Protein Alignment CG4168 and lron-5

DIOPT Version :10

• Sequence 1: NP_609740.4
• Gene: CG4168 / 34889
• FlyBaseID: FBgn0028888
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_497943.2
• Gene: lron-5 / 184307
• WormBaseID: WBGene00008656
• Length: 656
• Species: Caenorhabditis elegans
• Alignment Length: 698
• Identity: 154/698 - (22%)
• Similarity: 244/698 - (34%)
• Gaps: 219/698 - (31%)

  Fly   422 NRLTTVPVALSSLHHLKYLYLTSNQISQLNNLPS-----FTENLRVLSLS--------GNNFSMI 473
            ||.:.:...:|.|..::.|:|.|      .|||.     |..|||||.:|        |:.|  :
 Worm    36 NRPSLLIRTVSMLPTIRQLHLNS------LNLPQPPHFLFHPNLRVLRMSRCGMHEIPGSTF--L 92

  Fly   474 PVLGLKNYTQLSYLNMGYNSITDIPEGIFAVDSWGSNLQTILLRNNKITHLH-----LGSFAGLE 533
            |:.||:      .:::..|.:..:|..:.....:   |:.::|.||::::|.     |.....||
 Worm    93 PLPGLE------VIDLSNNHLETLPPTVLRSLKF---LRVLILSNNRLSNLDQLTWILAPGVVLE 148

  Fly   534 QIQEISLSFNDITIHHPLVFENVSRTLKILELSFAVFPARSLESLDPLDALLPLSQLIWLGLDNN 598
            |   :.||.|.|.|                ..|..|||              |:.||.   |.:.
 Worm   149 Q---LDLSGNPIAI----------------ATSMTVFP--------------PVRQLF---LSDT 177

  Fly   599 NLKQVSNESFAQMRELSYINLSFNQLKTLPRGLFQSDAHSHLVEIDLSYNGLERLEAQTFHSLGD 663
            .::.|:..:.              ..|.|| |....|...|:                ..|:|
 Worm   178 RMESVNETAI--------------MFKKLP-GKCDRDVCRHI----------------PIHNL-- 209

  Fly   664 LQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISHGAFTVLPNLAALDLMHNQLCSLSLK 728
                                |:..:..:|.|.||.:.|..||..|..|...:||
 Worm   210 --------------------NVSIITTIDFSSNRDLEIDSGALDVFSNATYVDL----------- 243

  Fly   729 SFLYVSNTTTPL-------------RLNVSHNHIASFYDELSSY-MYIYQLDISH---------- 769
                 |||..|:             .||:||..:....|..::. .:::.||||.
 Worm   244 -----SNTRLPVGFEEWLERKSRVKSLNISHCQLPLHEDTWTACGQFLHSLDISGIGAKRLRFSR 303

  Fly   770 ----NHVTKSDSFTNL----ANTLRFLNLAHNQLGSLQSHAFG-DLEFLEILNVAHNNLTSLRRR 825
                ..|...|:..:.    |.::..|:|..|..........| :|..|..|.::||.:|||...
 Worm   304 FCPIRSVFARDNLISSVYIDAVSMESLHLERNMFSEFPIPPPGVELTELHTLGLSHNLMTSLPPH 368

  Fly   826 SFQGLNSLQELDLSHNQLDQLQVEQFSNLRKLRILRINSNRLRALPREVFMNTRLEFLDIAENQL 890
            :.|...:||..|:|.|||.::..:.|.::                      ...|..||::.|||
 Worm   369 ALQSYPNLQHFDVSSNQLSEIDPQAFPSI----------------------GLGLISLDLSSNQL 411

  Fly   891 SVWPVPAFTDIGFTLRSIQMSHNNLEYLDASMFINSQFLYDISLAR---------NRITILPDNT 946
            |..|.|...    :|..:.:|.|.:.:||...|.....|..:.:|.         ||.:....:.
 Worm   412 SSLPHPILP----SLLLLDLSFNTISHLDPHFFTGLPMLQQLRIASNPTLFSRCPNRDSPCWSDH 472

  Fly   947 FSFLNNLTNLDLSQNPLVTTNLREVFVHTPRLRKLS---LHHMGLYVLPPLKLP-LLSYLDVSGN 1007
            ...|.:|.:||:|.:.|      |..:|...||.|.   |....:.::....|| .|..||:..|
 Worm   473 LDELTSLVDLDISNSGL------EFSLHWRHLRTLKSLILRGNEIRIIDSKSLPENLRTLDLGEN 531

  Fly  1008 YLQELSPLGSLRHLRHVNVSHNKLTNASCAAEHLPPSVRVLDLAHNPL 1055
            .:|..|....|.|||.:.|..|.| ...|:...:.|.:.......:||
 Worm   532 RVQFTSNFSKLEHLRDLRVDQNPL-RCDCSLYDIVPHLLNQSQISDPL 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4168	NP_609740.4	PRK15370	<69..>353	CDD:185268
		leucine-rich repeat	99..118	CDD:275380
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..338	CDD:275380
		LRR	<338..651	CDD:443914	53/246 (22%)
		leucine-rich repeat	339..365	CDD:275380
		leucine-rich repeat	366..388	CDD:275380
		leucine-rich repeat	389..412	CDD:275380
		leucine-rich repeat	414..436	CDD:275380	4/13 (31%)
		leucine-rich repeat	437..459	CDD:275380	7/26 (27%)
		leucine-rich repeat	460..483	CDD:275380	10/30 (33%)
		leucine-rich repeat	484..510	CDD:275380	2/25 (8%)
		leucine-rich repeat	511..534	CDD:275380	7/27 (26%)
		leucine-rich repeat	535..589	CDD:275380	10/53 (19%)
		LRR	543..971	CDD:443914	94/469 (20%)
		leucine-rich repeat	590..613	CDD:275380	3/22 (14%)
		leucine-rich repeat	614..639	CDD:275380	5/24 (21%)
		leucine-rich repeat	640..663	CDD:275380	2/22 (9%)
		leucine-rich repeat	664..687	CDD:275380	1/22 (5%)
		leucine-rich repeat	688..711	CDD:275380	8/22 (36%)
		leucine-rich repeat	712..735	CDD:275380	2/22 (9%)
		leucine-rich repeat	740..783	CDD:275380	11/74 (15%)
		leucine-rich repeat	785..808	CDD:275380	5/23 (22%)
		leucine-rich repeat	809..832	CDD:275380	8/22 (36%)
		leucine-rich repeat	833..856	CDD:275380	8/22 (36%)
		leucine-rich repeat	857..879	CDD:275380	0/21 (0%)
		leucine-rich repeat	880..900	CDD:275380	9/19 (47%)
		leucine-rich repeat	905..928	CDD:275380	6/22 (27%)
		LRR	911..>1203	CDD:443914	40/158 (25%)
		leucine-rich repeat	929..952	CDD:275380	5/31 (16%)
		leucine-rich repeat	953..977	CDD:275380	7/23 (30%)
		leucine-rich repeat	978..1020	CDD:275380	13/45 (29%)
		leucine-rich repeat	1045..1068	CDD:275380	2/11 (18%)
		leucine-rich repeat	1069..1090	CDD:275380
		leucine-rich repeat	1091..1114	CDD:275380
		leucine-rich repeat	1115..1161	CDD:275380
		leucine-rich repeat	1162..1190	CDD:275380
		PCC	1230..>1298	CDD:188093
lron-5	NP_497943.2	LRR	<48..>186	CDD:443914	44/190 (23%)
		leucine-rich repeat	51..72	CDD:275380	7/26 (27%)
		leucine-rich repeat	73..96	CDD:275380	8/24 (33%)
		leucine-rich repeat	97..120	CDD:275380	3/28 (11%)
		leucine-rich repeat	121..146	CDD:275380	6/24 (25%)
		leucine-rich repeat	147..168	CDD:275380	12/53 (23%)
		leucine-rich repeat	169..208	CDD:275380	10/72 (14%)
		leucine-rich repeat	209..237	CDD:275380	10/49 (20%)
		leucine-rich repeat	238..284	CDD:275380	11/61 (18%)
		leucine-rich repeat	327..351	CDD:275380	5/23 (22%)
		LRR	<348..>555	CDD:443914	62/238 (26%)
		leucine-rich repeat	352..375	CDD:275380	8/22 (36%)
		leucine-rich repeat	376..391	CDD:275380	7/14 (50%)
		leucine-rich repeat	401..445	CDD:275380	15/47 (32%)
		leucine-rich repeat	446..478	CDD:275380	5/31 (16%)
		leucine-rich repeat	479..500	CDD:275380	8/26 (31%)
		leucine-rich repeat	501..522	CDD:275380	4/20 (20%)
		leucine-rich repeat	523..544	CDD:275380	7/20 (35%)
		LRRCT	553..601	CDD:214507	6/27 (22%)