DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF264

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_003408.1	Gene:	ZNF264 / 9422	HGNCID:	13057	Length:	627	Species:	Homo sapiens

Alignment Length:	404	Identity:	126/404 - (31%)
Similarity:	178/404 - (44%)	Gaps:	75/404 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 LQQQQQPLIRTKSTACTRPDCPECLDYYQRLQTGGYKQTAP-LISPAASSVSSSTGSIRPVRDLI 230
            |:..|:|.  |:....::..||.        ..|..|.|.| ...||.|...|..|.:  .:...
Human    66 LEHGQEPW--TRKEDLSQDTCPG--------DKGKPKTTEPTTCEPALSEGISLQGQV--TQGNS 118

  Fly   231 MSATGGAASTNISLTTVT----NLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIG----- 286
            :.:..|.|.....|:.:.    ...::..:.:...|.|:..|      :|:..|....||
Human   119 VDSQLGQAEDQDGLSEMQEGHFRPGIDPQEKSPGKMSPECDG------LGTADGVCSRIGQEQVS 177

  Fly   287 ------GYNATSA--------EEISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQ 336
                  .:|:..:        ||.::||..|.|||.....|..|||.|...: |||.:|||.|.:
Human   178 PGDRVRSHNSCESGKDPMIQEEENNFKCSECGKVFNKKHLLAGHEKIHSGVKPYECTECGKTFIK 242

  Fly   337 LRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMH 401
            ..:...|..:|.|.:.:  ||.||||.||.|.||:.|.:||...|.|:|..|.|:|..|..|.:|
Human   243 STHLLQHHMIHTGERPY--ECMECGKAFNRKSYLTQHQRIHSGEKPYKCNECGKAFTHRSNFVLH 305

  Fly   402 VRIHTGVK----------------------------PHKCNECGKRFSRKMLLKQHMRTHSGEKP 438
            .|.|||.|                            |::|.||||.|..:..|..|.:||:||||
Human   306 NRRHTGEKSFVCTECGQVFRHRPGFLRHYVVHSGENPYECLECGKVFKHRSYLMWHQQTHTGEKP 370

  Fly   439 YQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCN 503
            |:||.|||.|.:.:.:..|:.:|:|.|||.|..|.|||..:.:||.|...|||.||:||  ..|.
Human   371 YECSECGKVFLESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPFVC--SECG 433

  Fly   504 QAFTQSSNMRTHAK 517
            :|||..|....|.:
Human   434 KAFTHCSTFILHKR 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	9/19 (47%)
		COG5048	<316..502	CDD:227381	85/214 (40%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-C2H2	356..377	CDD:278523	12/20 (60%)
		C2H2 Zn finger	357..377	CDD:275368	11/19 (58%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..422	CDD:290200	14/52 (27%)
		C2H2 Zn finger	413..433	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..449	CDD:290200	14/22 (64%)
		zf-C2H2	439..461	CDD:278523	8/21 (38%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-C2H2	467..489	CDD:278523	9/21 (43%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	6/17 (35%)
ZNF264	NP_003408.1	KRAB	14..74	CDD:214630	3/9 (33%)
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..155		15/90 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..194		1/19 (5%)
		COG5048	184..568	CDD:227381	101/268 (38%)
		C2H2 Zn finger	205..225	CDD:275368	9/19 (47%)
		zf-H2C2_2	221..240	CDD:290200	10/18 (56%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		zf-H2C2_2	245..270	CDD:290200	10/26 (38%)
		C2H2 Zn finger	261..281	CDD:275368	11/19 (58%)
		zf-H2C2_2	273..298	CDD:290200	11/24 (46%)
		C2H2 Zn finger	289..309	CDD:275368	8/19 (42%)
		C2H2 Zn finger	317..337	CDD:275368	0/19 (0%)
		zf-C2H2	343..365	CDD:278523	8/21 (38%)
		C2H2 Zn finger	345..365	CDD:275368	8/19 (42%)
		zf-H2C2_2	357..380	CDD:290200	14/22 (64%)
		C2H2 Zn finger	373..393	CDD:275368	7/19 (37%)
		zf-C2H2	399..421	CDD:278523	9/21 (43%)
		C2H2 Zn finger	401..421	CDD:275368	8/19 (42%)
		zf-H2C2_2	413..438	CDD:290200	13/26 (50%)
		C2H2 Zn finger	429..449	CDD:275368	7/21 (33%)
		zf-H2C2_2	445..466	CDD:290200	1/3 (33%)
		C2H2 Zn finger	457..477	CDD:275368
		zf-H2C2_2	469..494	CDD:290200
		C2H2 Zn finger	485..505	CDD:275368
		zf-H2C2_2	498..520	CDD:290200
		C2H2 Zn finger	513..533	CDD:275368
		zf-H2C2_2	525..550	CDD:290200
		C2H2 Zn finger	541..561	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	605..627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910