DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and Zfp987

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001033015.1	Gene:	Zfp987 / 626316	MGIID:	3702694	Length:	633	Species:	Mus musculus

Alignment Length:	461	Identity:	131/461 - (28%)
Similarity:	192/461 - (41%)	Gaps:	142/461 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SPYQTHQHQQHLPNQQKRFFAPYVINGSVPPPPPLQQQQ------QPLIRTKSTACTRPD----- 186
            :||:..:..::|..::.                 ||.||      :|...:||..|....
Mouse   182 NPYKCSEFHKYLTQREN-----------------LQSQQRIYHGKKPYKSSKSDKCFTHQIHLSI 229

  Fly   187 ------------CPEC---------LDYYQRLQTGGYKQTAPLISPAASSVSSSTGSIRPVRDLI 230
                        |.||         |..:||:.||.                      :|.:
Mouse   230 HQEIHTEEKIYKCSECDKCFKNKFNLTMHQRIHTGE----------------------KPYK--- 269

  Fly   231 MSATGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGGYNATSAEE 295
                  .:..:...|..:|||::  |....|..|
Mouse   270 ------CSECDKCFTKQSNLSIH--QRIHTGEKP------------------------------- 295

  Fly   296 ISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPE 359
              |||..|:|.|.....|..|::.|...: |:|::|||.|::..:.:.|..:|.|.|.:  :|.|
Mouse   296 --YKCSECDKCFTQESYLSIHQRIHTGEKPYKCSECGKCFTEKSSLRIHQRIHTGEKPY--KCSE 356

  Fly   360 CGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKM 424
            |.|.|..:.:||.|.:||...|.|:|..|.|.|.|:...::|.|||||.||:||:||||.|:.|.
Mouse   357 CDKCFTQQSHLSIHQRIHTGEKPYKCSECDKCFTQQSNLSIHQRIHTGEKPYKCSECGKCFTEKS 421

  Fly   425 LLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYH 489
            .|:.|.|.|:|||||:||.|||.|.::|::.:|.|:|:|.||:.|..|.|.||:|..|:.|...|
Mouse   422 SLRIHQRIHTGEKPYKCSECGKCFTEKSSLRIHQRIHTGEKPYKCNECGKCFTEKSSLRIHQRIH 486

  Fly   490 TGCKPYVCPHPNCNQAFTQSSNMRTHAK--------------KCQYRPLDGLTVTSSALPVPGKQ 540
            ||.|||.|  ..|.:.||..|::|.|.|              ||..:|        |.|.:..:.
Mouse   487 TGEKPYKC--SECGKCFTVKSSLRIHQKIHTGEKPYKCSECDKCFTKP--------SHLSIHQRI 541

  Fly   541 QTGPPP 546
            .||..|
Mouse   542 HTGEKP 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		COG5048	<316..502	CDD:227381	82/186 (44%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-C2H2	356..377	CDD:278523	8/20 (40%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	11/24 (46%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	15/24 (63%)
		C2H2 Zn finger	413..433	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..449	CDD:290200	14/22 (64%)
		zf-C2H2	439..461	CDD:278523	10/21 (48%)
		C2H2 Zn finger	441..461	CDD:275368	9/19 (47%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	6/17 (35%)
Zfp987	NP_001033015.1	KRAB	13..>55	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	186..206	CDD:275368	5/36 (14%)
		C2H2 Zn finger	218..234	CDD:275368	1/15 (7%)
		COG5048	238..611	CDD:227381	120/388 (31%)
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		zf-H2C2_2	254..278	CDD:290200	6/54 (11%)
		C2H2 Zn finger	270..290	CDD:275368	5/21 (24%)
		zf-H2C2_2	282..307	CDD:290200	12/59 (20%)
		C2H2 Zn finger	298..318	CDD:275368	6/19 (32%)
		zf-H2C2_2	310..334	CDD:290200	8/23 (35%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		zf-H2C2_2	338..363	CDD:290200	9/26 (35%)
		C2H2 Zn finger	354..374	CDD:275368	8/19 (42%)
		zf-H2C2_2	366..391	CDD:290200	11/24 (46%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..418	CDD:290200	14/23 (61%)
		C2H2 Zn finger	410..430	CDD:275368	10/19 (53%)
		zf-H2C2_2	422..446	CDD:290200	14/23 (61%)
		C2H2 Zn finger	438..458	CDD:275368	9/19 (47%)
		zf-H2C2_2	450..474	CDD:290200	9/23 (39%)
		C2H2 Zn finger	466..486	CDD:275368	8/19 (42%)
		zf-H2C2_2	478..502	CDD:290200	10/25 (40%)
		C2H2 Zn finger	494..514	CDD:275368	8/21 (38%)
		zf-H2C2_2	506..530	CDD:290200	5/23 (22%)
		C2H2 Zn finger	522..542	CDD:275368	5/27 (19%)
		zf-H2C2_2	534..558	CDD:290200	4/14 (29%)
		C2H2 Zn finger	550..570	CDD:275368
		zf-H2C2_2	563..587	CDD:290200
		C2H2 Zn finger	578..598	CDD:275368
		C2H2 Zn finger	606..626	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910