Protein Alignment CG4168 and TSKU

DIOPT Version :10

• Sequence 1: NP_609740.4
• Gene: CG4168 / 34889
• FlyBaseID: FBgn0028888
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_001305406.1
• Gene: TSKU / 25987
• HGNCID: 28850
• Length: 367
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 91/311 - (29%)
• Similarity: 142/311 - (45%)
• Gaps: 53/311 - (17%)

  Fly   723 CSLSLKSF-LYVSNTTT--------------PLRLNVSHNHIASFYDELSSYMYIYQLDISHNHV 772
            |...:::| |:.|.:.|              |:.|:.:|..::|           .:|::.:..|
Human    38 CQCEVETFGLFDSFSLTRVDCSGLGPHIMPVPIPLDTAHLDLSS-----------NRLEMVNESV 91

  Fly   773 TKSDSFTNLANTLRFLNLAHNQLGSLQSHAFGDLEFLEILNVAHNNLTSLRRRSFQGLNSLQELD 837
            .....:|.||.    |:|:||.|.|:...||..|.:||.|:::||.||:|...||.. :.|.:::
Human    92 LAGPGYTTLAG----LDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTS-SPLSDVN 151

  Fly   838 LSHNQLDQLQVEQFSNLRKLRILRIN-SNRL--RALPREVFMNTR-------LEFLDIAENQLSV 892
            ||||||.::.|..|:...:.|.|.:: |:.|  |.:|..    ||       ::.|::|.|:|..
Human   152 LSHNQLREVSVSAFTTHSQGRALHVDLSHNLIHRLVPHP----TRAGLPAPTIQSLNLAWNRLHA 212

  Fly   893 WPVPAFTDIGFTLRSIQMSHNNLEYLDASMFINSQFLYDISLAR-NRITILPDNTFSFLNNLTNL 956
              ||...|:  .||.:.:..|.|..:....|.....|..:|||. .|:..|..:.|..|..|..|
Human   213 --VPNLRDL--PLRYLSLDGNPLAVIGPGAFAGLGGLTHLSLASLQRLPELAPSGFRELPGLQVL 273

  Fly   957 DLSQNPLVTTNLREVFVHTPRLRKLSLHHMGLYVLPP---LKLPLLSYLDV 1004
            |||.||.:.....|||.....|::|.|....|..||.   |.||.|..:.|
Human   274 DLSGNPKLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLLHLPALQSVSV 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4168	NP_609740.4	PRK15370	<69..>353	CDD:185268
		leucine-rich repeat	99..118	CDD:275380
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..338	CDD:275380
		LRR	<338..651	CDD:443914
		leucine-rich repeat	339..365	CDD:275380
		leucine-rich repeat	366..388	CDD:275380
		leucine-rich repeat	389..412	CDD:275380
		leucine-rich repeat	414..436	CDD:275380
		leucine-rich repeat	437..459	CDD:275380
		leucine-rich repeat	460..483	CDD:275380
		leucine-rich repeat	484..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		leucine-rich repeat	535..589	CDD:275380
		LRR	543..971	CDD:443914	77/273 (28%)
		leucine-rich repeat	590..613	CDD:275380
		leucine-rich repeat	614..639	CDD:275380
		leucine-rich repeat	640..663	CDD:275380
		leucine-rich repeat	664..687	CDD:275380
		leucine-rich repeat	688..711	CDD:275380
		leucine-rich repeat	712..735	CDD:275380	3/12 (25%)
		leucine-rich repeat	740..783	CDD:275380	7/42 (17%)
		leucine-rich repeat	785..808	CDD:275380	9/22 (41%)
		leucine-rich repeat	809..832	CDD:275380	10/22 (45%)
		leucine-rich repeat	833..856	CDD:275380	9/22 (41%)
		leucine-rich repeat	857..879	CDD:275380	6/24 (25%)
		leucine-rich repeat	880..900	CDD:275380	6/19 (32%)
		leucine-rich repeat	905..928	CDD:275380	5/22 (23%)
		LRR	911..>1203	CDD:443914	32/98 (33%)
		leucine-rich repeat	929..952	CDD:275380	8/23 (35%)
		leucine-rich repeat	953..977	CDD:275380	10/23 (43%)
		leucine-rich repeat	978..1020	CDD:275380	11/30 (37%)
		leucine-rich repeat	1045..1068	CDD:275380
		leucine-rich repeat	1069..1090	CDD:275380
		leucine-rich repeat	1091..1114	CDD:275380
		leucine-rich repeat	1115..1161	CDD:275380
		leucine-rich repeat	1162..1190	CDD:275380
		PCC	1230..>1298	CDD:188093
TSKU	NP_001305406.1	leucine-rich repeat	76..99	CDD:275380	4/33 (12%)
		LRR	<98..>321	CDD:443914	79/235 (34%)
		leucine-rich repeat	100..123	CDD:275380	11/26 (42%)
		leucine-rich repeat	124..145	CDD:275380	10/21 (48%)
		leucine-rich repeat	147..170	CDD:275380	9/22 (41%)
		leucine-rich repeat	171..197	CDD:275380	8/29 (28%)
		leucine-rich repeat	200..219	CDD:275380	6/20 (30%)
		leucine-rich repeat	221..244	CDD:275380	5/22 (23%)
		leucine-rich repeat	245..269	CDD:275380	8/23 (35%)
		leucine-rich repeat	270..294	CDD:275380	10/23 (43%)
		leucine-rich repeat	295..316	CDD:275380	7/20 (35%)