DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and Zfp560

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001004190.2	Gene:	Zfp560 / 434377	MGIID:	1915280	Length:	754	Species:	Mus musculus

Alignment Length:	566	Identity:	167/566 - (29%)
Similarity:	226/566 - (39%)	Gaps:	131/566 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 SNSIRSPQALGG--LAIPSTPYASGAYSMLPP---DLVAMANATKF-----YAQFFPHLLPAYAA 120
            ||.|:.|.:..|  |.....|   |.....||   ..:.:.|....     |.|.||......::
Mouse   130 SNEIQLPNSHNGKELCDIKPP---GEIIKEPPCSLTYIGIENTGNIYDCVQYGQLFPVCPKETSS 191

  Fly   121 AAAAAGL-------STPPTSPYQTHQHQ---------QHLPNQQKRFFAPYVINGSVPPPPPLQQ 169
            |....||       |...::.|||...|         |.:.:.|.....|    |.......|.:
Mouse   192 ADTGPGLRQYGKDFSMIASTAYQTTCVQSKFIESSEFQQVFDSQSSLQRP----GGSHSEDKLSE 252

  Fly   170 QQQ------PLIRTKSTA--CTRP---DCPEC---------LDYYQRLQTG-----------GYK 203
            ..|      |.:....:|  ||..   :|.||         |:.:.|..||           .:.
Mouse   253 SVQCGDTFSPALSHAESAQTCTGKKSYECKECGKSFKYSANLNIHMRTHTGEKPYQCKECGKAFS 317

  Fly   204 QTAPLI---------SPAASSV------SSS---------TGSIRP--VRDLIMSATGGAASTNI 242
            :..||.         .|....|      :||         || |:|  .:|...:.||   .:.:
Mouse   318 RCYPLTQHLKTHTEEKPFECKVCGKCFRNSSCLNDHFRVHTG-IKPYKCKDCGKAFTG---RSGL 378

  Fly   243 SLTTVTNLSLNSVQATAVGMMPKMTGGLIT-----------------TAVGSNSGAIGGIGGYNA 290
            |....|:......:....|.....|.|||.                 .|..|:|..|..:    .
Mouse   379 SKHLPTHTGEKPYECKECGKAFPSTSGLIKHMKSHMGERPFECDHCGKAFASSSTLITHL----R 439

  Fly   291 TSAEEISYKCRICEKVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFA 354
            |...|..::|::|.|.|.||..|:.|.:||...: |.|.:||:.|::..:...||..|.|...|
Mouse   440 THTGEKPFECQVCGKAFTCSSYLRIHMRTHTGEKPYVCKECGRAFTERTSLTKHLRTHTGENPF- 503

  Fly   355 AECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKR 419
             ||..|||.|....||.:|::.|...|.|.|..|.|:|......:.|||||||.|||||.||||.
Mouse   504 -ECNMCGKAFACSSYLHNHIRTHTGEKPYVCKECGKAFTVSSHLSKHVRIHTGEKPHKCEECGKA 567

  Fly   420 FSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKT 484
            |:.:..|.:|:|||:|||||.|..|||:|...|.:..|.|.|:|.||:.|..|.|||....:|..
Mouse   568 FTVRSGLTKHIRTHTGEKPYNCKECGKAFTTSSGLLEHKRSHTGEKPYECDQCGKAFASSSYLIA 632

  Fly   485 HLNYHTGCKPYVCPHPNCNQAFTQSS----NMRTH-------AKKC 519
            ||..|||.||:.|  ..|.:|||.||    :||||       .|:|
Mouse   633 HLRIHTGEKPFEC--NECGKAFTCSSYLHIHMRTHTGEKPYDCKEC 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		COG5048	<316..502	CDD:227381	82/186 (44%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-C2H2	356..377	CDD:278523	9/20 (45%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	17/24 (71%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	426..449	CDD:290200	14/22 (64%)
		zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	9/21 (43%)
Zfp560	NP_001004190.2	KRAB	41..97	CDD:214630
		KRAB	41..80	CDD:279668
		COG5048	276..689	CDD:227381	134/413 (32%)
		zf-C2H2	279..301	CDD:278523	5/21 (24%)
		C2H2 Zn finger	281..301	CDD:275368	5/19 (26%)
		zf-H2C2_2	293..318	CDD:290200	4/24 (17%)
		C2H2 Zn finger	309..329	CDD:275368	2/19 (11%)
		zf-H2C2_2	322..346	CDD:290200	3/23 (13%)
		C2H2 Zn finger	337..357	CDD:275368	3/19 (16%)
		zf-H2C2_2	350..373	CDD:290200	5/23 (22%)
		C2H2 Zn finger	365..385	CDD:275368	4/22 (18%)
		C2H2 Zn finger	393..413	CDD:275368	5/19 (26%)
		zf-H2C2_2	406..430	CDD:290200	3/23 (13%)
		C2H2 Zn finger	421..441	CDD:275368	4/23 (17%)
		zf-H2C2_2	434..458	CDD:290200	7/27 (26%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		zf-H2C2_2	461..485	CDD:290200	8/23 (35%)
		C2H2 Zn finger	477..497	CDD:275368	6/19 (32%)
		zf-H2C2_2	489..514	CDD:290200	11/26 (42%)
		C2H2 Zn finger	505..525	CDD:275368	8/19 (42%)
		zf-H2C2_2	520..541	CDD:290200	7/20 (35%)
		C2H2 Zn finger	533..553	CDD:275368	7/19 (37%)
		zf-H2C2_2	545..569	CDD:290200	16/23 (70%)
		C2H2 Zn finger	561..581	CDD:275368	9/19 (47%)
		zf-H2C2_2	574..598	CDD:290200	15/23 (65%)
		C2H2 Zn finger	589..609	CDD:275368	8/19 (42%)
		zf-H2C2_2	602..626	CDD:290200	11/23 (48%)
		C2H2 Zn finger	617..637	CDD:275368	8/19 (42%)
		zf-H2C2_2	629..654	CDD:290200	12/26 (46%)
		C2H2 Zn finger	645..665	CDD:275368	9/21 (43%)
		zf-H2C2_2	661..681	CDD:290200	6/16 (38%)
		C2H2 Zn finger	673..693	CDD:275368	2/4 (50%)
		C2H2 Zn finger	701..718	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910