DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stc and FAP1

DIOPT Version :9

Sequence 1:	NP_476599.1	Gene:	stc / 34888	FlyBaseID:	FBgn0001978	Length:	1106	Species:	Drosophila melanogaster
Sequence 2:	NP_014375.1	Gene:	FAP1 / 855708	SGDID:	S000004968	Length:	965	Species:	Saccharomyces cerevisiae

Alignment Length:	848	Identity:	250/848 - (29%)
Similarity:	369/848 - (43%)	Gaps:	161/848 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 NKRRDDWNRNRDRINGFPRAVDDLDTSNESAHPSP-EKQSQLQQISPRRGPPLPPADNEKLSQRE 373
            |:...|..|:.:..:|...:|:|   :||  .||. |::|                 ::.:...|
Yeast    12 NQDGGDTYRHHNLSDGCISSVED---ANE--QPSSYEEES-----------------DDDMQYYE 54

  Fly   374 KLVRDIEQ-RRLECLVCVEAIKSHQPTWSCRNCYHMLHLKCTITWASSSKSEVG---WRCPACQN 434
            :.:::|.. ....|::|...:......::|:.||.:....|...||..|..:..   |:||.|..
Yeast    55 RAIQEISSGDSYVCMICTVEMDYTCQMFACKRCYRVFDYGCIREWALKSTEKTVDRIWKCPNCYY 119

  Fly   435 VLQDLP--RDYLCFCGKLKNPPVSRTELAHSCGEVCCRIEGCSHACTLLCHPGPCPPCQANVVRS 497
            |.:.:|  ....|:|||:.||..:..: .:|||:. |....|.|.|:.:||.||.|.|...|...
Yeast   120 VSKRVPVKNRPTCWCGKVVNPDPNPLD-PNSCGQT-CNASTCMHGCSKICHLGPHPECTRMVEIM 182

  Fly   498 CGCGRSTKTMQC----AMKEEVLCGEICDKLLNCGEHRCQAECHSGKCAACSEQVVQ-------- 550
            |.||:.:|::.|    .||:...|.|:|...|:|..|.|:.:||.|.|..|.|.::.
Yeast   183 CHCGKHSKSIFCYQSKVMKKNFNCQEVCGLPLSCSIHTCKKKCHPGLCGPCPEMIISKDSPKKQI 247

  Fly   551 QCHCGKQER-KVPCT--------RESQDKR------TYSCKDSCGQPLPCGHHKCKDSCHA---- 596
            :|:||...| .:.|:        :.|:|:.      .::|.|:......|..|...:||.:
Yeast   248 KCYCGNHTRANIKCSETKFPKSGKSSKDENGNRWIGVFACADNRVVDYSCRKHSFIESCISPPTI 312

  Fly   597 GSCRPCKLSPEQITSCPCGKMPVP--AGQRSSCLDPIPTCEGICSRTLRCGKPAHPHQCGSKCHL 659
            ...:.|...|..:.:||||:..:.  ...|..|.||||||:..|.:.|:|||    |.|...||.
Yeast   313 NGEKACPFLPSSLKTCPCGRTALEELTKPRKHCDDPIPTCDSRCGKPLKCGK----HSCPFTCHD 373

  Fly   660 GQC-PPCPKQTGVKCRCGHMDQMIKCRQLCNRADDARCKRRCTKKRSCGKHKCNVECC------- 716
            ..| .||.:...|||.|......:.    |......||..:|....||.:|:|...||
Yeast   374 KACMEPCLQIDSVKCACEQSTFSVP----CGFQGRPRCNIKCESLMSCRRHRCTDRCCSGRPSAI 434

  Fly   717 -----------------IDIDHDCPLPCNRTLSCGKHKCDQPCHRGNCPPCYRSSFEELYCECGA 764
                             ::..|.|..|||.|||||.|||.:.||.|.||||..|...:|.|.||.
Yeast   435 RRKKNLFRTQDLLDESLVEAKHICLKPCNLTLSCGIHKCQRKCHPGKCPPCLESDSNDLVCPCGN 499

  Fly   765 EVIYPPVPCGTKKPICKLPCSRI----HPCDHPPQ-HNCHS-GPTCPPCMIFTTKLCHGNHELRK 823
            .|:..||.||||.|.|..||.::    ..|.|.|. |.||| ..:||||.....|.|....:.:.
Yeast   500 TVVPAPVRCGTKLPTCNHPCIKVVRGESTCGHKPMPHTCHSLDVSCPPCTETVFKPCKCGKKTKV 564

  Fly   824 TIPCSQPNFSCGMACGKPLPCGGHKCIKPCH-EGPCQSAGEICRQSCTKPRPTCGHKCAAACH-E 886
            ...|.|.:.|||:.||.||....|.|.|.|| .|.||   ::|:|:|.:.|..|.|:|...|| :
Yeast   565 RTVCFQTDVSCGIKCGIPLSYCYHTCQKTCHLPGNCQ---KVCKQTCGQKRLNCNHECPKPCHGK 626

  Fly   887 GACPETPCKELVEVQCECGNRKQNRSCQELAREHSRIATIQLASSMAEMSRGNYMELSEILAPAK 951
            ..||:.||..||::.|:||..|::.:|   ..:..|:       |:.|.|
Yeast   627 TECPDLPCATLVKIYCKCGRIKKSVTC---GAKSDRV-------SVTESS--------------- 666

  Fly   952 KSNKTLDCNDECRLLERNRRLAAA---------LSSGNSDTKQKCL---TKYSEFVRGFAKKNPA 1004
                .||||:||..|:|.:.|..|         .:|...|..:|.:   |.:.|....|.:  .|
Yeast   667 ----VLDCNEECEALKRLKELKEAFGIKEETNNFTSNELDALKKLVSVATTFEELQLPFTE--AA 725

  Fly  1005 LTKSVY-------ETLTDLVKLAKESKQRSRSHSFPTMNREKRQLVHELCEVFGIESVSYDKEPN 1062
            |  |||       ..:..::....:.|.||..| |..|...:|..:.||.:.:|:.|.|.|:||.
Yeast   726 L--SVYSKQERWCSQIEAILNKLMDDKTRSSLH-FKPMRPPQRHFIRELAKAYGLYSESQDREPM 787

  Fly  1063 RNV 1065
            |:|
Yeast   788 RSV 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stc	NP_476599.1	NF-X1-zinc-finger	464..510	CDD:100116	18/49 (37%)
		NF-X1-zinc-finger	517..565	CDD:100116	18/64 (28%)
		NF-X1-zinc-finger	575..617	CDD:100116	12/45 (27%)
		NF-X1-zinc-finger	634..686	CDD:100116	17/52 (33%)
		NF-X1-zinc-finger	723..775	CDD:100116	28/51 (55%)
		NF-X1-zinc-finger	834..882	CDD:100116	21/48 (44%)
		NF-X1-zinc-finger	865..915	CDD:100116	20/50 (40%)
		R3H_NF-X1	996..1069	CDD:100072	23/77 (30%)
FAP1	NP_014375.1	RING-CH-C4HC3_NFX1	66..118	CDD:319610	12/51 (24%)
		NF-X1-zinc-finger	150..196	CDD:100116	18/46 (39%)
		NF-X1-zinc-finger	206..263	CDD:100116	18/56 (32%)
		NF-X1-zinc-finger	352..400	CDD:100116	17/55 (31%)
		NF-X1-zinc-finger	458..505	CDD:100116	25/46 (54%)
		NF-X1-zinc-finger	604..655	CDD:100116	20/53 (38%)
		R3H_unknown_2	736..794	CDD:100076	17/56 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345532
Domainoid	1	1.000	65	1.000	Domainoid score	I2405
eggNOG	1	0.900	-	-		E1_KOG1952
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1875
Inparanoid	1	1.050	376	1.000	Inparanoid score	I345
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52859
OrthoFinder	1	1.000	-	-		FOG0004250
OrthoInspector	1	1.000	-	-		oto99685
orthoMCL	1	0.900	-	-		OOG6_103027
Panther	1	1.100	-	-	LDO	PTHR12360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R432
SonicParanoid	1	1.000	-	-		X2986
TreeFam	1	0.960	-	-
	15	14.790