DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4168 and LRRC70

DIOPT Version :9

Sequence 1:NP_001285953.1 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster
Sequence 2:NP_852607.3 Gene:LRRC70 / 100130733 HGNCID:35155 Length:622 Species:Homo sapiens


Alignment Length:636 Identity:149/636 - (23%)
Similarity:237/636 - (37%) Gaps:213/636 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   584 LLPLSQLIWLGLDNNNLKQVSNESFAQMRELSYINLSFNQLKTLPRGLFQSDAHSHLVEIDLSYN 648
            |..|..|:.|.|||:|:..|..::|.|:|.|.::.|:.|.:|.|..|:|:  ...:|..:.|.||
Human    80 LTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFK--GLLNLRNLYLQYN 142

  Fly   649 GLERLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISHGAFTVLPNLA 713
            .:..:....|:.|..:|.||||.|||..:....|..:..||.||||.|.::.||...|..|.|||
Human   143 QVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLA 207

  Fly   714 ALDLMHNQLCSLSLKSFLYVSNTTTPLRLNVSHNHIASFYDELSSYMYIYQLDISHNHVTKSDSF 778
            .|.|..|.|..:...:|                                        .|.||   
Human   208 CLYLGSNNLTKVPSNAF----------------------------------------EVLKS--- 229

  Fly   779 TNLANTLRFLNLAHNQLGSLQSHAFGDLEFLEILNVAHNNLTSLRRRSFQGLNSLQELDLSHNQL 843
                  ||.|:|:||.:.::|..||..|..||.|.:.::.:.::.|..|.|:|:|:.|.||||.|
Human   230 ------LRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDL 288

  Fly   844 DQLQVEQFSNLRKLRILRINSNRLRALPREVFMNTRLEFLDIAENQLSVWPVPAFTDIGFTLRSI 908
            :.|..:.||.|:.|..|:::.||:.::..:.|.|                       :|.:|:.:
Human   289 ENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFEN-----------------------MGASLKIL 330

  Fly   909 QMSHNNLEYLDASMFINSQFLYDISLARNRITILPDNTFSFLNNLTNLDLSQNP----------- 962
            .:|.|||                        |.|.......|::|.:|..:.||           
Human   331 NLSFNNL------------------------TALHPRVLKPLSSLIHLQANSNPWECNCKLLGLR 371

  Fly   963 ------LVTTNLREVFVHTPRLRKLSLHHMGLYVLPPLKLPLLSYLDVSGNYLQELSPLGSLRHL 1021
                  .:|.|:  ...:.|.:|..:|.::.:...      :.|.::||..:....||     |:
Human   372 DWLASSAITLNI--YCQNPPSMRGRALRYINITNC------VTSSINVSRAWAVVKSP-----HI 423

  Fly  1022 RHVNVS-----HNKLTNASCAA----------EHLP--PSVRVL--DLAHNPLR----------- 1056
            .|...:     |...||.|...          |.:|  |:.|..  :...|||.           
Human   424 HHKTTALMMAWHKVTTNGSPLENTETENITFWERIPTSPAGRFFQENAFGNPLETTAVLPVQIQL 488

  Fly  1057 --RITL---------HDLASLRHLAELNIL-DVKVTNPQAFSKLRSL------------------ 1091
              .:||         :|.||:.....|... :|:..| :||..|.:.                  
Human   489 TTSVTLNLEKNSALPNDAASMSGKTSLICTQEVEKLN-EAFDILLAFFILACVLIIFLIYKVVQF 552

  Fly  1092 -RKLHASSHANLG-------------EIVARI----------PGLQQLRVH 1118
             :||.||.::...             .:.|.|          |||:|:|:|
Human   553 KQKLKASENSRENRLEYYSFYQSARYNVTASICNTSPNSLESPGLEQIRLH 603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4168NP_001285953.1 leucine-rich repeat 99..118 CDD:275380
LRR_8 121..181 CDD:290566
LRR_RI 122..350 CDD:238064
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
LRR_8 265..322 CDD:290566
leucine-rich repeat 266..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..338 CDD:275380
LRR_RI 315..546 CDD:238064
leucine-rich repeat 339..365 CDD:275380
LRR_8 365..424 CDD:290566
leucine-rich repeat 366..388 CDD:275380
leucine-rich repeat 389..412 CDD:275380
LRR_8 413..470 CDD:290566
leucine-rich repeat 414..436 CDD:275380
leucine-rich repeat 437..459 CDD:275380
leucine-rich repeat 460..483 CDD:275380
LRR_8 482..545 CDD:290566
leucine-rich repeat 484..510 CDD:275380
leucine-rich repeat 511..534 CDD:275380
leucine-rich repeat 535..589 CDD:275380 2/4 (50%)
LRR_RI 588..891 CDD:238064 88/302 (29%)
LRR_8 588..650 CDD:290566 21/61 (34%)
leucine-rich repeat 590..613 CDD:275380 9/22 (41%)
leucine-rich repeat 614..639 CDD:275380 7/24 (29%)
LRR_8 638..698 CDD:290566 22/59 (37%)
leucine-rich repeat 640..663 CDD:275380 6/22 (27%)
leucine-rich repeat 664..687 CDD:275380 9/22 (41%)
LRR_8 688..749 CDD:290566 19/60 (32%)
leucine-rich repeat 688..711 CDD:275380 11/22 (50%)
leucine-rich repeat 712..735 CDD:275380 7/22 (32%)
leucine-rich repeat 740..783 CDD:275380 3/42 (7%)
LRR_8 784..843 CDD:290566 23/58 (40%)
leucine-rich repeat 785..808 CDD:275380 10/22 (45%)
leucine-rich repeat 809..832 CDD:275380 6/22 (27%)
LRR_RI <827..1053 CDD:238064 53/261 (20%)
LRR_8 832..890 CDD:290566 17/57 (30%)
leucine-rich repeat 833..856 CDD:275380 11/22 (50%)
leucine-rich repeat 857..879 CDD:275380 6/21 (29%)
leucine-rich repeat 880..900 CDD:275380 0/19 (0%)
LRR_8 904..963 CDD:290566 12/75 (16%)
leucine-rich repeat 905..928 CDD:275380 5/22 (23%)
leucine-rich repeat 929..952 CDD:275380 3/22 (14%)
leucine-rich repeat 953..977 CDD:275380 6/40 (15%)
leucine-rich repeat 978..1020 CDD:275380 7/41 (17%)
LRR_8 1019..1074 CDD:290566 19/95 (20%)
leucine-rich repeat 1045..1068 CDD:275380 9/46 (20%)
leucine-rich repeat 1069..1090 CDD:275380 6/21 (29%)
leucine-rich repeat 1091..1114 CDD:275380 9/64 (14%)
leucine-rich repeat 1115..1161 CDD:275380 2/4 (50%)
leucine-rich repeat 1162..1190 CDD:275380
LRRC70NP_852607.3 LRRNT 31..62 CDD:214470
LRR 1 61..82 1/1 (100%)
leucine-rich repeat 65..85 CDD:275380 2/4 (50%)
LRR_8 85..144 CDD:290566 21/60 (35%)
LRR 2 85..106 8/20 (40%)
leucine-rich repeat 86..109 CDD:275380 9/22 (41%)
LRR 3 109..130 7/22 (32%)
leucine-rich repeat 110..133 CDD:275380 7/24 (29%)
LRR_8 133..192 CDD:290566 22/58 (38%)
LRR 4 133..154 5/20 (25%)
leucine-rich repeat 134..157 CDD:275380 6/22 (27%)
LRR 5 157..178 9/20 (45%)
leucine-rich repeat 158..181 CDD:275380 9/22 (41%)
LRR_RI <159..340 CDD:238064 72/276 (26%)
LRR 6 181..202 10/20 (50%)
LRR_8 182..240 CDD:290566 28/106 (26%)
leucine-rich repeat 182..205 CDD:275380 11/22 (50%)
LRR 7 205..226 8/60 (13%)
leucine-rich repeat 206..229 CDD:275380 8/62 (13%)
LRR_8 228..288 CDD:290566 25/68 (37%)
LRR 8 229..250 10/29 (34%)
leucine-rich repeat 230..253 CDD:275380 10/22 (45%)
LRR 9 253..274 5/20 (25%)
leucine-rich repeat 254..277 CDD:275380 6/22 (27%)
LRR_8 277..337 CDD:290566 21/82 (26%)
LRR 10 277..298 9/20 (45%)
leucine-rich repeat 278..301 CDD:275380 11/22 (50%)
LRR 11 301..322 5/20 (25%)
leucine-rich repeat 302..326 CDD:275380 7/46 (15%)
LRR 12 326..347 7/44 (16%)
leucine-rich repeat 327..348 CDD:275380 7/44 (16%)
LRRCT 359..398 CDD:214507 7/40 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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