DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15269 and topi

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	721	Identity:	149/721 - (20%)
Similarity:	238/721 - (33%)	Gaps:	208/721 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LQRSYDLSPSPARTSPTNGV-----------QNL-------GAGAQLPPAQVTDFSISKILGKER 48
            |.|.:.:.|:.|...||:.|           |.|       |...|....::.||     |....
  Fly    52 LSRFFAVGPAGALPMPTDVVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDF-----LAGVT 111

  Fly    49 KSAQDTSTNILDLSKSSS-----NSIRSPQALGGLAIPSTPYASGAYSMLPPDLVAMANATKFYA 108
            .|...|..::...|:|:|     |.|:.|..|  :...:..:.:.:....|.: ||:....|
  Fly   112 SSKMTTEQSVFHGSRSNSSASTVNRIKCPTCL--VQFDAVAFQNHSCEAKPIE-VAVPQQEK--- 170

  Fly   109 QFFPHLLPAYAAAAAAAGLSTPPTS---------------------------------------- 133
               |||:|  ..:|..|.||.|.:.
  Fly   171 ---PHLVP--TVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNEC 230

  Fly   134 -------------------------PYQTHQHQQHLP----------NQQKR-FFAPYVI--NGS 160
                                     |.||.:....:|          |...| |:.|.|.  :|.
  Fly   231 TMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGL 295

  Fly   161 VPPPPPLQQQQQPLIRTKSTACTRPDCPECLDYYQRLQTG--------GYKQTAPLISPAASSVS 217
            :........:|.|:.:..|...         |:.:.|..|        .:..:....:|....:.
  Fly   296 IHDSEHSTMRQSPMTQVPSNRA---------DFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMF 351

  Fly   218 SS--TGSI----------RPVRDLIMSATGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGL 270
            ||  .||:          ..:.:|::.:....|..... .|..::.:|:.:..::...
  Fly   352 SSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFE-CTACDIQMNTAKEASIHFQ------- 408

  Fly   271 ITTAVGSNSGAIGGIGGYNATSAEEISYKCRICEKVFGCSETLQAHEKTHKSPRYECADCGKGFS 335
             |..:....    .|...|.|.:.  .:.|.:||..|..::.||.|..|
  Fly   409 -TDCIFMRE----AIRSLNVTLSR--YFVCNVCELKFANTDLLQEHRCT---------------- 450

  Fly   336 QLRNYKYHLSVHRGTKEFAAECPECGKTFN-DKGYLSSHLKIHRNRK---------------EYE 384
               ::.|...::...|:....|..|...|. ...:|:...:.|.|:|               :|.
  Fly   451 ---SFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYL 512

  Fly   385 CPYCPKSFNQRVAFNMHVRIHTGVKPHKCNE--CGKRFSRKMLLKQHMR-THSGEKPYQCSVCGK 446
            |..|.||:.|......|:|.|.||||..|.|  |.::|:.:..|..|:| .|:||:||.|.||||
  Fly   513 CDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGK 577

  Fly   447 SFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSN 511
            .|...|....|..:|.|.:.:.|..|.|.|.:...||.|...|||.|||.|..  |.:.|.|..:
  Fly   578 RFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLF--CTKTFRQRGD 640

  Fly   512 MRTHAKKCQYRPLDGLTVTSSALPVPGKQQTGPPPTLAMAMAQTFQMPPPPGVLTPGSGPSQPPS 576
            ...|. :.::..||    .:|.|.:  :.|.....|.|...||:.........:..|:..|..||
  Fly   641 RDKHI-RARHSHLD----ANSRLMM--QMQKFQLETAAAQKAQSHNPEQQDNDVAGGASTSDVPS 698

  Fly   577 QQTLLS 582
            ....:|
  Fly   699 GSGFMS 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	60/204 (29%)
		C2H2 Zn finger	327..347	CDD:275368	1/19 (5%)
		zf-C2H2	356..377	CDD:278523	4/21 (19%)
		C2H2 Zn finger	357..377	CDD:275368	4/20 (20%)
		zf-H2C2_2	369..394	CDD:290200	9/39 (23%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..422	CDD:290200	11/26 (42%)
		C2H2 Zn finger	413..433	CDD:275368	7/22 (32%)
		zf-H2C2_2	426..449	CDD:290200	13/23 (57%)
		zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	7/21 (33%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368	4/17 (24%)
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	0/19 (0%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..453	CDD:275368	8/40 (20%)
		COG5048	<450..647	CDD:227381	63/218 (29%)
		C2H2 Zn finger	469..490	CDD:275368	4/20 (20%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	19/50 (38%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	14/25 (56%)
		C2H2 Zn finger	572..592	CDD:275368	8/19 (42%)
		zf-H2C2_2	585..609	CDD:290200	7/23 (30%)
		zf-C2H2	598..620	CDD:278523	7/21 (33%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	12/26 (46%)
		C2H2 Zn finger	628..646	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910