DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stc and NFX1

DIOPT Version :9

Sequence 1:	NP_476599.1	Gene:	stc / 34888	FlyBaseID:	FBgn0001978	Length:	1106	Species:	Drosophila melanogaster
Sequence 2:	NP_001305687.1	Gene:	NFX1 / 4799	HGNCID:	7803	Length:	1121	Species:	Homo sapiens

Alignment Length:	1041	Identity:	393/1041 - (37%)
Similarity:	543/1041 - (52%)	Gaps:	109/1041 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SVNPSNSNFSSFYTPFGNNPFDFSA----------SKLQASAPEFVPNFAKLSLEETPAAATTNG 196
            |.:||.|...|..|.|.::|.:.|.          .||:..........|:...|:|
Human    72 SYHPSGSKPKSQQTSFQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQT-------- 128

  Fly   197 NSTASLETAINETRPRTLRAQEPAE----------RGANNQCSN---HNYERERERERDRDRDRE 248
            :.||.||::........||...|:|          |||..:.:.   ::|.| ..:.:.:.:...
Human   129 SDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVYSYGR-GPKVKGKLKCEW 192

  Fly   249 RDRDRDRDRDRDRDRDR-----DRDSRPGNTRQQRRSDY--RDDREDRYERS------------D 294
            .:|...:..|...:..:     ..||...::|:.....|  |.:.:.||.:.            .
Human   193 SNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRP 257

  Fly   295 RRRPQKQQ--RYDN--HRSNK---RRDDWN----------RNRDRINGFPRAVDDLDTSNESAHP 342
            .|.|.||:  |:.|  ||:|.   .:||.|          .|...||...|.||....:.....|
Human   258 GRNPPKQEGHRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDP 322

  Fly   343 SPEKQSQLQQISP-RRGPPLPPADNEKLSQRE----KLVRDIEQRRLECLVCVEAIKSHQPTWSC 402
                    |.:|| .||     ..|..|...|    .|:..:...:.||:||.|.::...|.|||
Human   323 --------QVVSPFSRG-----KQNHVLKNVETHTGSLIEQLTTEKYECMVCCELVRVTAPVWSC 374

  Fly   403 RNCYHMLHLKCTITWASSSKSEV----GWRCPACQNVLQDLPRDYLCFCGKLKNPPVSRTELAHS 463
            ::|||:.||.|...||.|..|:.    ||||||||||...:|..|.|||||:|||..||.|:.||
Human   375 QSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHS 439

  Fly   464 CGEVCCRI---EGCSHACTLLCHPGPCPPCQANVVRSCGCGRSTKTMQCAMKEEVLCGEICDKLL 525
            |||||.:.   :.|.|:|.|||||||||||.|.:.::|.|||:..|::|.....|.|...|:.:|
Human   440 CGEVCRKKQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENIL 504

  Fly   526 NCGEHRCQAECHSGKCAACSEQVVQQCHCGKQERKVPC---TRESQDKRTYSCKDSCGQPLPCGH 587
            |||:|:|...||.|:|..|...:.|.|:||...|.|.|   ..:|.....:||...||:.|.||:
Human   505 NCGQHQCAELCHGGQCQPCQIILNQVCYCGSTSRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGN 569

  Fly   588 HKCKDSCHAGSCRPCKLSPEQITSCPCGKMPVP------AGQRSSCLDPIPTCEGICSRTLRCGK 646
            |.|...||...|:.|...|:.:..||||:.|:.      :..|.:|:||:|:|..:|.:.|.||.
Human   570 HTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVCGKPLPCGS 634

  Fly   647 PAHPHQCGSKCHLGQCPPCPKQTGVKCRCGHMDQMIKCRQLCNRADDA-RCKRRCTKKRSCGKHK 710
            ....|.|...||.|.|.||.:.:.:.|||....:.:.|..|.:.||.. .|.:||.|||.||:||
Human   635 LDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEADATFMCDKRCNKKRLCGRHK 699

  Fly   711 CNVECCIDIDHDCPLPCNRTLSCGKHKCDQPCHRGNCPPCYRSSFEELYCECGAEVIYPPVPCGT 775
            ||..||:|.:|.|||.|.|.|.||.|:|::|||||||..|:::||:||.|.|||.||||||||||
Human   700 CNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQASFDELTCHCGASVIYPPVPCGT 764

  Fly   776 KKPICKLPCSRIHPCDHPPQHNCHSGPTCPPCMIFTTKLCHGNHELRKTIPCSQPNFSCGMACGK 840
            :.|.|...|:|:|.||||..|:|||...||||...|.|.|.|.||.|..|||...:.|||:.|..
Human   765 RPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFLTQKWCMGKHEFRSNIPCHLVDISCGLPCSA 829

  Fly   841 PLPCGGHKCIKPCHEGPCQSAGEICRQSCTKPRPTCGHKCAAACHEGA-CPETPCKELVEVQCEC 904
            .||||.|||.:.||:|.| ...|.|:|.||.||..|||.|.|.||..: ||.|.||..||:||||
Human   830 TLPCGMHKCQRLCHKGEC-LVDEPCKQPCTTPRADCGHPCMAPCHTSSPCPVTACKAKVELQCEC 893

  Fly   905 GNRKQNRSCQELAREHSRIATIQLASSMAEMSRGNYMELSEILAPAKKSNKTLDCNDECRLLERN 969
            |.||:...|.|.:..:.|||.|.:||.:.:|..|..:|:|:::...:.....|:|::||..|||.
Human   894 GRRKEMVICSEASSTYQRIAAISMASKITDMQLGGSVEISKLITKKEVHQARLECDEECSALERK 958

  Fly   970 RRLAAALS-SGNSD--TKQKCLTKYSEFVRGFAKKNPALTKSVYETLTDLVKLAKESKQRSRSHS 1031
            :|||.|.. |.:||  ..:...:|:|:.::..|:|:......|.:.:..||:...:.|...:|||
Human   959 KRLAEAFHISEDSDPFNIRSSGSKFSDSLKEDARKDLKFVSDVEKEMETLVEAVNKGKNSKKSHS 1023

  Fly  1032 FPTMNREKRQLVHELCEVFGIESVSYDKEPNRNVVATAHKDRCWFPATSIMEVLARESGQRRVPV 1096
            ||.|||:.|:::|:|.:|:|:||||||.||.||||.||.:.:...|.|::..||.||. |.|.|.
Human  1024 FPPMNRDHRRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREM-QARPPP 1087

  Fly  1097 P 1097
            |
Human  1088 P 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stc	NP_476599.1	NF-X1-zinc-finger	464..510	CDD:100116	25/48 (52%)
		NF-X1-zinc-finger	517..565	CDD:100116	20/50 (40%)
		NF-X1-zinc-finger	575..617	CDD:100116	17/41 (41%)
		NF-X1-zinc-finger	634..686	CDD:100116	17/51 (33%)
		NF-X1-zinc-finger	723..775	CDD:100116	34/51 (67%)
		NF-X1-zinc-finger	834..882	CDD:100116	25/47 (53%)
		NF-X1-zinc-finger	865..915	CDD:100116	28/50 (56%)
		R3H_NF-X1	996..1069	CDD:100072	31/72 (43%)
NFX1	NP_001305687.1	Interaction with PABPC1 and PABC4. /evidence=ECO:0000269\|PubMed:17267499	9..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..295		48/231 (21%)
		NF-X1-zinc-finger	496..544	CDD:100116	20/47 (43%)
		NF-X1-zinc-finger	557..599	CDD:100116	17/41 (41%)
		NF-X1-zinc-finger	622..674	CDD:100116	17/51 (33%)
		NF-X1-zinc-finger	685..733	CDD:100116	28/47 (60%)
		NF-X1-zinc-finger	712..764	CDD:100116	34/51 (67%)
		NF-X1-zinc-finger	823..868	CDD:100116	24/45 (53%)
		R3H_NF-X1	988..1061	CDD:100072	31/72 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1082..1110		4/7 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156871
Domainoid	1	1.000	128	1.000	Domainoid score	I5348
eggNOG	1	0.900	-	-		E1_KOG1952
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1875
Inparanoid	1	1.050	739	1.000	Inparanoid score	I595
Isobase	1	0.950	-	0	Normalized mean entropy	S2168
OMA	1	1.010	-	-		QHG52859
OrthoDB	1	1.010	-	-		D299100at2759
OrthoFinder	1	1.000	-	-		FOG0004250
OrthoInspector	1	1.000	-	-		oto90137
orthoMCL	1	0.900	-	-		OOG6_103027
Panther	1	1.100	-	-	LDO	PTHR12360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R432
SonicParanoid	1	1.000	-	-		X2986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750