DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZSCAN12

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001156863.1	Gene:	ZSCAN12 / 9753	HGNCID:	13172	Length:	611	Species:	Homo sapiens

Alignment Length:	274	Identity:	101/274 - (36%)
Similarity:	130/274 - (47%)	Gaps:	43/274 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 EISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAA--- 355
            |..|||..|.|.||....|..|::.|...: |.|.||||.|||.....:|:.:|...|.:..
Human   327 EKPYKCNECGKAFGRWSALNQHQRLHTGEKHYHCNDCGKAFSQKAGLFHHIKIHTRDKPYQCTQC 391

  Fly   356 -----------------------ECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVA 397
                                   ||.||||.|.....|.||.:||...|.|:|..|.|||:|. .
Human   392 NKSFSRRSILTQHQGVHTGAKPYECNECGKAFVYNSSLVSHQEIHHKEKCYQCKECGKSFSQS-G 455

  Fly   398 FNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHS 462
            ...|.|||||.||:||:.|.|.|.::..|.:|.|.|:||:||:|..|||:|..||.:|.|.|:|:
Human   456 LIQHQRIHTGEKPYKCDVCEKAFIQRTSLTEHQRIHTGERPYKCDKCGKAFTQRSVLTEHQRIHT 520

  Fly   463 GIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTH-----------A 516
            |.:|:.|..|..||.....|..|...|||.|||.|  ..|.:||.|.|::..|           .
Human   521 GERPYKCDECGNAFRGITSLIQHQRIHTGEKPYQC--DECGKAFRQRSDLSKHQRIHNRRGTYVC 583

  Fly   517 KKC--QYRPLDGLT 528
            |:|  .:|....||
Human   584 KECGKSFRQNSALT 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	81/212 (38%)
		C2H2 Zn finger	327..347	CDD:275368	9/19 (47%)
		zf-C2H2	356..377	CDD:278523	10/20 (50%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	12/24 (50%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..422	CDD:290200	13/24 (54%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..449	CDD:290200	12/22 (55%)
		zf-C2H2	439..461	CDD:278523	11/21 (52%)
		C2H2 Zn finger	441..461	CDD:275368	10/19 (53%)
		zf-C2H2	467..489	CDD:278523	6/21 (29%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..515	CDD:275368	6/17 (35%)
ZSCAN12	NP_001156863.1	SCAN	42..152	CDD:128708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..175
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..264
		C2H2 Zn finger	248..268	CDD:275368
		C2H2 Zn finger	276..296	CDD:275368
		COG5048	299..579	CDD:227381	96/254 (38%)
		C2H2 Zn finger	304..324	CDD:275368
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	388..408	CDD:275368	0/19 (0%)
		C2H2 Zn finger	416..436	CDD:275368	9/19 (47%)
		C2H2 Zn finger	444..463	CDD:275368	8/19 (42%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		C2H2 Zn finger	499..519	CDD:275368	10/19 (53%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		C2H2 Zn finger	555..575	CDD:275368	7/21 (33%)
		C2H2 Zn finger	583..603	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910