DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15269 and ZNF530

DIOPT Version :9

Sequence 1:	NP_609739.2	Gene:	CG15269 / 34887	FlyBaseID:	FBgn0028878	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_065931.3	Gene:	ZNF530 / 348327	HGNCID:	29297	Length:	599	Species:	Homo sapiens

Alignment Length:	404	Identity:	124/404 - (30%)
Similarity:	186/404 - (46%)	Gaps:	50/404 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 AAAAGLSTPPTSP--YQTHQHQQHL--PNQQKRFFAPYVINGSVPPPPPLQ-QQQQPLIRTKSTA 181
            :|.:||.....:|  .:.|...:||  |..:|                ||: .:.:...|.||.
Human   178 SATSGLLQHQVTPTIERPHSRIRHLRVPTGRK----------------PLKYTESRKSFREKSV- 225

  Fly   182 CTRPDCPECLDYYQRLQTG--GYKQTAPLISPAASSVSSSTGSIRPVRDLIMSATGGAASTNISL 244
                     ...:||..:|  .||     .|....|.|.|:|.:|..:....:.|...:....|.
Human   226 ---------FIQHQRADSGERPYK-----CSECGKSFSQSSGFLRHRKAHGRTRTHECSECGKSF 276

  Fly   245 TTVTNLSLNSVQATAVGMMPKMTGGLITTAVGSNSGAIGGIGGYNATSAEEISYKCRICEKVFGC 309
            :..|:|:.:  |....|..|     ...:..|.:...:..:..:......|..|:|..|.|.|..
Human   277 SRKTHLTQH--QRVHTGERP-----YDCSECGKSFRQVSVLIQHQRVHTGERPYECSECGKSFSH 334

  Fly   310 SETLQAHEKTHKSPR-YECADCGKGFSQLRNYKYHLSVHRGTKEFAAECPECGKTFNDKGYLSSH 373
            |..|..|...|.|.| |||::|||.||...|...|..||.|.:.:  ||.||||.|:...||..|
Human   335 STNLYRHRSAHTSTRPYECSECGKSFSHSTNLFRHWRVHTGVRPY--ECSECGKAFSCNIYLIHH 397

  Fly   374 LKIHRNRKEYECPYCPKSFNQRVAFNMHVRIHTGVKPHKCNECGKRFSRKMLLKQHMRTHSGEKP 438
            .:.|...:.|.|..|.|||.|:.....|.|:|||.:|::|:||||.||:...|.:|.|.|:..||
Human   398 QRFHTGERPYVCSECGKSFGQKSVLIQHQRVHTGERPYECSECGKVFSQSSGLFRHRRAHTKTKP 462

  Fly   439 YQCSVCGKSFADRSNMTLHHRLHSGIKPFSCPLCPKAFTKKHHLKTHLNYHTGCKPYVCPHPNCN 503
            |:||.|.|||:.::::..|..:|:|.:|:.|.:|.|:|.:|.||..|...||..:||.|  ..|.
Human   463 YECSECEKSFSCKTDLIRHQTVHTGERPYECSVCGKSFIRKTHLIRHQTVHTNERPYEC--DECG 525

  Fly   504 QAFTQSSNMRTHAK 517
            ::::|||.:..|.:
Human   526 KSYSQSSALLQHRR 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15269	NP_609739.2	C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	<316..502	CDD:227381	78/186 (42%)
		C2H2 Zn finger	327..347	CDD:275368	8/19 (42%)
		zf-C2H2	356..377	CDD:278523	10/20 (50%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..422	CDD:290200	12/24 (50%)
		C2H2 Zn finger	413..433	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..449	CDD:290200	12/22 (55%)
		zf-C2H2	439..461	CDD:278523	8/21 (38%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-C2H2	467..489	CDD:278523	8/21 (38%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	5/17 (29%)
ZNF530	NP_065931.3	KRAB	14..>55	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..88
		C2H2 Zn finger	213..233	CDD:275368	5/29 (17%)
		C2H2 Zn finger	241..261	CDD:275368	6/19 (32%)
		COG5048	264..598	CDD:227381	99/287 (34%)
		zf-C2H2	267..289	CDD:278523	4/23 (17%)
		C2H2 Zn finger	269..289	CDD:275368	4/21 (19%)
		zf-H2C2_2	281..306	CDD:290200	5/31 (16%)
		C2H2 Zn finger	297..317	CDD:275368	1/19 (5%)
		zf-H2C2_2	310..334	CDD:290200	6/23 (26%)
		C2H2 Zn finger	325..345	CDD:275368	7/19 (37%)
		zf-C2H2	351..373	CDD:278523	10/21 (48%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)
		C2H2 Zn finger	381..401	CDD:275368	9/19 (47%)
		zf-H2C2_2	397..416	CDD:290200	6/18 (33%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	10/19 (53%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		zf-H2C2_2	477..502	CDD:290200	8/24 (33%)
		C2H2 Zn finger	493..513	CDD:275368	8/19 (42%)
		zf-H2C2_2	505..530	CDD:290200	9/26 (35%)
		C2H2 Zn finger	521..541	CDD:275368	6/21 (29%)
		zf-H2C2_2	533..558	CDD:290200	1/7 (14%)
		C2H2 Zn finger	549..569	CDD:275368
		zf-H2C2_2	561..586	CDD:290200
		C2H2 Zn finger	577..597	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910