DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and Zfp143

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001012169.2	Gene:	Zfp143 / 361627	RGDID:	1305662	Length:	638	Species:	Rattus norvegicus

Alignment Length:	381	Identity:	111/381 - (29%)
Similarity:	166/381 - (43%)	Gaps:	53/381 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 RPVRDLIMSATGGAASTNISLTTVTNLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGGY 288
            :|...|.:.|.|..|..:....|:...::::::..|..:....:.|:.:|      |.||
  Rat   153 QPDTILAIQADGTVAGLHTGDATIDPDTISALEQYAAKVSIDGSEGVTST------GLIG----- 206

  Fly   289 NATSAEEISYKCRICEKVFGCSETLQAHEKTHKSPRYECADCGKGFSQLRNYKYHLSVHRGTKEF 353
                ..|...|.:|..:......|.::.:...|:.|.:...|||.::...:.|.|...|.|.:.:
  Rat   207 ----ENEQEKKMQIVLQGHATRVTPKSQQSGEKAFRCKYDGCGKLYTTAHHLKVHERSHTGDRPY 267

  Fly   354 AAECPECGKTFNDKGY-LSSHLKIHRNRKEYEC--PYCPKSFNQRVAFNMHVRIHTGVKPHKC-- 413
            ..|...|||.| ..|| |.||.:.|...|.|.|  ..|.|||........|:|.|||.:|.||
  Rat   268 QCEHSGCGKAF-ATGYGLKSHFRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCPI 331

  Fly   414 NECGKRFSRKMLLKQHMRTHSGEKPYQCSV--CGKSFADRSNMTLHHRLHSGIKPFSC--PLCPK 474
            ..||:.|:...:.|.|:|||:||:||.|:.  ||::||..:|...|.|:|:|.||:.|  |.|.|
  Rat   332 EGCGRSFTTSNIRKVHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDK 396

  Fly   475 AFTKKHHLKTHLNYHTGCKPYVCPHPNCNQAFTQSSNMRTHAKKCQYRPLDGLTVTSSALPVPGK 539
            .||:...|..|...||..|||.|.|  |.:.:.|.|.:..|.:          |..:...|:..:
  Rat   397 RFTEYSSLYKHHVVHTHSKPYNCNH--CGKTYKQISTLAMHKR----------TAHNDTEPIEEE 449

  Fly   540 QQT--GPPPTLAMAMAQTFQMPPPPGV-----------LTPGSGPSQPPSQQTLLS 582
            |:.  .|||.....:.:..|:....||           ....||.||   |.||:|
  Rat   450 QEAFFEPPPGQGDDVLKGSQITYVTGVEGEDIVSTQVATVTQSGLSQ---QVTLIS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	2/19 (11%)
		COG5048	<316..502	CDD:227381	74/194 (38%)
		C2H2 Zn finger	327..347	CDD:275368	5/19 (26%)
		zf-C2H2	356..377	CDD:278523	10/21 (48%)
		C2H2 Zn finger	357..377	CDD:275368	9/20 (45%)
		zf-H2C2_2	369..394	CDD:290200	12/27 (44%)
		C2H2 Zn finger	385..405	CDD:275368	7/21 (33%)
		zf-H2C2_2	397..422	CDD:290200	11/26 (42%)
		C2H2 Zn finger	413..433	CDD:275368	7/21 (33%)
		zf-H2C2_2	426..449	CDD:290200	12/24 (50%)
		zf-C2H2	439..461	CDD:278523	9/23 (39%)
		C2H2 Zn finger	441..461	CDD:275368	8/21 (38%)
		zf-C2H2	467..489	CDD:278523	8/23 (35%)
		C2H2 Zn finger	469..489	CDD:275368	8/21 (38%)
		C2H2 Zn finger	497..515	CDD:275368	5/17 (29%)
Zfp143	NP_001012169.2	SFP1	<207..292	CDD:227516	23/85 (27%)
		C2H2 Zn finger	239..261	CDD:275368	5/21 (24%)
		COG5048	<251..424	CDD:227381	70/175 (40%)
		C2H2 Zn finger	269..291	CDD:275368	10/22 (45%)
		C2H2 Zn finger	299..321	CDD:275368	7/21 (33%)
		C2H2 Zn finger	329..351	CDD:275368	7/21 (33%)
		C2H2 Zn finger	359..381	CDD:275368	8/21 (38%)
		C2H2 Zn finger	389..411	CDD:275368	8/21 (38%)
		C2H2 Zn finger	419..438	CDD:275368	6/30 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010