DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4168 and Lrig1

DIOPT Version :9

Sequence 1:NP_001285953.1 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster
Sequence 2:XP_232237.6 Gene:Lrig1 / 312574 RGDID:1306788 Length:1096 Species:Rattus norvegicus


Alignment Length:646 Identity:152/646 - (23%)
Similarity:252/646 - (39%) Gaps:191/646 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   392 LVLAFNAISRVHPSAFEGLTETLEYLDLERNRLTTVPVALSSLHHLKYLYLTSNQISQLNNLPSF 456
            |.|::|.:|.:.|:|||.|| .|:.:.|..|.||.||...::..|:..|:|..|           
  Rat    78 LNLSYNRLSEIDPAAFEDLT-NLQEVYLNSNELTAVPSLGAASMHVVSLFLQHN----------- 130

  Fly   457 TENLRVLSLSGNNFSMIPVLGLKNYTQLSYLNMGYNSITDIPEGIFAVDSWGSNLQTILLRNNKI 521
                ::||:.|:.        ||:|..|..|::..|:||:|....|.                  
  Rat   131 ----KILSVDGSQ--------LKSYLSLEVLDLSSNNITEIRSSCFP------------------ 165

  Fly   522 THLHLGSFAGLEQIQEISLSFNDITIHHPLVFENVSRTLKILELSFAVFPARSLESLDPLDALLP 586
                    .|| :::|::|:.|.|:|.....|:.:||:|..|.||                    
  Rat   166 --------NGL-RVRELNLASNRISILESGAFDGLSRSLLTLRLS-------------------- 201

  Fly   587 LSQLIWLGLDNNNLKQVSNESFAQMRELSYINLSFNQLKTLPRGLFQSDAHSHLVEIDLSYNGLE 651
                      .|.:.|:..::|                 .|||          |.::||:.|.:.
  Rat   202 ----------KNRITQLPVKAF-----------------KLPR----------LTQLDLNRNRIR 229

  Fly   652 RLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISHGAFTVLPNLAALD 716
            .:|..||..|..|:.|.||.|.|..:...||..|..:..|.|.||.||.::.|:...|..|..|.
  Rat   230 LIEGLTFQGLDSLEVLKLQRNNLSKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLH 294

  Fly   717 LMHNQLCSLSLKSFLYVSNTTTPLRLNVSHNHIASFYDE-LSSYMYIYQLDISHN---HVTKSDS 777
            |.:|.:..:....:.:.....   .|.:|.|::....:| |:....:..|.:|||   |:.:. :
  Rat   295 LSNNSISRIQRDGWSFCQKLH---ELILSFNNLTRLDEESLAELSGLSILRLSHNAISHIAEG-A 355

  Fly   778 FTNLANTLRFLNLAHNQL-GSLQ--SHAFGDLEFLEILNVAHNNLTSLRRRSFQGLNSLQELDLS 839
            |..| .:||.|.|.||:: |:::  |.||..|:.|..|.:..|.:.|:.:|:|.||.:|:.|:|.
  Rat   356 FKGL-KSLRVLELDHNEISGTIEDTSGAFMGLDNLSKLTLFGNKIKSVAKRAFSGLENLEHLNLG 419

  Fly   840 HNQLDQLQVEQFSNLRKLRILRINSN------RLRALP------------------------REV 874
            .|.:..:|.:.|:.::.|:.|.|:|.      :|:.||                        :.:
  Rat   420 ENAIRSIQFDAFAKMKNLKELYISSESFLCDCQLKWLPPWLVSRMLQAFVTATCAHPESLKGQSI 484

  Fly   875 FMNTRLEFL--DIAENQLSVWPVPAFT----DIGFTLRSIQMSHNNLEYLDASMFINSQFLYDIS 933
            |......|:  |..:.|:...|.....    ||.||..:...|.:.:                  
  Rat   485 FSVLPDSFVCDDFPKPQIITQPETTMAVVGKDIRFTCSAASSSSSPM------------------ 531

  Fly   934 LARNRITILPDNTFSFLNN---LTNLDLSQNPLVTTNLREVFVHTP--RLRKLSLHHMGLY 989
                        ||::..:   |||.|:.....|.....||..:|.  .||.::..|.|.|
  Rat   532 ------------TFAWKKDNEVLTNADMENFAHVRAQDGEVMEYTTILHLRHVTFGHEGRY 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4168NP_001285953.1 leucine-rich repeat 99..118 CDD:275380
LRR_8 121..181 CDD:290566
LRR_RI 122..350 CDD:238064
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
LRR_8 265..322 CDD:290566
leucine-rich repeat 266..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..338 CDD:275380
LRR_RI 315..546 CDD:238064 39/153 (25%)
leucine-rich repeat 339..365 CDD:275380
LRR_8 365..424 CDD:290566 13/31 (42%)
leucine-rich repeat 366..388 CDD:275380
leucine-rich repeat 389..412 CDD:275380 9/19 (47%)
LRR_8 413..470 CDD:290566 14/56 (25%)
leucine-rich repeat 414..436 CDD:275380 7/21 (33%)
leucine-rich repeat 437..459 CDD:275380 3/21 (14%)
leucine-rich repeat 460..483 CDD:275380 6/22 (27%)
LRR_8 482..545 CDD:290566 12/62 (19%)
leucine-rich repeat 484..510 CDD:275380 7/25 (28%)
leucine-rich repeat 511..534 CDD:275380 2/22 (9%)
leucine-rich repeat 535..589 CDD:275380 12/53 (23%)
LRR_RI 588..891 CDD:238064 83/341 (24%)
LRR_8 588..650 CDD:290566 10/61 (16%)
leucine-rich repeat 590..613 CDD:275380 3/22 (14%)
leucine-rich repeat 614..639 CDD:275380 3/24 (13%)
LRR_8 638..698 CDD:290566 21/59 (36%)
leucine-rich repeat 640..663 CDD:275380 8/22 (36%)
leucine-rich repeat 664..687 CDD:275380 9/22 (41%)
LRR_8 688..749 CDD:290566 15/60 (25%)
leucine-rich repeat 688..711 CDD:275380 8/22 (36%)
leucine-rich repeat 712..735 CDD:275380 4/22 (18%)
leucine-rich repeat 740..783 CDD:275380 12/46 (26%)
LRR_8 784..843 CDD:290566 23/61 (38%)
leucine-rich repeat 785..808 CDD:275380 11/25 (44%)
leucine-rich repeat 809..832 CDD:275380 8/22 (36%)
LRR_RI <827..1053 CDD:238064 41/204 (20%)
LRR_8 832..890 CDD:290566 16/89 (18%)
leucine-rich repeat 833..856 CDD:275380 6/22 (27%)
leucine-rich repeat 857..879 CDD:275380 8/51 (16%)
leucine-rich repeat 880..900 CDD:275380 4/25 (16%)
LRR_8 904..963 CDD:290566 8/61 (13%)
leucine-rich repeat 905..928 CDD:275380 1/22 (5%)
leucine-rich repeat 929..952 CDD:275380 2/22 (9%)
leucine-rich repeat 953..977 CDD:275380 8/25 (32%)
leucine-rich repeat 978..1020 CDD:275380 5/12 (42%)
LRR_8 1019..1074 CDD:290566
leucine-rich repeat 1045..1068 CDD:275380
leucine-rich repeat 1069..1090 CDD:275380
leucine-rich repeat 1091..1114 CDD:275380
leucine-rich repeat 1115..1161 CDD:275380
leucine-rich repeat 1162..1190 CDD:275380
Lrig1XP_232237.6 LRR_8 76..132 CDD:290566 21/69 (30%)
LRR_4 76..115 CDD:289563 17/37 (46%)
leucine-rich repeat 76..98 CDD:275380 10/20 (50%)
leucine-rich repeat 99..114 CDD:275380 6/14 (43%)
leucine-rich repeat 122..145 CDD:275380 9/45 (20%)
LRR_RI 138..421 CDD:238064 93/379 (25%)
LRR_8 145..228 CDD:290566 31/166 (19%)
leucine-rich repeat 146..169 CDD:275380 9/49 (18%)
leucine-rich repeat 170..193 CDD:275380 6/22 (27%)
leucine-rich repeat 194..217 CDD:275380 8/69 (12%)
LRR_8 216..276 CDD:290566 23/69 (33%)
leucine-rich repeat 218..241 CDD:275380 8/22 (36%)
leucine-rich repeat 242..265 CDD:275380 9/22 (41%)
LRR_8 264..324 CDD:290566 15/62 (24%)
leucine-rich repeat 266..289 CDD:275380 8/22 (36%)
leucine-rich repeat 290..313 CDD:275380 4/22 (18%)
LRR_8 313..372 CDD:290566 18/63 (29%)
leucine-rich repeat 314..337 CDD:275380 5/25 (20%)
leucine-rich repeat 338..361 CDD:275380 7/24 (29%)
leucine-rich repeat 362..386 CDD:275380 10/23 (43%)
LRR_8 388..444 CDD:290566 17/55 (31%)
leucine-rich repeat 389..412 CDD:275380 8/22 (36%)
LRR_4 411..>444 CDD:289563 9/32 (28%)
leucine-rich repeat 413..434 CDD:275380 6/20 (30%)
LRRCT 447..495 CDD:214507 5/47 (11%)
I-set 500..600 CDD:254352 22/111 (20%)
Ig 517..591 CDD:143165 19/94 (20%)
I-set 604..694 CDD:254352
Ig_1 621..695 CDD:143240
I-set 698..785 CDD:254352
IGc2 712..775 CDD:197706
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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