DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF35

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_003411.3	Gene:	ZNF35 / 7584	HGNCID:	13099	Length:	527	Species:	Homo sapiens

Alignment Length:	406	Identity:	126/406 - (31%)
Similarity:	175/406 - (43%)	Gaps:	97/406 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 HLP-------NQQ-KRFFAPYVINGSVPPPPPLQQQQQPLIRTKSTACTRPDCPEC--------- 190
            |||       ||: |:....|.:|......|..|..|:|.           .|..|
Human   183 HLPESFKEEENQKCKKSGGKYSLNSGAVKNPKTQLGQKPF-----------TCSVCGKGFSQSAN 236

  Fly   191 LDYYQRLQTG-----------GYKQTAPLISPAASSVSSSTGSIRPVRDLIMSATGGAASTNISL 244
            |..:||:.||           .:.|:|.|:    ......||.    :..:.|..|.|.:.:.:|
Human   237 LVVHQRIHTGEKPFECHECGKAFIQSANLV----VHQRIHTGQ----KPYVCSKCGKAFTQSSNL 293

  Fly   245 TTVTNLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGGYNATSAEEISYKCRICEKVFGC 309
            |  .:..::|::.|                                       :||..|||.|..
Human   294 T--VHQKIHSLEKT---------------------------------------FKCNECEKAFSY 317

  Fly   310 SETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSH 373
            |..|..|:|.|.:.: |||.:|||.|::..|...|..:|.|.|.||  |.:|||.|.....|..|
Human   318 SSQLARHQKVHITEKCYECNECGKTFTRSSNLIVHQRIHTGEKPFA--CNDCGKAFTQSANLIVH 380

  Fly   374 LKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKP 438
            .:.|...|.|||..|.|:|:......:|.||||..||:.|:||||.||:...|..|.|.|||:.|
Human   381 QRSHTGEKPYECKECGKAFSCFSHLIVHQRIHTAEKPYDCSECGKAFSQLSCLIVHQRIHSGDLP 445

  Fly   439 YQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCN 503
            |.|:.|||:|...|.:.:|.|:|:|.||::|..|.|||.::..|..|...|||.|||.|  ..|.
Human   446 YVCNECGKAFTCSSYLLIHQRIHNGEKPYTCNECGKAFRQRSSLTVHQRTHTGEKPYEC--EKCG 508

  Fly   504 QAFTQSSNM----RTH 515
            .||..:|::    |||
Human   509 AAFISNSHLMRHHRTH 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	9/19 (47%)
		COG5048	<316..502	CDD:227381	80/186 (43%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		zf-C2H2	356..377	CDD:278523	7/20 (35%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	13/24 (54%)
		C2H2 Zn finger	413..433	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..449	CDD:290200	12/22 (55%)
		zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	7/21 (33%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368	6/21 (29%)
ZNF35	NP_003411.3	Globular domain	9..221		11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..38
		COG5048	<214..369	CDD:227381	49/216 (23%)
		C2H2 Zn finger	224..244	CDD:275368	5/19 (26%)
		C2H2 Zn finger	252..272	CDD:275368	3/23 (13%)
		C2H2 Zn finger	280..300	CDD:275368	5/21 (24%)
		C2H2 Zn finger	308..328	CDD:275368	9/19 (47%)
		C2H2 Zn finger	336..356	CDD:275368	7/19 (37%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		COG5048	372..>449	CDD:227381	32/76 (42%)
		C2H2 Zn finger	392..412	CDD:275368	6/19 (32%)
		C2H2 Zn finger	420..440	CDD:275368	10/19 (53%)
		C2H2 Zn finger	448..468	CDD:275368	8/19 (42%)
		zf-H2C2_2	460..485	CDD:316026	11/24 (46%)
		zf-C2H2	474..496	CDD:306579	7/21 (33%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		zf-H2C2_2	488..513	CDD:316026	12/26 (46%)
		C2H2 Zn finger	504..524	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910