DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and znf384a

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_005159474.1	Gene:	znf384a / 368610	ZFINID:	ZDB-GENE-030616-498	Length:	596	Species:	Danio rerio

Alignment Length:	581	Identity:	150/581 - (25%)
Similarity:	222/581 - (38%)	Gaps:	198/581 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GVQNLGAGAQL-PPAQVTDFSISKILGKERKSAQDTSTNILDLSKSSSNSIRSPQALGGLAIPST 83
            |.|..|.||.| ||....:.::..:          .||.|:    :::..:.:||  |.|..|
Zfish    90 GAQMTGVGAHLHPPHTSQNITVVPV----------PSTGIM----TAAGLVITPQ--GTLVSP-- 136

  Fly    84 PYASGAYSMLPPDLVAMANATKFYAQFFPHLLPAYAAAAAAAGLSTPPTSPYQTHQHQQHLPNQQ 148
            |.:|.::...||....:.:|          |.|:...|.      .||:....:|..::
Zfish   137 PASSQSFVSGPPTTTMIVSA----------LHPSNTEAV------RPPSLYLHSHYKKE------ 179

  Fly   149 KRFFAPYVINGSVPP----PPPLQQQQQPLIRTKSTACTRPDCPECLDYYQRLQTGGYKQTAPLI 209
                     :||:||    |.|.::.     |.|.:...|                    ..|:.
Zfish   180 ---------DGSIPPAVVMPIPSKRG-----RKKKSMMPR--------------------AGPVS 210

  Fly   210 SPAASSVSSSTGSIRPVRDLIMS--ATGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLIT 272
            :.|.:|.|.:         ||::  |.||..:||
Zfish   211 AHALASGSDA---------LILAHLAAGGQHNTN------------------------------- 235

  Fly   273 TAVGSNSGAIGGIGGYNATSAEE--------ISYKCRICEKVFGCSETLQAHEKTHKSPRYECAD 329
                         ..|:.::.|:        .||:||:|...|.....:|.|.|:|
Zfish   236 -------------DPYDLSNDEDEHQGKDGNKSYRCRMCAVTFFSKSDMQIHAKSH--------- 278

  Fly   330 CGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSHLKIHRNRKEYECPYCPKSFNQ 394
                                |:....:||.|.|:|.:..||:.|::||...|.|.|.||.|:|.|
Zfish   279 --------------------TEAKPHKCPHCSKSFANSSYLAQHIRIHSGAKPYTCSYCQKTFRQ 323

  Fly   395 RVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKPYQCSVCGKSFADRSNMTLHHR 459
            ......|.|.||..|||||..|.|.|:....|.||:|.|||.|||.||.|.|:|...|::..|:|
Zfish   324 LSHLQQHTRNHTEGKPHKCPHCSKSFANSSYLAQHIRIHSGAKPYTCSYCQKTFRQLSHLQQHNR 388

  Fly   460 LHSGIKPFSC--PLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRT-------- 514
            :|:|.:|:.|  |.|.||||:..:|::|...|...|||.| | |||:.:|.::::..
Zfish   389 IHTGDRPYKCVHPGCEKAFTQLSNLQSHRRQHNKDKPYKC-H-NCNRGYTDATSLEVHLTTHTVK 451

  Fly   515 HAK--KCQYRPLDGL---TVTSSALPVPGKQQTGPPPTLAMAMAQTFQMPPPPGVLTPGSG 570
            |||  .|      ||   :.||....:...|:..|.| |.:|.|...|....||   .|||
Zfish   452 HAKLYSC------GLCNRSYTSETYLMKHMQKHNPDP-LTVAAAVAAQQAQNPG---QGSG 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	70/187 (37%)
		C2H2 Zn finger	327..347	CDD:275368	0/19 (0%)
		zf-C2H2	356..377	CDD:278523	8/20 (40%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	12/24 (50%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..433	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..449	CDD:290200	14/22 (64%)
		zf-C2H2	439..461	CDD:278523	9/21 (43%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-C2H2	467..489	CDD:278523	9/23 (39%)
		C2H2 Zn finger	469..489	CDD:275368	9/21 (43%)
		C2H2 Zn finger	497..515	CDD:275368	6/25 (24%)
znf384a	XP_005159474.1	C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		zf-H2C2_2	270..295	CDD:290200	10/53 (19%)
		zf-C2H2_8	283..363	CDD:292531	34/79 (43%)
		zf-C2H2	284..306	CDD:278523	8/21 (38%)
		C2H2 Zn finger	286..306	CDD:275368	8/19 (42%)
		COG5048	<310..478	CDD:227381	69/175 (39%)
		zf-C2H2	312..334	CDD:278523	9/21 (43%)
		C2H2 Zn finger	314..334	CDD:275368	8/19 (42%)
		zf-H2C2_2	326..351	CDD:290200	12/24 (50%)
		C2H2 Zn finger	342..362	CDD:275368	8/19 (42%)
		zf-H2C2_2	354..379	CDD:290200	15/24 (63%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
		zf-H2C2_2	382..409	CDD:290200	11/26 (42%)
		C2H2 Zn finger	398..420	CDD:275368	9/21 (43%)
		C2H2 Zn finger	428..448	CDD:275368	6/21 (29%)
		C2H2 Zn finger	458..478	CDD:275368	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910