:275380	3/22 (14%)
		LRR_8	482..545	CDD:290566	19/62 (31%)
		leucine-rich repeat	484..510	CDD:275380	6/25 (24%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		leucine-rich repeat	535..589	CDD:275380	9/34 (26%)
		LRR_RI	588..891	CDD:238064
		LRR_8	588..650	CDD:290566
		leucine-rich repeat	590..613	CDD:275380
		leucine-rich repeat	614..639	CDD:275380
		LRR_8	638..698	CDD:290566
		leucine-rich repeat	640..663	CDD:275380
		leucine-rich repeat	664..687	CDD:275380
		LRR_8	688..749	CDD:290566
		leucine-rich repeat	688..711	CDD:275380
		leucine-rich repeat	712..735	CDD:275380
		leucine-rich repeat	740..783	CDD:275380
		LRR_8	784..843	CDD:290566
		leucine-rich repeat	785..808	CDD:275380
		leucine-rich repeat	809..832	CDD:275380
		LRR_RI	<827..1053	CDD:238064
		LRR_8	832..890	CDD:290566
		leucine-rich repeat	833..856	CDD:275380
		leucine-rich repeat	857..879	CDD:275380
		leucine-rich repeat	880..900	CDD:275380
		LRR_8	904..963	CDD:290566
		leucine-rich repeat	905..928	CDD:275380
		leucine-rich repeat	929..952	CDD:275380
		leucine-rich repeat	953..977	CDD:275380
		leucine-rich repeat	978..1020	CDD:275380
		LRR_8	1019..1074	CDD:290566
		leucine-rich repeat	1045..1068	CDD:275380
		leucine-rich repeat	1069..1090	CDD:275380
		leucine-rich repeat	1091..1114	CDD:275380
		leucine-rich repeat	1115..1161	CDD:275380
		leucine-rich repeat	1162..1190	CDD:275380
si:dkey-90m5.4	NP_001038237.1	LRR_8	55..115	CDD:404697	19/90 (21%)
		leucine-rich repeat	57..80	CDD:275380	6/28 (21%)
		leucine-rich repeat	81..104	CDD:275380	8/26 (31%)
		PPP1R42	102..279	CDD:411060	63/207 (30%)
		leucine-rich repeat	105..126	CDD:275380	8/20 (40%)
		leucine-rich repeat	128..151	CDD:275380	9/23 (39%)
		leucine-rich repeat	152..175	CDD:275380	10/22 (45%)
		leucine-rich repeat	176..199	CDD:275380	10/45 (22%)
		leucine-rich repeat	200..223	CDD:275380	6/25 (24%)
		leucine-rich repeat	224..247	CDD:275380	8/22 (36%)
		leucine-rich repeat	248..271	CDD:275380	5/22 (23%)
		TPKR_C2	278..319	CDD:417692	83/293 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100