DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and znf668

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001012507.1	Gene:	znf668 / 797423	ZFINID:	ZDB-GENE-041001-46	Length:	643	Species:	Danio rerio

Alignment Length:	710	Identity:	172/710 - (24%)
Similarity:	248/710 - (34%)	Gaps:	232/710 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SPSPARTSPTNGVQNL--------GAGAQLPPAQVTDFSISKILGKERKSAQD--TSTNILDLSK 63
            :|.|..:.|:..:.|:        |.|.  ||..:..|..|        |.|:  ||.:.|...|
Zfish    16 TPPPYESEPSKELDNVPEQATRRRGKGR--PPKSLHTFKCS--------SCQEVFTSPSALQSHK 70

  Fly    64 SSSNSIRSPQALGGLAIPSTPYASGAYSMLPPDLVAMANATKFY---AQFFPHLLPAYAAAAAAA 125
            .|.:.....|          .|..|             ..||.:   ||...|
Zfish    71 LSVHGKDKQQ----------QYTCG-------------KCTKMFSTRAQLSKH------------ 100

  Fly   126 GLSTPPTSPYQTHQHQQHLPNQQKRFFAPYVINGSVPPPPPLQQQQQPLIRTKSTACTRPDCPE- 189
            ..|..|..|:|..|.|:                 :...|..|:...:.....|...|.  ||.:
Zfish   101 QRSHSPQRPFQCLQCQK-----------------AYKTPTELRNHSRSHTGEKPFVCL--DCGKA 146

  Fly   190 -----CLDYYQRLQTGGYKQTAPLISPAASSVS-------SSTGSIRPVRDLIMSATGGAASTNI 242
                 ||..:....:|....:.||.|.:..::|       |.||. :|    ...|..|.:..:.
Zfish   147 FMQAICLRIHMTQHSGERPHSCPLCSKSYPTLSKLKVHQRSHTGE-KP----YFCAECGKSFADP 206

  Fly   243 SLTTVTNLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGGYNATSAEEISYKCRICEKVF 307
            |:       ....:...:|..|     ......|.....:..:..:..:...|..|.|..|.|.|
Zfish   207 SV-------YRKHRRNHLGHRP-----YSCAQCGKTYTELKDLKNHERSHTGEKPYLCSDCGKAF 259

  Fly   308 GCSETLQAHEKTH-KSPRYECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLS 371
            ..|.:|..|.:.| ||..|:|..|||||:||.:|:.||..|.|.|.|.  ||:|||.|:|.....
Zfish   260 SRSSSLACHLRIHSKSKPYQCEQCGKGFTQLSSYQSHLRTHSGEKPFL--CPQCGKMFSDPSSFR 322

  Fly   372 SHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGE 436
            .|.:.|:..|.|.|..|.|.|.|.....:|.|:|:|.:|:||..|.|.|.....|::||..|||.
Zfish   323 RHQRAHQGFKPYPCDKCTKRFRQPADLAVHQRVHSGQRPYKCQRCDKAFVASWDLRRHMLVHSGL 387

  Fly   437 KPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFT-----KKH---HL----------- 482
            :|:.|:.|||||.:||::..|.|:|||.:|:.|.||.|:|.     :||   ||
Zfish   388 RPFACTECGKSFTERSSLNKHRRVHSGERPYKCQLCFKSFVVSSSLRKHERTHLSERPIQVHVTP 452

  Fly   483 ----------------------------KTHLNYHT------------GCKPYVC---------- 497
                                        :.|.:.||            ...|:||
Zfish   453 ESASVFPGTLPQFSCSHCDMIFGTWEEVQAHTSLHTISPPSDPSVLAVPVSPHVCVTCQEEFVNL 517

  Fly   498 ------------PHPN----CNQAFTQSSNMRTHAKKCQYRPLDGLTVTSSALP----VPGK--- 539
                        |.|:    |.:.|...:.:|.|.:           :.||..|    |.||
Zfish   518 ADLQAHEKLHPKPRPHICDQCGKGFLNKAGLRKHQR-----------IHSSNRPHSCNVCGKAFL 571

  Fly   540 ------------QQTGPPPTLAMA-MAQTFQMPPPPGVLTP-GSGPSQ-----PPSQQTL 580
                        :.|...|:|... ||.|..:|.||...:| ||.|:.     |.:.||:
Zfish   572 FAAYLRKHLRTHRDTESSPSLPQTDMAHTQPLPSPPSAASPSGSEPTAISLTVPVTFQTI 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	84/271 (31%)
		C2H2 Zn finger	327..347	CDD:275368	11/19 (58%)
		zf-C2H2	356..377	CDD:278523	8/20 (40%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	8/24 (33%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	10/24 (42%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..449	CDD:290200	12/22 (55%)
		zf-C2H2	439..461	CDD:278523	10/21 (48%)
		C2H2 Zn finger	441..461	CDD:275368	10/19 (53%)
		zf-C2H2	467..489	CDD:278523	10/68 (15%)
		C2H2 Zn finger	469..489	CDD:275368	10/66 (15%)
		C2H2 Zn finger	497..515	CDD:275368	6/43 (14%)
znf668	NP_001012507.1	C2H2 Zn finger	53..74	CDD:275368	8/28 (29%)
		COG5048	<55..263	CDD:227381	50/278 (18%)
		C2H2 Zn finger	84..104	CDD:275368	6/44 (14%)
		C2H2 Zn finger	112..132	CDD:275368	4/36 (11%)
		zf-H2C2_2	124..147	CDD:290200	5/24 (21%)
		C2H2 Zn finger	140..160	CDD:275368	5/21 (24%)
		COG5048	164..540	CDD:227381	107/394 (27%)
		C2H2 Zn finger	168..188	CDD:275368	4/19 (21%)
		zf-H2C2_2	181..204	CDD:290200	6/27 (22%)
		C2H2 Zn finger	224..244	CDD:275368	1/19 (5%)
		zf-H2C2_2	236..261	CDD:290200	6/24 (25%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		C2H2 Zn finger	280..300	CDD:275368	11/19 (58%)
		zf-H2C2_2	292..316	CDD:290200	12/25 (48%)
		COG4049	297..353	CDD:226535	21/57 (37%)
		C2H2 Zn finger	308..328	CDD:275368	8/19 (42%)
		C2H2 Zn finger	336..356	CDD:275368	7/19 (37%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		zf-H2C2_2	376..400	CDD:290200	12/23 (52%)
		C2H2 Zn finger	392..412	CDD:275368	10/19 (53%)
		zf-H2C2_2	404..428	CDD:290200	10/23 (43%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..487	CDD:275368	1/19 (5%)
		C2H2 Zn finger	507..527	CDD:275368	1/19 (5%)
		C2H2 Zn finger	535..555	CDD:275368	4/30 (13%)
		C2H2 Zn finger	563..583	CDD:275368	3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910