DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stc and NFXL1

DIOPT Version :9

Sequence 1:	NP_476599.1	Gene:	stc / 34888	FlyBaseID:	FBgn0001978	Length:	1106	Species:	Drosophila melanogaster
Sequence 2:	NP_001265552.1	Gene:	NFXL1 / 152518	HGNCID:	18726	Length:	911	Species:	Homo sapiens

Alignment Length:	778	Identity:	233/778 - (29%)
Similarity:	330/778 - (42%)	Gaps:	184/778 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 DNEKLSQREKLVRDIEQR-RLECLVCVEAIKSHQPTWSCRNCYHMLHLKCTITWASSS------- 421
            |..:|.:.::.|.:..|. .:.||:|:.::|.:|..|||..|:.:.|:.|...||..|
Human   138 DTRELERTKQYVNEAFQAGAMTCLICIASVKRNQAVWSCSGCFCIFHMPCIQKWAKDSQFLVSSV 202

  Fly   422 ------KSEVGWRCPAC--QNVLQDLPRDYLCFCGKLKNPPVSRTELAHSCGEVCCR--IEGCSH 476
                  |.:..|.||.|  :....:.|..|.|:|||:::||:....:.||||:||.|  ...|.|
Human   203 TDDDFGKKDCPWPCPKCRFEYKRSETPSRYYCYCGKVEDPPLDPWLVPHSCGQVCEREFKPPCGH 267

  Fly   477 ACTLLCHPGPCPPCQANVVRSCGCGRSTK-TMQCAMKE---EVLCGEICDKLLNCGEHRCQAECH 537
            .|.|||||||||||...|..:|.|.::.. ..:|:.||   ::.||:   ||| ||:|:|:..||
Human   268 KCLLLCHPGPCPPCPKMVTTTCYCKKAKPIPRRCSAKEWSCQLPCGQ---KLL-CGQHKCENPCH 328

  Fly   538 SGKCAACSEQVVQQCHCGKQERKVPCTRESQDKRTYSCKDSCGQPLPCGHHKCKDSCHAGSCRPC 602
            :|.|..|.....|:|.|||:..:..|.     ...:.|...||:.||||:|.|:..||.|:|..|
Human   329 AGSCQPCPRVSRQKCVCGKKVAERSCA-----SPLWHCDQVCGKTLPCGNHTCEQVCHVGACGEC 388

  Fly   603 KLSPEQITSCPC--GKMPVPAGQRSSCLDPIPTCEGICSRTLRCGKPAHPHQCGSKCHLGQCPPC 665
            ..|.::.  |||  .|..:|      |.:.:|||...|.:.|.||    .|:|..:||.|.|..|
Human   389 PRSGKRF--CPCQKSKFSLP------CTEDVPTCGDSCDKVLECG----IHRCSQRCHRGPCETC 441

  Fly   666 PKQTGVKCRCGHMDQMIKCRQLCNRADDARCKRRCTKKRSCGKHKCNVECCIDIDHDCPLPCNRT 730
            .::....||||...:.:.|.:      ...|:.:|.|.|.|.||:|..:||......|...|.||
Human   442 RQEVEKHCRCGKHTKRMPCHK------PYLCETKCVKMRDCQKHQCRRKCCPGNCPPCDQNCGRT 500

  Fly   731 LSCGKHKCDQPCHRGNCPPCYRSSFEELYCECGAEVIYPPVPCG----TKKPICKLPCSRIHPCD 791
            |.|..|||...||||:|.||..:  .::.|.||...:  .||||    |:.|.||..|||...|.
Human   501 LGCRNHKCPSVCHRGSCYPCPET--VDVKCNCGNTKV--TVPCGRERTTRPPKCKEQCSRPPTCH 561

  Fly   792 HPPQ--HNCHSG-------------------------------------PT-------------- 803
            |..|  |.||.|                                     ||
Human   562 HTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQT 626

  Fly   804 ---CPPCMIFTTKLCHGNHELRKTIPCSQPN-FSCGMACGKPLPCGGHKCIKPCHE--------G 856
               ||||.:.....|.|.||: ..:||.... :||...||:.|.|..|.|:|.||:        |
Human   627 ALPCPPCQVPIPMECLGKHEV-SPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTG 690

  Fly   857 PCQSAGEI--CRQSCTKPRPT-CGHKCAAACHEGACPETPCKELVEVQCECG------------- 905
            ..::..|.  |.:.|:|.||. |.|.|...||.|.||  ||.:::.::|.|.
Human   691 KNKAGPECLHCEEGCSKSRPLGCLHPCILRCHPGECP--PCVQMLRIKCHCKITSLYVECRKITT 753

  Fly   906 ---NRKQNRSC------QELAREHSRIATIQLASSMAEMSRG-----NYMELSEILAPAKKSNKT 956
               |.|...||      :||...|          ...||...     |..:..::..|.|:..|.
Human   754 ADVNEKNLLSCCKNQCPKELPCGH----------RCKEMCHPGECPFNCNQKVKLRCPCKRIKKE 808

  Fly   957 LDCND--------EC-RLLERNRRLAAALSSGNSDT--------KQKCLTKYSEFVRGFAKKN 1002
            |.||.        || ...:..:|.|:.:....:..        :|..|..:...::|..|||
Human   809 LQCNKVRENQVSIECDTTCKEMKRKASEIKEAEAKAALEEEKRRQQAELEAFENRLKGRRKKN 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stc	NP_476599.1	NF-X1-zinc-finger	464..510	CDD:100116	22/48 (46%)
		NF-X1-zinc-finger	517..565	CDD:100116	20/47 (43%)
		NF-X1-zinc-finger	575..617	CDD:100116	18/43 (42%)
		NF-X1-zinc-finger	634..686	CDD:100116	17/51 (33%)
		NF-X1-zinc-finger	723..775	CDD:100116	23/55 (42%)
		NF-X1-zinc-finger	834..882	CDD:100116	20/58 (34%)
		NF-X1-zinc-finger	865..915	CDD:100116	21/72 (29%)
		R3H_NF-X1	996..1069	CDD:100072	4/7 (57%)
NFXL1	NP_001265552.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76
		NF-X1-zinc-finger	308..356	CDD:100116	20/56 (36%)
		NF-X1-zinc-finger	361..409	CDD:100116	21/55 (38%)
		NF-X1-zinc-finger	414..462	CDD:100116	17/51 (33%)
		NF-X1-zinc-finger	493..541	CDD:100116	22/51 (43%)
		NF-X1-zinc-finger	701..748	CDD:100116	17/48 (35%)
		NF-X1-zinc-finger	765..811	CDD:100116	10/55 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1952
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D299100at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820