DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and PLAG1

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001108106.1	Gene:	PLAG1 / 5324	HGNCID:	9045	Length:	500	Species:	Homo sapiens

Alignment Length:	300	Identity:	79/300 - (26%)
Similarity:	128/300 - (42%)	Gaps:	54/300 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 SYKCRICEKVFGCSETLQAHEKTHKSPR-YEC--ADCGKGFSQLRNYKYHLSVHRGTKEFAAECP 358
            ::.|::|:|.|...|.|:.|..:|...| |:|  .||.|.|......:.|::.|  :.|...:|.
Human    33 NFPCQLCDKAFNSVEKLKVHSYSHTGERPYKCIQQDCTKAFVSKYKLQRHMATH--SPEKTHKCN 95

  Fly   359 ECGKTFNDKGYLSSHLKIH-RNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPH-KCNECGKRFS 421
            .|.|.|:.|.:|.:||..| .|::.::|..|.|::|.::.|..|:.:|...... .|..|.:.|.
Human    96 YCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKNYNTKLGFKRHLALHAATSGDLTCKVCLQTFE 160

  Fly   422 RKMLLKQHMRTHSG-------EKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKK 479
            ...:|.:|:::|:|       ||.:||..|.:.|..|.::..|..:|:|.|.|.|..|.:.|.:|
Human   161 STGVLLEHLKSHAGKSSGGVKEKKHQCEHCDRRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRK 225

  Fly   480 HHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAKKCQYRPLDGLTVTSSALPVPGKQQTGP 544
            .||..|:.                    :|.|.  ...|.:..|:|.|...:..:.||.|.:..|
Human   226 DHLTRHMK--------------------KSHNQ--ELLKVKTEPVDFLDPFTCNVSVPIKDELLP 268

  Fly   545 PPTLAMAMAQTFQMPPPPGVLTPGSGPSQPPSQQTLLSNL 584
            ..:|                  |.|.....|...||..||
Human   269 VMSL------------------PSSELLSKPFTNTLQLNL 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	55/197 (28%)
		C2H2 Zn finger	327..347	CDD:275368	6/21 (29%)
		zf-C2H2	356..377	CDD:278523	8/20 (40%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	8/25 (32%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	6/25 (24%)
		C2H2 Zn finger	413..433	CDD:275368	5/19 (26%)
		zf-H2C2_2	426..449	CDD:290200	9/29 (31%)
		zf-C2H2	439..461	CDD:278523	6/21 (29%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368	2/17 (12%)
PLAG1	NP_001108106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Interaction with KPNA2. /evidence=ECO:0000269\|PubMed:11882654	2..84		16/50 (32%)
		Nuclear localization signal	22..25
		C2H2 Zn finger	36..56	CDD:275368	7/19 (37%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm	41..242		61/224 (27%)
		SFP1	<58..139	CDD:227516	25/82 (30%)
		C2H2 Zn finger	64..86	CDD:275368	6/21 (29%)
		zf-H2C2_2	79..103	CDD:404364	7/25 (28%)
		C2H2 Zn finger	94..114	CDD:275368	8/19 (42%)
		C2H2 Zn finger	123..143	CDD:275368	6/19 (32%)
		C2H2 Zn finger	152..172	CDD:275368	5/19 (26%)
		C2H2 Zn finger	187..207	CDD:275368	5/19 (26%)
		C2H2 Zn finger	215..233	CDD:275368	7/17 (41%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction	243..500		14/65 (22%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity	243..384		14/65 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..388
		Massively activates transcription	385..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910