DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and PLAGL2

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_002648.1	Gene:	PLAGL2 / 5326	HGNCID:	9047	Length:	496	Species:	Homo sapiens

Alignment Length:	312	Identity:	77/312 - (24%)
Similarity:	122/312 - (39%)	Gaps:	61/312 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 NATSAEEISYK-----------------CRICEKVFGCSETLQAHEKTHKSPR-YECAD--CGKG 333
            :|...||:.:|                 |.|....|...|.|:.|.......| |.|..  |||.
Human    14 DAKQEEEVGWKLVPRPRGREAESQVKCQCEISGTPFSNGEKLRPHSLPQPEQRPYSCPQLHCGKA 78

  Fly   334 FSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSHLKIH-RNRKEYECPYCPKSFNQRVA 397
            |:.......|::.|...|..  :|..|.|.|:.|.:|.:||:.| .|::...|..|.|::|.::.
Human    79 FASKYKLYRHMATHSAQKPH--QCMYCDKMFHRKDHLRNHLQTHDPNKEALHCSECGKNYNTKLG 141

  Fly   398 FNMHVRIHTGVKPH-KCNECGKRFSRKMLLKQHMRTHS-------GEKPYQCSVCGKSFADRSNM 454
            :..|:.:|...... .|..|.:.|.....|.:|::.||       .||.:.|..|.:.|..|.::
Human   142 YRRHLAMHAASSGDLSCKVCLQTFESTQALLEHLKAHSRRVAGGAKEKKHPCDHCDRRFYTRKDV 206

  Fly   455 TLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAK-- 517
            ..|..:|:|.|.|.|..|.:.|.:|.||..|:.                         ::|::
Human   207 RRHLVVHTGRKDFLCQYCAQRFGRKDHLTRHVK-------------------------KSHSQEL 246

  Fly   518 -KCQYRPLDGLTVTSSALPVPGKQQTGPPPTLAMAMAQTFQMPPPPGVLTPG 568
             |.:..|:|.|.:.|.:..|..|::..  |.|.||..........||:|..|
Human   247 LKIKTEPVDMLGLLSCSSTVSVKEELS--PVLCMASRDVMGTKAFPGMLPMG 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		COG5048	<316..502	CDD:227381	52/197 (26%)
		C2H2 Zn finger	327..347	CDD:275368	6/21 (29%)
		zf-C2H2	356..377	CDD:278523	8/20 (40%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	8/25 (32%)
		C2H2 Zn finger	385..405	CDD:275368	5/19 (26%)
		zf-H2C2_2	397..422	CDD:290200	5/25 (20%)
		C2H2 Zn finger	413..433	CDD:275368	5/19 (26%)
		zf-H2C2_2	426..449	CDD:290200	8/29 (28%)
		zf-C2H2	439..461	CDD:278523	5/21 (24%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368	0/17 (0%)
PLAGL2	NP_002648.1	C2H2 Zn finger	70..92	CDD:275368	6/21 (29%)
		zf-H2C2_2	85..109	CDD:404364	7/25 (28%)
		C2H2 Zn finger	100..120	CDD:275368	8/19 (42%)
		C2H2 Zn finger	129..149	CDD:275368	5/19 (26%)
		C2H2 Zn finger	158..178	CDD:275368	5/19 (26%)
		C2H2 Zn finger	193..213	CDD:275368	5/19 (26%)
		C2H2 Zn finger	221..239	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910