DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stc and nfxl1

DIOPT Version :9

Sequence 1:	NP_476599.1	Gene:	stc / 34888	FlyBaseID:	FBgn0001978	Length:	1106	Species:	Drosophila melanogaster
Sequence 2:	XP_002666590.3	Gene:	nfxl1 / 100333008	ZFINID:	ZDB-GENE-110411-178	Length:	885	Species:	Danio rerio

Alignment Length:	893	Identity:	259/893 - (29%)
Similarity:	366/893 - (40%)	Gaps:	199/893 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 RDRDRDRDRDRDRDSRPGNTRQQRR-----SDYR---DDREDRYERSDRRRPQKQQRYDNHRSNK 311
            |.:.|.|.:.:.|....||....|.     |..:   ..|.|..::|||...|:........|::
Zfish     6 RQQGRGRGQGQGRGQVTGNPSSGRARGAVGSQVKASSQSRFDEIQKSDRAAAQRLTTDTYSSSSE 70

  Fly   312 RRDDWNRNRDRINGFPRAVDDLDTSNESAHPSPEKQSQLQQISPRRGPPLPPADNEKLSQREKLV 376
            ..||                  |.|.:........:|.|...:...|    ..|...|.|....:
Zfish    71 DEDD------------------DDSEDGGKRGKILKSALSPYASHTG----DTDGRLLEQTRHYL 113

  Fly   377 RDI-EQRRLECLVCVEAIKSHQPTWSCRNCYHMLHLKCTITWASSS-------------KSEVGW 427
            .:: :...:.||:|:.:::..||.|||..||.:.|:.|...||..|             |.:..|
Zfish   114 HEVCQSGGVTCLICIASVRRTQPVWSCVGCYCIFHITCIQKWAKDSIFLVSSVTDEDFGKKDHPW 178

  Fly   428 RCPACQNVL--QDLPRDYLCFCGKLKNPPVSRTELAHSCGEVCCR--IEGCSHACTLLCHPGPCP 488
            .||.|::..  ...|..|.|:|||...|......|.||||:||.|  ...|.|.|.|||||||||
Zfish   179 PCPKCRHEYSPHQTPTRYYCYCGKEAEPAPDPWLLPHSCGQVCGREFKPSCGHRCLLLCHPGPCP 243

  Fly   489 PCQANVVRSCGCGRSTKTMQCAMKEEVLCGEICDKLLNCGEHRCQAECHSGKCAACSEQVVQQCH 553
            ||...|..||.||:|::..:....:...|.:||.:.|.|..|.|...||:|:||||....:|.|.
Zfish   244 PCPQMVSVSCLCGKSSRVPRRCSAKAWSCTKICGRKLPCRTHTCANTCHAGECAACPRVSLQACA 308

  Fly   554 CGKQERKVPCTRESQDKRTYSCKDSCGQPLPCGHHKCKDSCHAGSCRPCKLSPEQITSCPCGK-- 616
            ||:|..:.||....     :.|...||:||.||:|||:..||||.|..|..:..:  ||.|||
Zfish   309 CGRQRAERPCASPE-----WHCDQVCGRPLSCGNHKCERVCHAGVCGECPRAGNR--SCSCGKTK 366

  Fly   617 --MPVPAGQRSSCLDPIPTCEGICSRTLRCGKPAHPHQCGSKCHLGQCPPCPKQTGVKCRCGHMD 679
              :|        |...:|||...|.:.|.||.    |.|..:||.|.|..|.::....||||...
Zfish   367 SVLP--------CTVDVPTCGDTCGKNLDCGL----HTCSMRCHRGACETCRQEVEKTCRCGRYS 419

  Fly   680 QMIKCRQLCNRADDARCKRRCTKKRSCGKHKCNVECCIDIDHDCPLPCNRTLSCGKHKCDQPCHR 744
            :::.|.:      :..|:.:|.|.|:|.:|:|..:||......|.:.|.|.|.|..|||...||:
Zfish   420 KLLPCHK------EYLCESKCNKTRACSRHQCKRKCCPGNCPPCDMNCGRMLGCRNHKCPSVCHQ 478

  Fly   745 GNCPPCYRSSFEELYCECGAEVIYPPVPCG----TKKPICKLPCSRIHPCDHPPQ--HNCHSGP- 802
            |:|.||  ....::.||||:.||  .||||    ||.|.||..|.:...|.|..|  |.||.||
Zfish   479 GSCYPC--PEMVKVGCECGSTVI--SVPCGRERSTKPPRCKELCKKPPSCHHASQEKHRCHFGPC 539

  Fly   803 -----------------------------------------------------TCPPCMIFTTKL 814
                                                                 .||||::.....
Zfish   540 PPCKQPCQLTLAGCVHLCPAPCHDQVLVKATDRANLAGPWEQPSTPAFVRTALPCPPCLVPIPTA 604

  Fly   815 CHGNHELRKTIPC-SQPNFSCGMACGKPLPCGGHKCIKPCHE-GPCQSAGEI--------CRQSC 869
            |.|.||: ..:|| ::..||||..||:.|.||.|||...||. .|..::.:.        |.:.|
Zfish   605 CLGEHEV-SPVPCHARGPFSCGRLCGRTLSCGNHKCSLECHHVTPTPNSDKTMAGQECVRCEEGC 668

  Fly   870 TKPRPT-CGHKCAAACHEGACPETPCKELVEVQCEC-----------------GNRKQNRSCQ-- 914
            .||||. |.|.|...||..|||  ||:.::..:|.|                 .:::...|||
Zfish   669 VKPRPAGCAHPCVLPCHRSACP--PCQLMLRQRCHCKISSLYIECLKFTSADEQDKQLLMSCQNQ 731

  Fly   915 ---ELAREHSRIATIQLASSMAEMSRGNYMELSEILAPAKKSNK------------TLDCNDECR 964
               :|...|    ..:|.....:..: |..:..:|..|.|:..|            .|.|::.|:
Zfish   732 CPKQLLCGH----RCKLLCHAGDCDQ-NCGQKVKIRCPCKRIKKDFPCSRVQSQDGLLVCDETCQ 791

  Fly   965 LLERNRRLAA-----ALSSGNSDTKQKCLTKYSEFVRGFAKKNPALTK 1007
            .|::....|.     ||..|....:|..|..:.:..:|..|||..:|:
Zfish   792 TLQKKHAEACAAEERALLEGEMRKQQAELEAFEKRQKGRRKKNRKVTE 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stc	NP_476599.1	NF-X1-zinc-finger	464..510	CDD:100116	25/47 (53%)
		NF-X1-zinc-finger	517..565	CDD:100116	21/47 (45%)
		NF-X1-zinc-finger	575..617	CDD:100116	21/45 (47%)
		NF-X1-zinc-finger	634..686	CDD:100116	17/51 (33%)
		NF-X1-zinc-finger	723..775	CDD:100116	24/55 (44%)
		NF-X1-zinc-finger	834..882	CDD:100116	22/57 (39%)
		NF-X1-zinc-finger	865..915	CDD:100116	21/72 (29%)
		R3H_NF-X1	996..1069	CDD:100072	5/12 (42%)
nfxl1	XP_002666590.3	NF-X1-zinc-finger	272..320	CDD:100116	21/47 (45%)
		NF-X1-zinc-finger	325..372	CDD:100116	22/56 (39%)
		NF-X1-zinc-finger	378..426	CDD:100116	17/51 (33%)
		NF-X1-zinc-finger	457..505	CDD:100116	23/51 (45%)
		NF-X1-zinc-finger	728..776	CDD:100116	10/52 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1952
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D299100at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820