back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4168 and lbk

DIOPT Version :9

Sequence 1:	NP_001285953.1	Gene:	CG4168 / 34889	FlyBaseID:	FBgn0028888	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_611091.2	Gene:	lbk / 36788	FlyBaseID:	FBgn0034083	Length:	1252	Species:	Drosophila melanogaster

Alignment Length:	1211	Identity:	255/1211 - (21%)
Similarity:	424/1211 - (35%)	Gaps:	367/1211 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 HITTLDGNWDAQHDTLR-----SLHLSDNDITEVAPGGGSIEVVS----------QNDNSSQPSS 229
            |::.:.|    :|.|..     |:.:|:..|.::...|....::|          .|:|||..::
  Fly     2 HVSAIKG----RHPTRESNDDSSMVISNYRICDIKTSGNGKYLMSWSRRRRRNNNNNNNSSSNNN 62

  Fly   230 LAAVQTR------LETSNSI-----------------------YPPSPSS-------GDRTTGGR 258
            .||.::|      ..|:|..                       ...||||       |..:|||.
  Fly    63 NAASESRSNDNCNYSTTNDFNKINKLLLITYMLLITAATICQSAAQSPSSSNGNGVGGSGSTGGS 127

  Fly   259 PFEQL-------------QKLLWLDLSNNRIYHVAGNYLPRSLVTMDLSSNLLTVFPQQLFEQLP 310
            |...|             |:.|:..|:.|.    .|:..|||     ...|......:|.|..|.
  Fly   128 PLSALLKSGGASYNQQLPQQQLFAMLTRNG----GGSSGPRS-----SGGNRGYTSARQHFMALS 183

  Fly   311 ELRIVSLRDNLIRSVQWKELQVRPLRMHLERLDLGQNCIENLESDYFQQNYSDVHLRALNLEQN- 374
            |       |.....|..:::......:.......|   ::...|.      |.:.:::.:||.|
  Fly   184 E-------DYSDADVDEEDMAALHYPLSASHPPAG---VQGSSSS------SGISIQSGSLETNG 232

  Fly   375 FVT----QLPEAVFKATGIAHLVLAFNAISRVHPSAFEGLTETLEYLDLERNRLTTVPVALSSLH 435
            ||.    |...|.......|....|.|..:...|...:.|.   ...|.::..|..|||
  Fly   233 FVADDGGQYEHAQKALEAAAAAAKASNKYNIDCPKDCKCLN---VLFDCDKLHLERVPV------ 288

  Fly   436 HLKYLYLTSNQISQLNNLPSFTENLRVLSLSGNNFSMIPVLGLKNYTQLSYLNMGYNSITDIPEG 500
                             |||:.:.|.   |:.|..:...||.::|...|:.:::..|.:..||:.
  Fly   289 -----------------LPSYVQTLH---LANNKLNDTTVLEIRNLLNLTKVSLKRNLLEVIPKF 333

  Fly   501 IFAVDSWGSNLQTILLRNNKITHLHLGSFAGLEQIQEISLSFNDITIHHPLVFENVSRTLKILEL 565
            |..     |.|:.::|.||.||.:...|.|.|..::.:.||.|               .|..:||
  Fly   334 IGL-----SGLKHLVLANNHITSISSESLAALPLLRTLDLSRN---------------KLHTIEL 378

  Fly   566 SFAVFPARSLESLDPLDALLPLSQLIWLGLDNNNLKQVSNESFAQMRELSYINLSFNQLKTLPRG 630
            :  .||..              :.|:.|.|..|.:..|:..|||.:..|:.:.||.|:|.|||..
  Fly   379 N--SFPKS--------------NNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIR 427

  Fly   631 LFQSDAHSHLVEIDLSYNGLERLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSY 695
            :|::  .:.|.::.|::|.|| :...||..|..::.|.|:||::|.
  Fly   428 VFKN--LNQLKKLALNFNQLE-INWSTFRGLESMKNLQLKSNKIRA------------------- 470

  Fly   696 NRLVNISHGAFTVLPNLAALDLMHNQLCSLSLKSFLYVSNTTTPLRLNVSHNHIASFYDELSSYM 760
                 :..|.|.|:..:..:||..||:.|||.:...   |.|....||:|.|.|:..  |:.::.
  Fly   471 -----LQDGVFYVMHKIETIDLAMNQISSLSRQGLF---NLTKLRHLNLSFNAISRI--EVDTWE 525

  Fly   761 Y---IYQLDISHNHVTK-SDSFTNLANTLRFLNLAHNQLGSLQSHAFGDLEFLEILNVAHNNLTS 821
            :   :..||:|:|.:.: .....:..:.|:.||||||:|..||.:.|..::.||.||:..|.|:.
  Fly   526 FTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCVKNLEELNLRRNRLSW 590

  Fly   822 L-----RRRSFQGLNSLQELDLSHNQLDQLQVEQFSNLRKLRILRINSNRLRALPREVFMN---- 877
            :     ....|:||..|:.|||..|.|.|:..:..|.|..|.||.:.||.|.::....|.:
  Fly   591 IIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGSNALASIQVNAFEHMLRL 655

  Fly   878 TRLEFLD---IAENQL---SVWPVPAFTDIGFTLRSIQMSHNNLEY----LDASM-FINSQFLYD 931
            .:|.|..   |.:..|   ..|....|..        |..|....|    ||..: .::|..|..
  Fly   656 NKLVFKSLNFICDCDLVWFQQWLKNRFPQ--------QAEHAVCGYPEHLLDRHLKSLSSSELVC 712

  Fly   932 ISLARNRITILPDNTFSFLNNLTNLDLSQNPLVTTNLREVFVHTPRLRKLSLHHMGLYVLPPLKL 996
            :...:.|:...||:..:.  |..|:.|           |....:|....|:       ....||:
  Fly   713 VDSPKPRVEQEPDDMLAV--NAANITL-----------ECIASSPTAASLA-------AADELKI 757

  Fly   997 PLLSYLDVSGNYLQELSPLGSLRHLRHVNVSHNKLTNASCAAEHLPPSVRVLDLAHNPLRRITLH 1061
                                   ..||.|             :|:.             .|..:|
  Fly   758 -----------------------KWRHDN-------------QHVQ-------------ERPAVH 773

  Fly  1062 DLAS----LRHLAELNILDV----KVTN-------------PQAFSKLRSLR-KLHASSHANLGE 1104
            |.||    :||....|...:    ::||             ..||....:.: |:....|....:
  Fly   774 DGASTETQIRHDLSTNQTSIYGYLRLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQ 838

  Fly  1105 IVAR--IPGLQQLRVHCL-----EPNIGQQLF--AKLANNTKIRLLELYGSNVQTIA------PD 1154
            :.:.  :...:..|:.|.     .|.|..|.|  ::....|:.||..:...|...|.      ..
  Fly   839 VPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQVIREENAFLITNAKPSDSG 903

  Fly  1155 VFTGLSRSQRLQVKISHTRISDLPPGIFYALREVPHLSIDISHNRINALAADSFYPNKSYWDAVG 1219
            ::|..:.|...::|::.|.:          :.:.|..||.:.|..:                .||
  Fly   904 IYTCTALSAAGEIKVNATLV----------VNDKPQPSIPLVHQEV----------------VVG 942

  Fly  1220 TRSIMGGLI-TSHNPLECECGLVWFGHWLRRWLRESAQIKV 1259
            ...::..|. |::...|.|       |..|.|.:|:..|.:
  Fly   943 RTCVLQCLSETANADFELE-------HPHREWFKENKPIHI 976

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.