DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG15269 and ZNF727

DIOPT Version :9

Sequence 1:NP_609739.2 Gene:CG15269 / 34887 FlyBaseID:FBgn0028878 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_001152994.1 Gene:ZNF727 / 442319 HGNCID:22785 Length:499 Species:Homo sapiens


Alignment Length:357 Identity:122/357 - (34%)
Similarity:158/357 - (44%) Gaps:89/357 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   293 AEEISYKCRICEKVFGCSE-TLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAA 355
            :.|..|||..|.|....|: |:|  ::.|.:.| |:|.:|||...:..|...|..||.|.|.:  
Human   168 SREKCYKCEECGKDCRLSDFTIQ--KRIHTADRSYKCEECGKACKKFSNLTEHNRVHTGKKPY-- 228

  Fly   356 ECPECGKTF--------------NDKGY--------------LSSHLKIHRNRKEYECPYCPKSF 392
            :|.||||||              .|:.|              |:.|.:||...|.|:|..|.|:|
Human   229 KCEECGKTFTCSSALTKHKRNHTGDRPYKCEECHKAFRCCSDLTKHKRIHTGEKPYKCKECHKAF 293

  Fly   393 NQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLH 457
            ........|.|||||.||:|||||||.|.....|.||.|.|:|||||.|..|||:|...|.:..|
Human   294 RCCSDLTKHKRIHTGEKPYKCNECGKAFMWISALSQHNRIHTGEKPYICEECGKAFTYSSTLISH 358

  Fly   458 HRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAK----- 517
            .|:|..::|:.|..|.|.|.....|..|...|||.|||.|  ..|.::||.|||:..|.:     
Human   359 KRIHMELRPYKCEECGKTFKWFSDLTNHKRIHTGEKPYKC--EECGKSFTCSSNLIKHKRIHMEV 421

  Fly   518 ---KCQ------------------------YRPLD-GLTVT-SSALPVPGKQQTGPPPTLAMAMA 553
               ||:                        |:..: |.|.| ||:|....:..||..||.|..:|
Human   422 RPYKCEECGKTFKWFPDLTNHKRIHTGEKPYKCEECGKTFTCSSSLIKHKRSHTGDRPTSAKNVA 486

  Fly   554 QTFQMPPPPGVLTPGSGPSQPPSQQTLLSNLR 585
            :      |.|    ||        |||| |:|
Human   487 K------PLG----GS--------QTLL-NIR 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15269NP_609739.2 C2H2 Zn finger 300..320 CDD:275368 6/20 (30%)
COG5048 <316..502 CDD:227381 81/214 (38%)
C2H2 Zn finger 327..347 CDD:275368 6/19 (32%)
zf-C2H2 356..377 CDD:278523 11/48 (23%)
C2H2 Zn finger 357..377 CDD:275368 11/47 (23%)
zf-H2C2_2 369..394 CDD:290200 11/38 (29%)
C2H2 Zn finger 385..405 CDD:275368 6/19 (32%)
zf-H2C2_2 397..422 CDD:290200 16/24 (67%)
C2H2 Zn finger 413..433 CDD:275368 11/19 (58%)
zf-H2C2_2 426..449 CDD:290200 14/22 (64%)
zf-C2H2 439..461 CDD:278523 9/21 (43%)
C2H2 Zn finger 441..461 CDD:275368 8/19 (42%)
zf-C2H2 467..489 CDD:278523 6/21 (29%)
C2H2 Zn finger 469..489 CDD:275368 6/19 (32%)
C2H2 Zn finger 497..515 CDD:275368 7/17 (41%)
ZNF727NP_001152994.1 KRAB 4..64 CDD:214630
KRAB 4..43 CDD:279668
C2H2 Zn finger 148..167 CDD:275370
C2H2 Zn finger 175..194 CDD:275368 6/20 (30%)
C2H2 Zn finger 202..222 CDD:275368 6/19 (32%)
zf-H2C2_2 214..239 CDD:290200 13/26 (50%)
COG5048 <226..409 CDD:227381 72/186 (39%)
C2H2 Zn finger 230..250 CDD:275368 7/19 (37%)
zf-H2C2_2 242..267 CDD:290200 2/24 (8%)
C2H2 Zn finger 258..278 CDD:275368 2/19 (11%)
zf-H2C2_2 270..295 CDD:290200 10/24 (42%)
C2H2 Zn finger 286..306 CDD:275368 6/19 (32%)
zf-H2C2_2 298..321 CDD:290200 15/22 (68%)
C2H2 Zn finger 314..334 CDD:275368 11/19 (58%)
zf-H2C2_2 326..351 CDD:290200 15/24 (63%)
C2H2 Zn finger 342..362 CDD:275368 8/19 (42%)
C2H2 Zn finger 370..390 CDD:275368 6/19 (32%)
zf-H2C2_2 382..407 CDD:290200 11/26 (42%)
C2H2 Zn finger 398..418 CDD:275368 8/21 (38%)
C2H2 Zn finger 426..446 CDD:275368 1/19 (5%)
zf-H2C2_2 438..463 CDD:290200 3/24 (13%)
C2H2 Zn finger 454..474 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24384
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

Return to query results.
Submit another query.