DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and Zfp52

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001014180.1	Gene:	Zfp52 / 361487	RGDID:	1359149	Length:	755	Species:	Rattus norvegicus

Alignment Length:	420	Identity:	121/420 - (28%)
Similarity:	181/420 - (43%)	Gaps:	77/420 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 YQTHQHQQHLPNQQKRFFAPYVINGSVPPPPPLQQQQQPLIRTKSTACTRPDCPEC--LDYYQRL 197
            |:.|..::  |.:.:.......:|.::.....:..:::|.   :...|.: ...:|  |..|||:
  Rat   348 YRIHTVEK--PYRYEECDTSSTVNSTLKNHQKIHTREKPY---RYRECDK-SITKCSYLRTYQRV 406

  Fly   198 QTGGYKQTAPLISPAASSVSSSTGSIRPVRDLIMSATGGAASTNISLTTVTNLSLNSVQATAVGM 262
            .||                      :||.|         ....:.|.||.:||..:  |....|.
  Rat   407 HTG----------------------MRPYR---------CTECDKSFTTYSNLRQH--QKIHTGE 438

  Fly   263 MPKMTGG-----LITTAVGSNSGAIGGIGGYNATSAE------------------EISYKCRICE 304
            .|....|     |..::|..:.....|...|......                  |..|:|:.|:
  Rat   439 KPPNCKGSDKSFLRISSVRKHQKIHAGERRYGCKECSRSFTWFSNLRVHQRVHTGERPYRCKDCD 503

  Fly   305 KVFGCSETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKG 368
            |.|.....|:.|:|.|...: |:|.||...|..:.|.:.|..:|.|.|.:  :|.||.|:|....
  Rat   504 KSFTTGSNLRVHQKIHTGEKPYKCKDCDISFLWISNLRTHQKIHTGEKPY--KCQECKKSFTRCS 566

  Fly   369 YLSSHLKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTH 433
            ||..|.|||...|.|:|..|..||....:...|.:||||.||:||.||.|.|::...|:.|.:.|
  Rat   567 YLRDHQKIHTGEKLYKCKDCNVSFMWISSLRRHQKIHTGEKPYKCRECEKSFTQCSTLRDHQKIH 631

  Fly   434 SGEKPYQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCP 498
            :|||||:|..|..||...|::..|.::|:|.||:.|.:|..:|....:||||...|||.|||.|
  Rat   632 TGEKPYKCKDCDISFLWISSLRRHQKIHTGEKPYKCKVCGISFLWISNLKTHQKIHTGEKPYKC- 695

  Fly   499 HPNCNQAFTQSSNMRTHAK--------KCQ 520
             ..||::||:.|.:|.|.|        ||:
  Rat   696 -QECNKSFTRCSYLRVHQKTHTGEKPYKCK 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	75/186 (40%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-C2H2	356..377	CDD:278523	9/20 (45%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	12/24 (50%)
		C2H2 Zn finger	385..405	CDD:275368	5/19 (26%)
		zf-H2C2_2	397..422	CDD:290200	13/24 (54%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-H2C2_2	426..449	CDD:290200	11/22 (50%)
		zf-C2H2	439..461	CDD:278523	7/21 (33%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		zf-C2H2	467..489	CDD:278523	7/21 (33%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368	7/17 (41%)
Zfp52	NP_001014180.1	KRAB	44..84	CDD:396083
		C2H2 Zn finger	219..239	CDD:275368
		SFP1	<241..324	CDD:227516
		C2H2 Zn finger	247..295	CDD:275368
		C2H2 Zn finger	303..323	CDD:275368
		COG5048	329..702	CDD:227381	113/396 (29%)
		C2H2 Zn finger	331..351	CDD:275368	1/2 (50%)
		C2H2 Zn finger	359..379	CDD:275368	1/19 (5%)
		C2H2 Zn finger	388..407	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..435	CDD:275368	6/21 (29%)
		C2H2 Zn finger	443..463	CDD:275370	3/19 (16%)
		C2H2 Zn finger	471..491	CDD:275368	0/19 (0%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		C2H2 Zn finger	555..575	CDD:275368	9/19 (47%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	639..659	CDD:275368	6/19 (32%)
		C2H2 Zn finger	667..687	CDD:275368	7/19 (37%)
		C2H2 Zn finger	695..715	CDD:275368	9/21 (43%)
		zf-H2C2_2	707..730	CDD:404364	5/18 (28%)
		C2H2 Zn finger	723..743	CDD:275368	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010