DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4168 and LRRC15

DIOPT Version :9

Sequence 1:	NP_001285953.1	Gene:	CG4168 / 34889	FlyBaseID:	FBgn0028888	Length:	1330	Species:	Drosophila melanogaster
Sequence 2:	NP_001128529.2	Gene:	LRRC15 / 131578	HGNCID:	20818	Length:	587	Species:	Homo sapiens

Alignment Length:	395	Identity:	124/395 - (31%)
Similarity:	198/395 - (50%)	Gaps:	38/395 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 ALNLEQNFVTQLPEAVF-KATGIAHLVLAFNAISRVHPSAFEGLTETLEYLDLERNRLTTVPVAL 431
            :|.:....:|:|.|:.| ..:.:..|.:..|.:||:.|.||..| .:|.||.|..|:|..:|:.|
Human    63 SLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNL-GSLRYLSLANNKLQVLPIGL 126

  Fly   432 -SSLHHLKYLYLTSNQISQLNNLPS-FTE--NLRVLSLSGNNFSMIPVLGLKNYTQLSYLNMGYN 492
             ..|..|:.|.|:|||:.|:.  |: |::  ||:.|.|.||:...||.....:...|:.||:|.|
Human   127 FQGLDSLESLLLSSNQLLQIQ--PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 189

  Fly   493 SITDIPEGIFAVDSWGSNLQTILLRNNKITHLHLGSFAGLEQIQEISLSFNDITIHHPLVFENVS 557
            |:|.|...:|   ....|||.:.|..|::|.:.:|:|.||..:||::|..|.|.:..|.:|.| :
Human   190 SLTHISPRVF---QHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN-N 250

  Fly   558 RTLKILELS-----------FAVFP--------ARSLESLDPLDALLPLSQLIWLGLDNNNLKQV 603
            ..|:.|.||           |...|        ..||:.|.| ....|:..|..|.|.:|::..:
Human   251 HNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSP-GIFGPMPNLRELWLYDNHISSL 314

  Fly   604 SNESFAQMRELSYINLSFNQLKTLPRGLFQSDAHSHLVEIDLSYNGLERLEAQTFHSLGDLQTLN 668
            .:..|:.:|:|..:.||.||:..:..|.|  :..:.|.|:.|..|.|:.|:...|..|.:||.::
Human   315 PDNVFSNLRQLQVLILSRNQISFISPGAF--NGLTELRELSLHTNALQDLDGNVFRMLANLQNIS 377

  Fly   669 LQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISHGAFTVLPNLAALDLMHNQ-LCS---LSLKS 729
            ||:||||.:..:.|.|:..|..:.|..|:|.|:..|.|..|..|..|.|..|. .|.   |.|::
Human   378 LQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRN 442

  Fly   730 FLYVS 734
            :|.::
Human   443 WLLLN 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4168	NP_001285953.1	leucine-rich repeat	99..118	CDD:275380
		LRR_8	121..181	CDD:290566
		LRR_RI	122..350	CDD:238064
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		LRR_8	265..322	CDD:290566
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..338	CDD:275380
		LRR_RI	315..546	CDD:238064	62/182 (34%)
		leucine-rich repeat	339..365	CDD:275380
		LRR_8	365..424	CDD:290566	18/56 (32%)
		leucine-rich repeat	366..388	CDD:275380	5/20 (25%)
		leucine-rich repeat	389..412	CDD:275380	8/22 (36%)
		LRR_8	413..470	CDD:290566	24/60 (40%)
		leucine-rich repeat	414..436	CDD:275380	9/22 (41%)
		leucine-rich repeat	437..459	CDD:275380	9/24 (38%)
		leucine-rich repeat	460..483	CDD:275380	7/22 (32%)
		LRR_8	482..545	CDD:290566	23/62 (37%)
		leucine-rich repeat	484..510	CDD:275380	9/25 (36%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		leucine-rich repeat	535..589	CDD:275380	19/72 (26%)
		LRR_RI	588..891	CDD:238064	47/151 (31%)
		LRR_8	588..650	CDD:290566	17/61 (28%)
		leucine-rich repeat	590..613	CDD:275380	5/22 (23%)
		leucine-rich repeat	614..639	CDD:275380	7/24 (29%)
		LRR_8	638..698	CDD:290566	21/59 (36%)
		leucine-rich repeat	640..663	CDD:275380	8/22 (36%)
		leucine-rich repeat	664..687	CDD:275380	10/22 (45%)
		LRR_8	688..749	CDD:290566	16/51 (31%)
		leucine-rich repeat	688..711	CDD:275380	8/22 (36%)
		leucine-rich repeat	712..735	CDD:275380	8/27 (30%)
		leucine-rich repeat	740..783	CDD:275380
		LRR_8	784..843	CDD:290566
		leucine-rich repeat	785..808	CDD:275380
		leucine-rich repeat	809..832	CDD:275380
		LRR_RI	<827..1053	CDD:238064
		LRR_8	832..890	CDD:290566
		leucine-rich repeat	833..856	CDD:275380
		leucine-rich repeat	857..879	CDD:275380
		leucine-rich repeat	880..900	CDD:275380
		LRR_8	904..963	CDD:290566
		leucine-rich repeat	905..928	CDD:275380
		leucine-rich repeat	929..952	CDD:275380
		leucine-rich repeat	953..977	CDD:275380
		leucine-rich repeat	978..1020	CDD:275380
		LRR_8	1019..1074	CDD:290566
		leucine-rich repeat	1045..1068	CDD:275380
		leucine-rich repeat	1069..1090	CDD:275380
		leucine-rich repeat	1091..1114	CDD:275380
		leucine-rich repeat	1115..1161	CDD:275380
		leucine-rich repeat	1162..1190	CDD:275380
LRRC15	NP_001128529.2	LRR_8	60..119	CDD:290566	18/56 (32%)
		LRR_RI	63..309	CDD:238064	80/253 (32%)
		LRR_8	88..167	CDD:290566	32/81 (40%)
		leucine-rich repeat	88..108	CDD:275380	8/20 (40%)
		leucine-rich repeat	109..156	CDD:275380	18/48 (38%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		LRR_8	180..239	CDD:290566	23/61 (38%)
		leucine-rich repeat	181..204	CDD:275380	9/25 (36%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		LRR_8	228..287	CDD:290566	14/59 (24%)
		leucine-rich repeat	229..252	CDD:275380	8/23 (35%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	5/23 (22%)
		LRR_8	299..359	CDD:290566	17/61 (28%)
		LRR_4	299..340	CDD:289563	11/40 (28%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		LRR_4	324..364	CDD:289563	13/41 (32%)
		leucine-rich repeat	325..348	CDD:275380	7/24 (29%)
		leucine-rich repeat	349..370	CDD:275380	7/20 (35%)
		LRR_8	372..430	CDD:290566	21/57 (37%)
		leucine-rich repeat	373..393	CDD:275380	9/19 (47%)
		leucine-rich repeat	397..418	CDD:275380	7/20 (35%)
		TPKR_C2	429..>468	CDD:301599	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910