DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4168 and IGFALS

DIOPT Version :9

Sequence 1:NP_001285953.1 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster
Sequence 2:NP_001139478.1 Gene:IGFALS / 3483 HGNCID:5468 Length:643 Species:Homo sapiens


Alignment Length:626 Identity:185/626 - (29%)
Similarity:267/626 - (42%) Gaps:108/626 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   484 LSYLNMGYNSITDIPEG--------------IFAVDSWGSNLQTILLRNNKITHLHLGSFAGLEQ 534
            ||::.:|..|:.....|              :.:.|.....| ::...:..:|.|..|...|   
Human    53 LSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADEL-SVFCSSRNLTRLPDGVPGG--- 113

  Fly   535 IQEISLSFNDITIHHPLVFENVSRTLKILELSFAVFPARSLESLDPLDALLPLSQLIWLGLDNNN 599
            .|.:.|..|:::...|..|:|:|      .|.|.......|.||:| .|||.|..|..|.|:.|.
Human   114 TQALWLDGNNLSSVPPAAFQNLS------SLGFLNLQGGQLGSLEP-QALLGLENLCHLHLERNQ 171

  Fly   600 LKQVSNESFAQMRELSYINLSFNQLKTLPRGLFQSDAHSHLVEIDLSYNGLERLEAQTFHSLGDL 664
            |:.::..:||....|:.:.||.|:|..|..|||  :....|.:::|.:|.|..|....|..||.|
Human   172 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLF--EGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 234

  Fly   665 QTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISHGAFTVLPNLAALDLMHNQLCSLSLKS 729
            :.|.|..|||..:....|..|..||.||||.|.|..|....|..||.|..|.|..|.:.:::..:
Human   235 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGA 299

  Fly   730 FLYVSNTTTPLR-LNVSHNHIASFYDELSSYMYIYQLDISHNHVTKSDSFTNLANTLRFLNLAHN 793
            ||.:.    .|| |::|||.:|...:                     |:|..|.. ||.|.|:||
Human   300 FLGLK----ALRWLDLSHNRVAGLLE---------------------DTFPGLLG-LRVLRLSHN 338

  Fly   794 QLGSLQSHAFGDLEFLEILNVAHNNLTSLRRRSFQGLNSLQELDLSHNQLDQLQVEQFSNLRKLR 858
            .:.||:...|.||.|||.|.:.||.:..|..|||:||..|:.|.|.||||.:::...|..|..:.
Human   339 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 403

  Fly   859 ILRINSNRLRALPREVFMNT-RLEFLDIAENQLSVWPVPAFTDIGFTLRSIQMSHNNLEYLDASM 922
            ::.::.|.||.||.:||... :|..|.:..:.|.......||.:. .||.:.:..|.|..::...
Human   404 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLS-GLRRLFLKDNGLVGIEEQS 467

  Fly   923 FINSQFLYDISLARNRITILPDNTFSFLNNLTNLDLSQNPLVTTNLREVFVHTPRLRKLSLHHMG 987
            ......|.::.|..|::|.||...|..|..|..|.||:|               ||.:|....:|
Human   468 LWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN---------------RLAELPADALG 517

  Fly   988 LYVLPPLKLPLLSYLDVSGNYLQE-----LSPLGSLRHLRHVNVSHNKLTNASCAAEHLPPSVRV 1047
                 ||:...  :||||.|.|:.     |:|||.||:|...|.|....|..       ||.:..
Human   518 -----PLQRAF--WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-------PPGLER 568

  Fly  1048 LDLAHNPLRRITLHD----LASLRHLAELNILDVKVTNPQA 1084
            |.|..||      .|    |.:||        |..:.||.|
Human   569 LWLEGNP------WDCGCPLKALR--------DFALQNPSA 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4168NP_001285953.1 leucine-rich repeat 99..118 CDD:275380
LRR_8 121..181 CDD:290566
LRR_RI 122..350 CDD:238064
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
LRR_8 265..322 CDD:290566
leucine-rich repeat 266..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..338 CDD:275380
LRR_RI 315..546 CDD:238064 14/75 (19%)
leucine-rich repeat 339..365 CDD:275380
LRR_8 365..424 CDD:290566
leucine-rich repeat 366..388 CDD:275380
leucine-rich repeat 389..412 CDD:275380
LRR_8 413..470 CDD:290566
leucine-rich repeat 414..436 CDD:275380
leucine-rich repeat 437..459 CDD:275380
leucine-rich repeat 460..483 CDD:275380
LRR_8 482..545 CDD:290566 14/74 (19%)
leucine-rich repeat 484..510 CDD:275380 6/39 (15%)
leucine-rich repeat 511..534 CDD:275380 5/22 (23%)
leucine-rich repeat 535..589 CDD:275380 17/53 (32%)
LRR_RI 588..891 CDD:238064 101/304 (33%)
LRR_8 588..650 CDD:290566 19/61 (31%)
leucine-rich repeat 590..613 CDD:275380 7/22 (32%)
leucine-rich repeat 614..639 CDD:275380 9/24 (38%)
LRR_8 638..698 CDD:290566 23/59 (39%)
leucine-rich repeat 640..663 CDD:275380 7/22 (32%)
leucine-rich repeat 664..687 CDD:275380 8/22 (36%)
LRR_8 688..749 CDD:290566 24/61 (39%)
leucine-rich repeat 688..711 CDD:275380 11/22 (50%)
leucine-rich repeat 712..735 CDD:275380 6/22 (27%)
leucine-rich repeat 740..783 CDD:275380 10/43 (23%)
LRR_8 784..843 CDD:290566 28/58 (48%)
leucine-rich repeat 785..808 CDD:275380 11/22 (50%)
leucine-rich repeat 809..832 CDD:275380 11/22 (50%)
LRR_RI <827..1053 CDD:238064 67/231 (29%)
LRR_8 832..890 CDD:290566 18/58 (31%)
leucine-rich repeat 833..856 CDD:275380 9/22 (41%)
leucine-rich repeat 857..879 CDD:275380 7/22 (32%)
leucine-rich repeat 880..900 CDD:275380 4/19 (21%)
LRR_8 904..963 CDD:290566 17/58 (29%)
leucine-rich repeat 905..928 CDD:275380 4/22 (18%)
leucine-rich repeat 929..952 CDD:275380 8/22 (36%)
leucine-rich repeat 953..977 CDD:275380 5/23 (22%)
leucine-rich repeat 978..1020 CDD:275380 16/46 (35%)
LRR_8 1019..1074 CDD:290566 15/58 (26%)
leucine-rich repeat 1045..1068 CDD:275380 7/26 (27%)
leucine-rich repeat 1069..1090 CDD:275380 4/16 (25%)
leucine-rich repeat 1091..1114 CDD:275380
leucine-rich repeat 1115..1161 CDD:275380
leucine-rich repeat 1162..1190 CDD:275380
IGFALSNP_001139478.1 LRRNT 78..116 CDD:214470 6/41 (15%)
leucine-rich repeat 95..113 CDD:275380 3/17 (18%)
leucine-rich repeat 114..137 CDD:275380 7/28 (25%)
leucine-rich repeat 138..161 CDD:275380 10/23 (43%)
LRR_8 141..196 CDD:290566 19/55 (35%)
leucine-rich repeat 162..185 CDD:275380 7/22 (32%)
LRR_8 184..244 CDD:290566 21/61 (34%)
leucine-rich repeat 186..209 CDD:275380 9/24 (38%)
leucine-rich repeat 210..233 CDD:275380 7/22 (32%)
leucine-rich repeat 234..257 CDD:275380 8/22 (36%)
LRR_8 257..316 CDD:290566 24/62 (39%)
leucine-rich repeat 258..281 CDD:275380 11/22 (50%)
leucine-rich repeat 282..305 CDD:275380 6/26 (23%)
leucine-rich repeat 306..324 CDD:275380 8/38 (21%)
LRR_8 336..388 CDD:290566 24/51 (47%)
leucine-rich repeat 354..377 CDD:275380 11/22 (50%)
LRR_8 377..433 CDD:290566 18/55 (33%)
leucine-rich repeat 378..401 CDD:275380 9/22 (41%)
leucine-rich repeat 402..423 CDD:275380 7/20 (35%)
LRR_8 425..484 CDD:290566 12/59 (20%)
leucine-rich repeat 426..447 CDD:275380 5/20 (25%)
leucine-rich repeat 450..473 CDD:275380 4/22 (18%)
leucine-rich repeat 474..497 CDD:275380 8/22 (36%)
LRR_8 476..532 CDD:290566 23/77 (30%)
leucine-rich repeat 498..519 CDD:275380 9/40 (23%)
leucine-rich repeat 522..543 CDD:275380 7/22 (32%)
LRR_8 524..575 CDD:290566 20/57 (35%)
leucine-rich repeat 546..565 CDD:275380 7/25 (28%)
TPKR_C2 574..618 CDD:301599 10/36 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D299282at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4879
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.950

Return to query results.
Submit another query.