DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stc and Nfxl1

DIOPT Version :9

Sequence 1:	NP_476599.1	Gene:	stc / 34888	FlyBaseID:	FBgn0001978	Length:	1106	Species:	Drosophila melanogaster
Sequence 2:	NP_598682.2	Gene:	Nfxl1 / 100978	MGIID:	1923646	Length:	918	Species:	Mus musculus

Alignment Length:	693	Identity:	212/693 - (30%)
Similarity:	304/693 - (43%)	Gaps:	143/693 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 DNEKLSQREKLVRDIEQR-RLECLVCVEAIKSHQPTWSCRNCYHMLHLKCTITWASSS------- 421
            |..:|.:.::.:.:..|. .:.||:|:.::|.:|..|||..|:.:.|:.|...||..|
Mouse   145 DIHELERTKQYLNEAFQAGAMTCLICIASVKRNQAVWSCSGCFCIFHMPCIQKWAKDSQFLVSSV 209

  Fly   422 ------KSEVGWRCPAC--QNVLQDLPRDYLCFCGKLKNPPVSRTELAHSCGEVCCR--IEGCSH 476
                  |.:..|.||.|  :....:.|..|.|:|||:::||:....:.||||:||.|  ...|.|
Mouse   210 TDDDFGKKDYPWPCPKCRFEYKRSETPSRYYCYCGKVEDPPLDPWLVPHSCGQVCEREFKPSCGH 274

  Fly   477 ACTLLCHPGPCPPCQANVVRSCGCGRSTKTMQCAMKEEVLCGEICDKLLNCGEHRCQAECHSGKC 541
            .|.|||||||||||...|..:|.|.::....:....::..|...|.:.|.||.|:|:..||:|.|
Mouse   275 KCLLLCHPGPCPPCPKMVTTTCYCKKAKPIPRRCSAKQWSCQLPCGRKLLCGHHKCENPCHAGNC 339

  Fly   542 AACSEQVVQQCHCGKQERKVPCTRESQDKRTYSCKDSCGQPLPCGHHKCKDSCHAGSCRPCKLSP 606
            ..|.....|:|.|||:..:..|.     ...:.|...||:.||||:|.|:..||.|:|..|..|.
Mouse   340 QPCPRVSRQKCVCGKKVAERSCA-----SPVWHCDQVCGKTLPCGNHTCEQVCHVGACGECPRSG 399

  Fly   607 EQITSCPC--GKMPVPAGQRSSCLDPIPTCEGICSRTLRCGKPAHPHQCGSKCHLGQCPPCPKQT 669
            ::  ||||  .|..:|      |.:.:|||...|.:.|.||    .|:|..:||.|.|..|.::.
Mouse   400 KR--SCPCQKSKFSLP------CTEDVPTCGDSCDKILECG----IHRCSQRCHRGPCETCRQEV 452

  Fly   670 GVKCRCGHMDQMIKCRQLCNRADDARCKRRCTKKRSCGKHKCNVECCIDIDHDCPLPCNRTLSCG 734
            ..:||||...:.:.|.:      ...|:.:|.|.|.|.||:|..:||......|...|.|||.|.
Mouse   453 EKQCRCGKHTKRMPCHK------PYLCETKCVKMRDCQKHQCRRKCCPGNCPPCDQNCGRTLGCR 511

  Fly   735 KHKCDQPCHRGNCPPCYRSSFEELYCECG-AEVIYPPVPCG----TKKPICKLPCSRIHPCDHPP 794
            .|||...||||:|.||..:  .::.|.|| |:|   .||||    |:.|.||..|||...|.|..
Mouse   512 NHKCPSVCHRGSCYPCPET--VDVKCNCGNAKV---TVPCGRERTTRPPKCKELCSRPPTCHHAS 571

  Fly   795 Q--HNCHSGP------------------------------------------------------T 803
            |  |.||.||                                                      .
Mouse   572 QEKHRCHFGPCPPCHQPCQKVLEKCGHLCPESCHDQALVKQTGRHQPSGPWEQPAEPAFIQTALP 636

  Fly   804 CPPCMIFTTKLCHGNHELRKTIPCSQPN-FSCGMACGKPLPCGGHKCIKPCHE--------GPCQ 859
            ||||.:.....|.|.||: ..:||.... :||...||:.|.|..|.|:|.||:        |..:
Mouse   637 CPPCQVPIPVECLGKHEV-SPLPCHAVGPYSCKRLCGRMLRCQNHTCMKECHKVTEVDSSTGKNK 700

  Fly   860 SAGEI--CRQSCTKPRPT-CGHKCAAACHEGACPETPCKELVEVQCECGNRKQNRSCQELAREHS 921
            :..|.  |.:.|:|.||. |.|.|...||.|.||  ||.:::.::|.|........|:::
Mouse   701 AGPECFHCEEGCSKSRPAGCPHPCVLPCHPGKCP--PCVQMLRIKCHCKITSLYVECRKI----- 758

  Fly   922 RIATIQLASSMAEMSRGNYMELSEILAPAKKSNKTLDCNDECR 964
                     :.|::|..|.:...:...|     |.|.|...|:
Mouse   759 ---------TTADVSEKNLLSCCKNQCP-----KELPCGHRCK 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stc	NP_476599.1	NF-X1-zinc-finger	464..510	CDD:100116	22/47 (47%)
		NF-X1-zinc-finger	517..565	CDD:100116	18/47 (38%)
		NF-X1-zinc-finger	575..617	CDD:100116	19/43 (44%)
		NF-X1-zinc-finger	634..686	CDD:100116	17/51 (33%)
		NF-X1-zinc-finger	723..775	CDD:100116	25/56 (45%)
		NF-X1-zinc-finger	834..882	CDD:100116	20/58 (34%)
		NF-X1-zinc-finger	865..915	CDD:100116	18/50 (36%)
		R3H_NF-X1	996..1069	CDD:100072
Nfxl1	NP_598682.2	RING-CH finger (C4HC3-type)	167..226	CDD:319611	18/58 (31%)
		NF-X1-zinc-finger	315..363	CDD:100116	18/52 (35%)
		NF-X1-zinc-finger	368..416	CDD:100116	22/55 (40%)
		NF-X1-zinc-finger	421..469	CDD:100116	17/51 (33%)
		NF-X1-zinc-finger	500..548	CDD:100116	24/52 (46%)
		NF-X1-zinc-finger	708..755	CDD:100116	17/48 (35%)
		NF-X1-zinc-finger	772..818	CDD:100116	5/21 (24%)
		RING-CH-C4HC3_NFXL1	165..227	CDD:319611	18/61 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1952
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D299100at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820