DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and PRDM1

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_011534364.1	Gene:	PRDM1 / 639	HGNCID:	9346	Length:	839	Species:	Homo sapiens

Alignment Length:	522	Identity:	133/522 - (25%)
Similarity:	186/522 - (35%)	Gaps:	170/522 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SPSPARTSPTNGVQNLGAGAQLPPAQVTDFSISKILGKERKSAQDTSTNILDLSKSSSNSIRSPQ 73
            ||.|:.|:|:            |.|               :|:.|.|     |..||.:|  ||
Human   341 SPIPSSTTPS------------PSA---------------RSSPDQS-----LKSSSPHS--SP- 370

  Fly    74 ALGGLAIPSTP----------YASGAYSM--------------LPPDLVAMANATKFYAQFFPHL 114
              |....|..|          |.:.:|..              |||..:...||  .|.:|   |
Human   371 --GNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNA--HYPKF---L 428

  Fly   115 LPAY-------AAAAAAAGLST----PPTSPYQTHQHQQHLPNQQKRFFAPYVINGSVPPPPPLQ 168
            ||.|       :|.::..|::.    |...|                .::..:..||:|
Human   429 LPPYGMNCNGLSAVSSMNGINNFGLFPRLCP----------------VYSNLLGGGSLP------ 471

  Fly   169 QQQQPLIRTKSTACTRPDCPECLDYYQRLQTGGYKQTAPLISPAASSVSSSTGSIRPVRDLIMSA 233
               .|::...|...:.|.     |..:||....:.:  .::.||..|..|.||:...::|...|.
Human   472 ---HPMLNPTSLPSSLPS-----DGARRLLQPEHPR--EVLVPAPHSAFSFTGAAASMKDKACSP 526

  Fly   234 TGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGI-GGYNATSAEEIS 297
            |.|:.:...:.|           |..| :.||.|...:  |..|:..|:..| ...|.|..:.:.
Human   527 TSGSPTAGTAAT-----------AEHV-VQPKATSAAM--AAPSSDEAMNLIKNKRNMTGYKTLP 577

  Fly   298 YKCRICEKVFGCSETLQAHEKTHKSPRYECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGK 362
            |..:                |.:...:|||..|.|.|.||.|.|.||.||.|.:.|
Human   578 YPLK----------------KQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPF--------- 617

  Fly   363 TFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLK 427
                                 :|..|.|.|.|......|..:|||.|||:|..|.||||....||
Human   618 ---------------------KCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLK 661

  Fly   428 QHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGC 492
            .|:|.|||||||||.||...|....::.||.|||:..:|..|..|.|.:.....||.||..:...
Human   662 THLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRERPHKCSQCHKNYIHLCSLKVHLKGNCAA 726

  Fly   493 KP 494
            .|
Human   727 AP 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	1/19 (5%)
		COG5048	<316..502	CDD:227381	65/179 (36%)
		C2H2 Zn finger	327..347	CDD:275368	10/19 (53%)
		zf-C2H2	356..377	CDD:278523	0/20 (0%)
		C2H2 Zn finger	357..377	CDD:275368	0/19 (0%)
		zf-H2C2_2	369..394	CDD:290200	4/24 (17%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..433	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..449	CDD:290200	15/22 (68%)
		zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-C2H2	467..489	CDD:278523	7/21 (33%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368
PRDM1	XP_011534364.1	SET	114..220	CDD:214614
		COG5048	<584..702	CDD:227381	56/147 (38%)
		zf-C2H2	589..611	CDD:278523	12/21 (57%)
		C2H2 Zn finger	591..611	CDD:275368	10/19 (53%)
		zf-H2C2_2	603..628	CDD:290200	12/54 (22%)
		C2H2 Zn finger	619..639	CDD:275368	6/19 (32%)
		zf-H2C2_2	631..656	CDD:290200	12/24 (50%)
		C2H2 Zn finger	647..667	CDD:275368	10/19 (53%)
		zf-H2C2_2	659..684	CDD:290200	16/24 (67%)
		C2H2 Zn finger	675..695	CDD:275368	7/19 (37%)
		zf-H2C2_2	687..708	CDD:290200	8/20 (40%)
		C2H2 Zn finger	703..721	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910