DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG15269 and MZF1

DIOPT Version :9

Sequence 1:NP_609739.2 Gene:CG15269 / 34887 FlyBaseID:FBgn0028878 Length:587 Species:Drosophila melanogaster
Sequence 2:XP_005259261.1 Gene:MZF1 / 7593 HGNCID:13108 Length:775 Species:Homo sapiens


Alignment Length:645 Identity:174/645 - (26%)
Similarity:242/645 - (37%) Gaps:189/645 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 LPPDLVAMANATKFYAQFFPHLLPA--YAAAAAAAGLSTPPTSP--YQTHQHQ------------ 141
            |||::.|.....:          |.  ..|||...||...|..|  :.|.|.|            
Human   137 LPPEIQARVQGQR----------PGSPEEAAALVDGLRREPGGPRRWVTVQVQGQEVLSEKMEPS 191

  Fly   142 --QHLPNQQKRFFAPYVINGSVPPPPPLQQQQQPL----------------IRTKSTACTRPDCP 188
              |.||..:.....|      .|..||...|:.||                :.:...|.|:...|
Human   192 SFQPLPETEPPTPEP------GPKTPPRTMQESPLGLQVKEESEVTEDSDFLESGPLAATQESVP 250

  Fly   189 ECL------------DYYQRLQTG-------------GYKQTAPLISPA----ASSVSSSTGSIR 224
            ..|            ..:...:||             .:::...:.||.    ..|:|:..||:.
Human   251 TLLPEEAQRCGTVLDQIFPHSKTGPEGPSWREHPRALWHEEAGGIFSPGFALQLGSISAGPGSVS 315

  Fly   225 P----VRDLIM----------SATGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTAV 275
            |    ..||.|          |..||.|...:..:.:.:....:.:....|:.|    .||||..
Human   316 PHLHVPWDLGMAGLSGQIQSPSREGGFAHALLLPSDLRSEQDPTDEDPCRGVGP----ALITTRW 376

  Fly   276 GSNSGAI-------GGI--GGYNATSAEEISYKCRICEKVFG-------------------CSET 312
            .|..|..       ||:  ||           :|.:|.|||.                   |||.
Human   377 RSPRGRSRGRPSTGGGVVRGG-----------RCDVCGKVFSQRSNLLRHQKIHTGERPFVCSEC 430

  Fly   313 ---------LQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDK 367
                     |..|:.||...| :.|.|||:||.:....:.|..||.|.:.|  .|.|||::|..:
Human   431 GRSFSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEEHRRVHTGEQPF--RCAECGQSFRQR 493

  Fly   368 GYLSSHLKIHRNRK-----------------EYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNE 415
            ..|..|.:||.:..                 .:.|..|.:||.:|.....|..:|||.|...|.|
Human   494 SNLLQHQRIHGDPPGPGAKPPAPPGAPEPPGPFPCSECRESFARRAVLLEHQAVHTGDKSFGCVE 558

  Fly   416 CGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKH 480
            ||:||.|:.:|.||.|.||||:|:.|:.||:||..|||:|.|.|:|:|.:||:|..|.|||.::.
Human   559 CGERFGRRSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQHRRIHTGERPFACAECGKAFRQRP 623

  Fly   481 HLKTHLNYHTGCKPYVCPHPNCNQAFTQ----SSNMRTHAKKCQYRPLD-GLTVTS-SALPVPGK 539
            .|..||..|||.||:.|  |.|.|.|:|    :.:.|||..:..|...: ||..|. |.|....:
Human   624 TLTQHLRVHTGEKPFAC--PECGQRFSQRLKLTRHQRTHTGEKPYHCGECGLGFTQVSRLTEHQR 686

  Fly   540 QQTGPPPTLAMAMAQTFQMPPPPGVLT------PGSGPSQPP-------SQQTLLSNLRT 586
            ..||..|.......|:|:.   ...||      .|..|...|       .:.||..:|||
Human   687 IHTGERPFACPECGQSFRQ---HANLTQHRRIHTGERPYACPECGKAFRQRPTLTQHLRT 743

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15269NP_609739.2 C2H2 Zn finger 300..320 CDD:275368 10/47 (21%)
COG5048 <316..502 CDD:227381 80/203 (39%)
C2H2 Zn finger 327..347 CDD:275368 7/19 (37%)
zf-C2H2 356..377 CDD:278523 7/20 (35%)
C2H2 Zn finger 357..377 CDD:275368 7/19 (37%)
zf-H2C2_2 369..394 CDD:290200 8/41 (20%)
C2H2 Zn finger 385..405 CDD:275368 6/19 (32%)
zf-H2C2_2 397..422 CDD:290200 11/24 (46%)
C2H2 Zn finger 413..433 CDD:275368 11/19 (58%)
zf-H2C2_2 426..449 CDD:290200 13/22 (59%)
zf-C2H2 439..461 CDD:278523 11/21 (52%)
C2H2 Zn finger 441..461 CDD:275368 11/19 (58%)
zf-C2H2 467..489 CDD:278523 9/21 (43%)
C2H2 Zn finger 469..489 CDD:275368 8/19 (42%)
C2H2 Zn finger 497..515 CDD:275368 7/21 (33%)
MZF1XP_005259261.1 SCAN 81..193 CDD:128708 15/65 (23%)
COG5048 399..757 CDD:227381 117/352 (33%)
C2H2 Zn finger 399..419 CDD:275368 5/19 (26%)
C2H2 Zn finger 427..447 CDD:275368 5/19 (26%)
C2H2 Zn finger 455..475 CDD:275368 7/19 (37%)
C2H2 Zn finger 483..503 CDD:275370 7/19 (37%)
C2H2 Zn finger 528..548 CDD:275368 6/19 (32%)
C2H2 Zn finger 556..576 CDD:275368 11/19 (58%)
C2H2 Zn finger 584..604 CDD:275368 11/19 (58%)
C2H2 Zn finger 612..632 CDD:275368 8/19 (42%)
C2H2 Zn finger 640..660 CDD:275368 7/21 (33%)
C2H2 Zn finger 668..688 CDD:275368 5/19 (26%)
C2H2 Zn finger 696..716 CDD:275368 4/22 (18%)
C2H2 Zn finger 724..744 CDD:275368 6/20 (30%)
C2H2 Zn finger 752..772 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24384
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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