DRSC/TRiP Functional Genomics Resources

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Protein Alignment stc and Nfx1

DIOPT Version :10

Sequence 1:NP_476599.1 Gene:stc / 34888 FlyBaseID:FBgn0001978 Length:1106 Species:Drosophila melanogaster
Sequence 2:NP_076228.2 Gene:Nfx1 / 74164 MGIID:1921414 Length:1114 Species:Mus musculus


Alignment Length:1100 Identity:399/1100 - (36%)
Similarity:553/1100 - (50%) Gaps:143/1100 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 IMQHNLGGGAPSNATSTMQHPVGSSYTNFSLGGGGGAFGLNPPVASASTSHFANVSHQSPNFYSQ 119
            :.||:...|:...:..........|..|..|        .|.|...|     .|..||:.|..:|
Mouse    68 VHQHSYASGSKPKSPQGFFQSSNKSLKNHGL--------QNQPWQKA-----RNEKHQNRNKKAQ 119

  Fly   120 AMIPTYQNGDGIARVTVTSSYGSVNPSNSNFSSFYTPFGNNPFDFSASKLQASAPEFVPNFAKLS 184
            .:  :.|..|       |||..||..|.|         |.||.:.|.|:                
Mouse   120 GL--SEQTSD-------TSSLESVARSES---------GTNPREHSPSE---------------- 150

  Fly   185 LEETPAAATTNGNSTASLETAINETRPRTLRAQEPAERGANNQCSNHNYERERERERDRDRDRER 249
                           :..|..|.:  ||..:.::.|:       ..:||.|         ..:.:
Mouse   151 ---------------SEKEVVIAD--PRGAKPKKAAQ-------LTYNYGR---------GPKAK 182

  Fly   250 DRDRDRDRDRDRDRDRDRDSRPGNTRQQRRSD--YRDDRED-----RYERSDRRRPQKQQRYDNH 307
            .|.|....:|...:..|.::||........||  .|....|     |.|:  ||.|||:..::..
Mouse   183 GRLRSEWGNRMSPKSEDENTRPVAISHTDSSDASCRKPVVDPCVCRRNEQ--RRYPQKRPPWEVE 245

  Fly   308 RSNKR--RDDWNRNRDR-INGFPRA------VDDL---------DTSNESAHPSPEKQSQLQQIS 354
            .:..|  |:...:...| ||..|:.      .|:|         ||.|.:......::...::.:
Mouse   246 GARPRPGRNPPKQESQRHINAGPKTNMSPIPKDNLRERPTKSACDTGNLAVVSKSSRRVNQEKTA 310

  Fly   355 PRRGPP--LPP----ADNEKLSQRE----KLVRDIEQRRLECLVCVEAIKSHQPTWSCRNCYHML 409
            .||..|  |.|    ..|..|...|    .|:..:...:.||:||.|.::...|.|||::|:|:.
Mouse   311 VRRQDPQVLSPFPRGKQNHMLKNVETHTGSLIEQLTTEKYECMVCCELVQVTAPVWSCQSCFHVF 375

  Fly   410 HLKCTITWASSSKS----EVGWRCPACQNVLQDLPRDYLCFCGKLKNPPVSRTELAHSCGEVCCR 470
            ||.|...||.|..|    :.||||||||||...:|..|.|||||:|||..||.|:.|||||||.:
Mouse   376 HLNCIKKWARSPASHADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK 440

  Fly   471 I---EGCSHACTLLCHPGPCPPCQANVVRSCGCGRSTKTMQCAMKEEVLCGEICDKLLNCGEHRC 532
            .   :.|.|:|.|||||||||||.|...::|.|||:..|::|.....|.|...|:.:||||:|.|
Mouse   441 KQPGQDCPHSCNLLCHPGPCPPCPAFTTKTCECGRTRHTVRCGQPVSVHCSNACENILNCGQHHC 505

  Fly   533 QAECHSGKCAACSEQVVQQCHCGKQERKVPC---TRESQDKRTYSCKDSCGQPLPCGHHKCKDSC 594
            ...||.|:|..|...:.|.|:||...|.|.|   ..:|.....:||...||:.|.||.|.|...|
Mouse   506 AELCHGGQCQPCRIILNQVCYCGSTSRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGSHTCSQVC 570

  Fly   595 HAGSCRPCKLSPEQITSCPCGKMPVP------AGQRSSCLDPIPTCEGICSRTLRCGKPAHPHQC 653
            |...|:||...|..:..||||:.|:.      :..|.:|:||:|:|..:|.:.|.||.....|.|
Mouse   571 HPQPCQPCPRLPHLVRYCPCGQTPLSQLLEHGSNARKTCMDPVPSCGKVCGKPLACGSSDFIHTC 635

  Fly   654 GSKCHLGQCPPCPKQTGVKCRCGHMDQMIKCRQLCNRADDA--RCKRRCTKKRSCGKHKCNVECC 716
            ...||.|.|.||.:.:.:.|||....:.:.|..|  :::||  .|.:||.|||.||:||||..||
Mouse   636 EKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSL--KSEDATFMCDKRCNKKRLCGRHKCNEICC 698

  Fly   717 IDIDHDCPLPCNRTLSCGKHKCDQPCHRGNCPPCYRSSFEELYCECGAEVIYPPVPCGTKKPICK 781
            :|.:|.|||.|.|.|.||.|:|::|||||||..|:::||:||.|.|||.||||||||||:.|.|.
Mouse   699 VDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGTRPPECT 763

  Fly   782 LPCSRIHPCDHPPQHNCHSGPTCPPCMIFTTKLCHGNHELRKTIPCSQPNFSCGMACGKPLPCGG 846
            ..|:|||.||||..|:|||...||||...|.|.|.|.||||..|||...:.|||:.|...||||.
Mouse   764 QTCARIHECDHPVYHSCHSEEKCPPCTFLTQKWCMGKHELRSNIPCHLVDISCGLPCSAMLPCGM 828

  Fly   847 HKCIKPCHEGPCQSAGEICRQSCTKPRPTCGHKCAAACHEG-ACPETPCKELVEVQCECGNRKQN 910
            |||.:.||:|.| ...|.|:|.||.||..|||.|.|.||.. .||.|.||..||:|||||.||:.
Mouse   829 HKCQRLCHKGEC-LVDEACKQPCTTPRGDCGHPCMAPCHPSLPCPVTACKAKVELQCECGRRKEM 892

  Fly   911 RSCQELAREHSRIATIQLASSMAEMSRGNYMELSEILAPAKKSNKTLDCNDECRLLERNRRLAAA 975
            ..|.|.:..:.||..|.:||.:.:|..|:.:|:|:::...:.....|.|::||..|||.:|||.|
Mouse   893 VICSEASGTYQRIVAISMASKITDMQLGDSVEISKLITKKEVQQARLQCDEECAALERRKRLAEA 957

  Fly   976 LS-SGNSD--TKQKCLTKYSEFVRGFAKKNPALTKSVYETLTDLVKLAKESKQRSRSHSFPTMNR 1037
            .. :.:||  ..:...:|:|:.::..|:|:......|.:.:..||:...:.|...:||.||.|||
Mouse   958 FDITDDSDPFNVRSSASKFSDSLKDDARKDLKFVSDVEKEMETLVEAVNKGKNNKKSHCFPPMNR 1022

  Fly  1038 EKRQLVHELCEVFGIESVSYDKEPNRNVVATAHKDRCWFPATSIMEVLARESGQRRVPVP 1097
            :.|:::|:|.:|:|:||:|||.||.||||.||.:.:...|.|::..|:.||: |.|.|.|
Mouse  1023 DHRRIIHDLAQVYGLESISYDSEPKRNVVVTAVRGKSVCPPTTLTSVIERET-QTRPPPP 1081

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stcNP_476599.1 RING_Ubox 385..433 CDD:473075 24/51 (47%)
NF-X1-zinc-finger 464..510 CDD:100116 25/48 (52%)
NF-X1-zinc-finger 517..565 CDD:100116 20/50 (40%)
NF-X1-zinc-finger 575..617 CDD:100116 18/41 (44%)
NF-X1-zinc-finger 634..686 CDD:100116 17/51 (33%)
NF-X1-zinc-finger 723..775 CDD:100116 34/51 (67%)
NF-X1-zinc-finger 834..882 CDD:100116 25/47 (53%)
NF-X1-zinc-finger 865..915 CDD:100116 28/50 (56%)
R3H_NF-X1 996..1069 CDD:100072 29/72 (40%)
Nfx1NP_076228.2 Interaction with PABPC1 and PABC4. /evidence=ECO:0000250 9..26
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..220 45/231 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 232..287 13/56 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 299..325 5/25 (20%)
RING-CH-C4HC3_NFX1 350..403 CDD:438357 24/52 (46%)
NF-X1-zinc-finger 490..538 CDD:100116 20/47 (43%)
NF-X1-zinc-finger 551..593 CDD:100116 18/41 (44%)
NF-X1-zinc-finger 616..668 CDD:100116 17/51 (33%)
NF-X1-zinc-finger 678..726 CDD:100116 28/47 (60%)
NF-X1-zinc-finger 705..757 CDD:100116 34/51 (67%)
NF-X1-zinc-finger 816..861 CDD:100116 24/45 (53%)
R3H_NF-X1 981..1054 CDD:100072 29/72 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1071..1095 5/11 (45%)
Blue background indicates that the domain is not in the aligned region.

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